Cross-tolerance between ethanol and morphine in the guinea-pig ileum longitudinal-muscle/myenteric-plexus preparation

Mayer, Joel M.; Khanna, J. M.; Kalant, H.; Spero, L.

doi:10.1016/0014-2999(80)90451-3

Cited by 33 publications

(5 citation statements)

References 10 publications

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“…; see Jorgensen & Hole, 1981). In particular, cross-tolerance between ethanol and morphine has been reported with respect to the induction of hypothermia in rats (Khanna, Le, Kalant, & LeBlanc, 1975) and inhibition of contractions in guinea pig preparation (Mayer, Khanna, Kalant, & Spero, 1980). In addition, a number of studies have suggested the involvement of opioid peptides (and of some hormones, e.g., ACTH) in the defensive response of the organism to stress (Amir, Brown, & Amit, 1980) and in its effects on passive avoidance behavior (Castellano & Puglisi-Allegra, 1983).…”

Section: Discussionmentioning

confidence: 99%

Naloxone-reversible effects of ethanol on passive avoidance behavior in mice

Castellano

Pavone

1983

Psychobiology

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Performance impairments were evident, in CD! mice tested in a passive avoidance apparatus, following posttrial intraperitoneal administration of ethanol (1.0 and 2.0 glkg) or morphine (0.5 and 1.0 mglkg), or following posttrial immobilization stress (30 and 60 min). Lower doses of ethanol (0.5 glkg) or morphine (0.25 mglkg), or a shorter immobilization time (15 min) were ineffective. Ethanol, at an ineffective dose (0.50 glkg) enhanced both the effects of morphine and those of immobilization stress. The effects observed were antagonized by a per se ineffective dose of naloxone (1.0 mglkg). The possibility that opiates may have a critical but modulatory effect on the actions of ethanol and/or immobilization is discussed.

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Section: Discussionmentioning

confidence: 99%

Naloxone-reversible effects of ethanol on passive avoidance behavior in mice

Castellano

Pavone

1983

Psychobiology

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“…Mayer et a1. 28 have recently shown that the ileal Ion@tudinal-muscle/myenteric-plexus (LMMP) preparation of guinea pigs treated for 2 weeks with ethanol was not only tolerant to the inhibitory effect of ethanol, but was also cross-tolerant to the inhibitory effect of morphine on electrically stimulated contractions. Since this field-stimulated preparation does not permit a distinction between pre-and post-synaptic events to be made, the tolerance and cross-tolerance demonstrated by Mayer et al" with this preparation may be due to neuronal changes without necessarily involving alterations in smooth muscle function.…”

Section: Antagonism By Nifedipine Of Norepinephrine and K+ Contractionsmentioning

confidence: 99%

Demonstration of Central Nervous System Tolerance to Ethanol in Mice: Consequent Effects on Smooth Muscle in Vitro

Dillon

Waters

Triggle

1983

Alcoholism Clin & Exp Res

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Mice were given ethanol (9 g/kg) or saline (57 ml/kg) daily in three divided doses for periods of 1 and 4 days to study the effects of such ethanol (ETOH) exposure on central nervous system (CNS) and peripheral smooth muscle (vasa deferentia) function. After 1 day, ETOH-treated mice were functionally tolerant to the hypothermic (3 g/kg, intraperitoneal), but not to the hypnotic (3.25 g/kg, intraperitoneal) effect of ETOH. Functional tolerance to both CNS effects of ETOH was demonstrated in mice after the 4-day ETOH exposure. Norepinephrine (NE) and high K+-depolarizing solutions each elicited dose-dependent contractions in the mouse vasa deferens preparation in vitro that consisted of a phasic and tonic component. The tonic components of the NE and K+ responses were more dependent upon extracellular Ca2+ (Ca2+ext) than the phasic components. Addition of ETOH (120 to 480 mM) or the Ca2+ channel-antagonist nifedipine (1 X 10(-9) to 3 X 10(-7) M) to the preparation selectively inhibited the tonic component of the NE and K+ responses, suggesting that both agents acted to inhibit the responses by interfering with the translocation of Ca2+ext. Vasa deferentia isolated from ETOH-treated mice did not exhibit altered reactivity to NE in the phasic or tonic component of the response. The isolated smooth muscle from mice centrally tolerant to ETOH did not appear to be tolerant to inhibitory effect of ETOH or cross-tolerant to the inhibitory effect of nifedipine on stimulant-induced contractions.

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“…Moreover, morphine-induced coma is reversed by low doses of naloxone, while ethanol-induced coma is not . However, with respect to inhibition of contraction in the guinea-pig ileum, crosstolerance is seen between morphine and ethanol but not between them and barbital (Mayer et al 1980). It therefore appears that the three drugs have three different spectra of actions on different parts of the nervous system, i.e.…”

Section: Discussionmentioning

confidence: 76%

“…More recently, cross-tolerance between ethanol and morphine has been demonstrated with respect to their hypothermic effect in rats (Khanna et al 1979) and their inhibitory effect on the isolated guinea-pig ileum preparation (Mayer et al 1980). All these reports raise the possibility that ethanol and morphine may share some common mechanisms related to their acute or chronic actions.…”

mentioning

confidence: 97%

Differential pharmacological responses to ethanol, pentobarbital and morphine in rats selectively bred for ethanol sensitivity

et al. 1983

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The hypothermic and analgesic effects of ethanol, pentobarbital and morphine were examined in two lines of rats that had been selectively bred for their differential sensitivity to ethanol. Males and females of the least-affected (LA) line were observed to be less sensitive than their most-affected (MA) counterparts to hypothermia and analgesia induced by ethanol and morphine. By contrast, no differences were observed with respect to pentobarbital-induced hypothermia. At the dose used, pentobarbital had no significant analgesic effect in either animal line.

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Cross-tolerance between ethanol and morphine in the guinea-pig ileum longitudinal-muscle/myenteric-plexus preparation

Cited by 33 publications

References 10 publications

Naloxone-reversible effects of ethanol on passive avoidance behavior in mice

Naloxone-reversible effects of ethanol on passive avoidance behavior in mice

Demonstration of Central Nervous System Tolerance to Ethanol in Mice: Consequent Effects on Smooth Muscle in Vitro

Differential pharmacological responses to ethanol, pentobarbital and morphine in rats selectively bred for ethanol sensitivity

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