2015
DOI: 10.1016/j.bbrc.2015.02.121
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Cross talk between Leishmania donovani CpG DNA and Toll-like receptor 9: An immunoinformatics approach

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Cited by 18 publications
(20 citation statements)
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“…The importance of TLR signaling to protect against Leishmania infections is further established by studies that have as direct targets several TLRs using specific agonists and knockout mice [16]. It has already been described that TLR9 can be activated by non-methylated CpG DNA found in Leishmania [9], but not in mammalian cells, in which these sequences are normally methylated [10].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The importance of TLR signaling to protect against Leishmania infections is further established by studies that have as direct targets several TLRs using specific agonists and knockout mice [16]. It has already been described that TLR9 can be activated by non-methylated CpG DNA found in Leishmania [9], but not in mammalian cells, in which these sequences are normally methylated [10].…”
Section: Discussionmentioning
confidence: 99%
“…The TLRs play an important role during Leishmania infections. TLR9 recognizes unmethylated CpG DNA sequences, which are commonly found in bacteria and Leishmania [9], but not in mammalian cells where these sequences are normally methylated [10]. It has been shown that the activation of TLR9 promotes a host-protective response.…”
Section: Introductionmentioning
confidence: 99%
“…The early effect of Tv DNA on macrophages could trigger a strong response potentially able to change the outcome of the host–parasite interaction. Apart from the general adjuvant effect of CpG DNA, it has been shown that specific sequences present in each pathogen genome could promote the specificity of the host immune response (Gupta et al ., 2015). Thus, there is a need to better understand the mechanisms regulating the response to CpG DNA from parasites such as trichomonas.…”
Section: Discussionmentioning
confidence: 99%
“…The other reason lies on the recognition of TLR9. TLR9 not only recognizes virus DNA but also detects bacterial and protozoan genomes with unmethylated CpG motifs (Bowie 2007;Gupta et al 2015;Thompson and Iwasaki 2008;Thompson et al 2011). However, the known ligand-TLR9 interaction sites are studied from a few specific ligands (Ohto et al 2015;Tanji et al 2013).…”
Section: Discussionmentioning
confidence: 99%
“…TLR7 and TLR8 recognize viral ssRNA. TLR9 detects unmethylated CpG motifs that are found in certain dsDNA viral, bacterial and protozoan genomes (Bowie 2007;Gupta et al 2015;Thompson and Iwasaki 2008;Thompson et al 2011).…”
Section: Introductionmentioning
confidence: 99%