2021
DOI: 10.3389/fcell.2021.656883
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Cross-Talk Between Inflammation and Fibroblast Growth Factor 10 During Organogenesis and Pathogenesis: Lessons Learnt From the Lung and Other Organs

Abstract: The adult human lung is constantly exposed to irritants like particulate matter, toxic chemical compounds, and biological agents (bacteria and viruses) present in the external environment. During breathing, these irritants travel through the bronchi and bronchioles to reach the deeper lung containing the alveoli, which constitute the minimal functional respiratory units. The local biological responses in the alveoli that follow introduction of irritants need to be tightly controlled in order to prevent a massi… Show more

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Cited by 14 publications
(17 citation statements)
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“…As seen in other conditions, FGF2 promotes a high mitogenic potential and is involved in many biological processes, including tumor growth and invasion [21][22][23][24][25]. It modulates the role of eosinophilic and mast cells and other immune cells, making it an extremely important factor in the progression of urothelial carcinomas, especially regarding the latter's role in them [23][24][25]. Its receptor (FGFR3) shows mutations and overexpression in a large proportion of urothelial carcinomas and even represents a target for therapy with tyrosine kinase inhibitors [26].…”
Section: Discussionmentioning
confidence: 99%
“…As seen in other conditions, FGF2 promotes a high mitogenic potential and is involved in many biological processes, including tumor growth and invasion [21][22][23][24][25]. It modulates the role of eosinophilic and mast cells and other immune cells, making it an extremely important factor in the progression of urothelial carcinomas, especially regarding the latter's role in them [23][24][25]. Its receptor (FGFR3) shows mutations and overexpression in a large proportion of urothelial carcinomas and even represents a target for therapy with tyrosine kinase inhibitors [26].…”
Section: Discussionmentioning
confidence: 99%
“…IL-33 specifically primes basophils and mast cells and affects AM maturation toward M2-type polarization [ 59 , 60 ]. IL33 is also a marker of repair promotion and is expressed in AT2 during lung development and maturation [ 61 ]. It is also a significant factor that regulates hypoxia-induced lung injury and can mediate hypoxia-inducible factors [ 62 ].…”
Section: Discussionmentioning
confidence: 99%
“…We speculated that the currently used method for the intratracheal instillation of PM might impair the intrinsic aerodynamics of PM. We also speculated that the levels of available FGF10 in the lung positively impact the outcome of PM-induced lung injury ( 28 ).…”
Section: Discussionmentioning
confidence: 99%