Crossed Corticospinal Facilitation Between Arm and Trunk Muscles Correlates With Trunk Control After Spinal Cord Injury

Chiou, See-Ying; Strutton, Paul H.

doi:10.3389/fnhum.2020.583579

Cited by 12 publications

(22 citation statements)

References 57 publications

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“…Our findings therefore inform a more comprehensive understanding of the basic principles of human motor control related to the arm-trunk neural interaction. Taken together, these results may also suggest that functional movement synergy oriented training is crucial in rehabilitation to strengthen arm-trunk interactions as a way for improving functional performance after neurological impairments such as spinal cord injury Chiou and Strutton, 2020).…”

Section: Significance Of Corticospinal Remote Facilitationmentioning

confidence: 77%

“…Our work has several limitations that should be noted. First, some previous studies investigating interactions between trunk and upper-limb muscles have examined contralateral side trunk muscles to the contracted arm to elicit MEP responses (Chiou et al, 2018;Chiou and Strutton, 2020;Davey et al, 2002), while we chose to investigate the ipsilateral side in the current study. Davey et al, (2002) previously reported that ES muscle activity in the contralateral side to contracted arm was increased when arm muscle contractions during shoulder abduction were increased, while that of ipsilateral side was not affected considerably.…”

Section: Limitationsmentioning

confidence: 99%

“…Since trunk muscles are activated in a highly coordinated manner during voluntary arm movements (Aruin and Latash, 1995;, characteristics of arm-trunk neural interactions may be different from those observed in interlimb remote effect facilitation (Tazoe and Komiyama, 2014). Moreover, since previous studies investigating arm-trunk neural interaction used only one contraction intensity (i.e., either 20 or 30% MVC level) (Chiou et al, 2018;Chiou and Strutton, 2020;Sasaki et al, 2018bSasaki et al, , 2020b, it was not clear how neural interactions between arm and trunk muscles would be modulated during different contraction intensities. Therefore, investigating arm-trunk remote effect facilitation during different exertion levels and tasks may provide new insights about underlying neural interaction mechanisms in the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

“…Although corticospinal remote facilitation may be responsible for controlling arm-trunk coordinated movements (Chiou and Strutton, 2020), its mechanisms are yet to be fully understood.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it was recently reported that trunk muscle corticospinal excitability could be facilitated after short-term upper-limb training . Arm-trunk corticospinal remote facilitation may also be attributed to quicker anticipatory postural adjustments of the trunk during rapid shoulder flexion in patients with spinal cord injury (Chiou and Strutton, 2020). Therefore, a thorough understanding of the characteristic of armtrunk corticospinal interactions may also be helpful to develop new rehabilitation interventions for targeting improvements in arm-trunk interactions.…”

Section: Introductionmentioning

confidence: 99%

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Task- and Intensity-Dependent Modulation of Arm-Trunk Neural Interactions in the Corticospinal Pathway in Humans

Sasaki

Kaneko

Masugi

et al. 2021

eNeuro

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Most human movements require coordinated activation of multiple muscles. Although many studies reported associations between arm, leg, and trunk muscles during functional tasks, their neural interaction mechanisms still remain unclear. Therefore, the aim of our study was to investigate arm-trunk or arm-leg neural interactions in the corticospinal tract during different arm muscle contractions. Specifically, we examined corticospinal excitability of the erector spinae (ES; trunk extensor), rectus abdominis (RA; trunk flexor), and tibialis anterior (TA; leg) muscles while participants exerted: (1) wrist flexion; and (2) wrist extension isometric contraction at various contraction intensity levels ranging from rest to 50% of maximal voluntary contraction (MVC) effort. Corticospinal excitability was assessed using motor evoked potentials (MEPs) elicited through motor cortex transcranial magnetic stimulation. Results showed that ES MEPs were facilitated even at low contractions (>5% MVC) during wrist flexion and extension, while stronger contractions (>25% MVC) were required to facilitate RA MEPs. The extent of facilitation of ES MEPs depended on contraction intensity of wrist extension, but not flexion.Moreover, TA MEPs were facilitated at low contractions (>5% MVC) during wrist flexion and extension, but contraction intensity dependence was only shown during stronger wrist extension contractions (>25% MVC). In conclusion, trunk extensor corticospinal excitability seems to depend on the task and the intensity of arm contraction, while this is not true for trunk flexor and leg muscles. Our study therefore demonstrated task-and intensity-dependent neural interactions of arm-trunk connections, which may underlie anatomical and/or functional substrates of these muscle pairs. 4 Significance StatementAlthough it is known that most human movements require coordinated activation of multiple muscles, understanding of how they are controlled in the central nervous system still lacks. Our study investigated the characteristics of neural interactions of arm-trunk and arm-leg muscles in the corticospinal tract of human participants using motor evoked potentials elicited by transcranial magnetic stimulation. We showed that arm muscle contractions can facilitate corticospinal excitability of the trunk and leg muscles. Specifically, arm-trunk neural interactions depended on the task and intensity of arm movements. Our findings therefore suggest that corticospinal neurons have complex output patterns to distinct muscles in different body segments, which may depend on the anatomical and/or functional relationship of these muscle pairs.

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Section: Significance Of Corticospinal Remote Facilitationmentioning

confidence: 77%

Section: Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Although corticospinal remote facilitation may be responsible for controlling arm-trunk coordinated movements (Chiou and Strutton, 2020), its mechanisms are yet to be fully understood.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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