Cross-talk between the autocrine (mitogenic) pheromone loop of the ciliate euplotes raikovi and the intracellular cyclic AMP concentration

The protein pheromone Er-1 of the ciliate Euplotes raikovi stimulates human T-cell activity: Involvement of interleukin-2 system

“…Accordingly, a protein kinase with close structural identity to mammalian ERK/MAPK was recently reported to be activated by Er-1 in E. raikovi [38]. Er-1 was also shown to inhibit adenylate cyclase in E. raikovi [58], thus Er-1 coupling to pathways other than MAPK cannot be excluded in Jurkat cells.…”