Crossfostering in mice selectively bred for high and low levels of open‐field thigmotaxis

Leppänen, Pia K.; Ewalds-Kvist, S. Béatrice M.

doi:10.1111/j.1467-9450.2005.00431.x

Cited by 11 publications

(3 citation statements)

References 70 publications

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“…That is, as the exposure to the OF increased, the field became less frightening to the mouse, thereby decreasing Belzung, 1995). In a previous crossfostering study (Leppänen & Ewalds-Kvist, 2005), the strains did not differ in defecation in a 2-min OF test.…”

Section: Discussionmentioning

confidence: 72%

Mice Selectively Bred for Open-Field Thigmotaxis: Life Span and Stability of the Selection Trait

Leppänen¹,

Ewalds-Kvist²,

Selander³

2005

The Journal of General Psychology

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In 2 experiments, the authors examined 69 mice selectively bred for high or low levels of open-field (OF) thigmotactic behavior (high open-field thigmotaxis [HOFT] and low open-field thigmotaxis [LOFT], respectively). They found that the strains differed in defecation during the 60-min exposure to the OF. Furthermore, the strains differed with regard to their life spans: The more thigmotactic HOFT mice lived longer than the LOFT mice. The strains were not differentiated by food intake or excretion. The strain difference in thigmotaxis was not age dependent, and it persisted in the home-cage condition as well. Neither the location (center or wall) of the starting point nor the shape (circular or square) of the OF arena affected the difference in wall-seeking behavior between the two strains. The authors concluded that the difference in thigmotaxis (or emotionality) between the HOFT and LOFT mice is a stable and robust feature of these animals.

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Section: Discussionmentioning

confidence: 72%

Mice Selectively Bred for Open-Field Thigmotaxis: Life Span and Stability of the Selection Trait

Leppänen¹,

Ewalds-Kvist²,

Selander³

2005

The Journal of General Psychology

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“…They may be measured manually, by video recording or by automated sampling making use of photo beams. The size of open field arenas used to study behavior of mice may reach 90 cm Â 90 cm, although most arenas range from 30 cm Â 30 cm to 60 cm Â 60 cm (Gill and Boyle, 2005;Henderson et al, 2004;Kafkafi et al, 2005;Leppanen and Ewalds-Kvist, 2005;Nagy and McKay, 1972;Singer et al, 2005;Trullas and Skolnick, 1993). In a smaller open field arena the measurement of locomotor activity is more reliable, because emotional factors influencing locomotor activity are supposed to be reduced.…”

Section: The Test System Motility Boxmentioning

confidence: 98%

Maternal and Genetic Effects on Anxiety-Related Behavior of C3H/HeN, DBA/2J and NMRI Mice in a Motility-Box Following Blastocyst Transfer

et al. 2006

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Reciprocal embryo transfers were conducted to examine genetic and maternal effects on the behavior of inbred C3H/HeN and DBA/2J mice, and outbred NMRI mice using a motility-box. The behavioral variables measured were (i) horizontal locomotor activity assessed as the path and time spent during traveling; (ii) vertical activity assessed as the time spent with and numbers of rearings/leanings; (iii) and the time spent in the more anxiogenic central field. The transfer procedure per se resulted in a minor increase in vertical activity of inbred C3H/HeN mice, but had no effect in inbred DBA/2J mice. In contrast, outbred NMRI mice displayed a lower central field activity following embryo transfer indicating a higher anxiety level. Moreover, genetic differences between the mouse strains studied remained stable following embryo transfer for locomotor and vertical activity, but not central field activity depending on the recipient mother strain. Maternal effects were found for (i) vertical activity in the two inbred mouse strains, (ii) all behavioral variables studied in outbred NMRI mice, and (iii) an interaction with gender for the time spent in the anxiogenic central field. An additional fostering procedure revealed that the vertical activity of NMRI mice was modified towards the behavior of the recipient C3H/HeN strain by uterine factors, whereas the postnatal maternal effect of C3H/HeN mothers was the opposite. In summary, the effects of the embryo transfer procedure per se, stability of genetic characteristics following embryo transfer and maternal effects were related to the mouse strains used as donators and recipients, and the behavioral variables studied.

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“…The open field test screening efficacy, anxiety-related, and locomotor effects of neurobiological manipulations by using clear cage and record the change that happened on mice in the cage like urination, cleaning coat, movement of animal. [12, 13,14]…”

Section: Open Field Areamentioning

confidence: 99%

The Effect of Piracetam against Acetyl Choline (Ach) In Behavioral Changes with Some Biochemical Parameters in Adult Mice

Al-Shimmary,

Naqi,

Al Bayati

et al. 2017

Kufa Jou. Vete. Med. Sci.

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The effects of Piracetam against Acetyl Choline (Ach) in adult mice. The Medium Lethal Dose LD50 of Piracetam was 455.5mg/kg B.W. orally and Ach 7.25 mg/kg B.W i.p, then an animal’s are divided to 4 groups First group serves as control group given normal saline, a second 400 mg /kg B.W. o.p. of Piracetam and third group 5 mg/kg B.W. i.p. Ach. Forth group 400 mg /kg B.W. o.p. of Piracetam and 5 mg/kg B.W. i.p. Ach. The behavioral changes, the Run time, swimming, Time on glass, and biochemical parameters in Ach and Piracetam pretreatment significantly (P<0.05) decreased of Run time and swimming, then increased Time on glass when compared with the control. The open field test was significantly (P<0.05) increased the termer, depression when compared with the control. The liver function tests was significantly (P<0.05) increased the in level of GPT and GOT enzymes in the plasma at forth group.

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Crossfostering in mice selectively bred for high and low levels of open‐field thigmotaxis

Cited by 11 publications

References 70 publications

Mice Selectively Bred for Open-Field Thigmotaxis: Life Span and Stability of the Selection Trait

Mice Selectively Bred for Open-Field Thigmotaxis: Life Span and Stability of the Selection Trait

Maternal and Genetic Effects on Anxiety-Related Behavior of C3H/HeN, DBA/2J and NMRI Mice in a Motility-Box Following Blastocyst Transfer

The Effect of Piracetam against Acetyl Choline (Ach) In Behavioral Changes with Some Biochemical Parameters in Adult Mice

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