Crosslinked hydrogels based on biological macromolecules with potential use in skin tissue engineering

Vulpe, Raluca; Popa, Marcel; Picton, Luc; Bǎlan, Vera; Dulong, Virginie; Butnaru, Maria; Vereştiuc, Liliana

doi:10.1016/j.ijbiomac.2015.12.019

Cited by 38 publications

(20 citation statements)

References 36 publications

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“…Similar effect was observed from the comparison of NaCMC hydrogel pairs numbered as (1-4), (5)(6)(7)(8), and (9-12). Besides, increasing the amount of polymer in the hydrogels numbered as (1-5-9) and (4-8-12) resulted in a decrease in pore sizes [27]. Average pore density values were compassable with pore sizes.…”

Section: Sem/edx Analysis Sem Analysis Was Performed To Determine Momentioning

confidence: 95%

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Preparation and Characterization of Nanoporous Sodium Carboxymethyl Cellulose Hydrogel Beads

Akalın

Pulat

2018

Journal of Nanomaterials

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A series of nanoporous sodium carboxymethyl cellulose (NaCMC) hydrogel beads were prepared using FeCl3 ionic crosslinker by changing polymer and crosslinker percentages (%). Characteristics of the hydrogels were investigated by gel content, swelling test, degradation test, Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR), Scanning Electron Microscope/Energy Dispersive X-ray Analysis (SEM/EDX), and Atomic Force Microscopy (AFM). Swelling experiments were studied by changing time, temperature, and pH. The swelling percentage (S%) regularly decreased with increasing the amounts of polymer and crosslinker, in contrast with gel content results. NaCMC hydrogels were found to be sensitive to pH variations. The degradation test showed that hydrogels had good stability and their degradation period varied from 30 to 36 days. According to SEM analysis, NaCMC hydrogels had mostly nanoporous structure. The average granule and pore sizes of the least swollen NaCMC-12 hydrogel were found to be 13.1±0.3 nm and 82.1±3.2 nm. The elemental compositions of hydrogels were determined with EDX. The minimum average surface roughness (Ra) and root mean square roughness (Rms) parameters were found to be 15.7±1.9 nm and 20.3±2.2 nm for NaCMC-12 hydrogels by AFM. Due to their good morphologies, stabilities, and swelling behaviors, NaCMC hydrogels can be suitable for biomaterial applications.

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Section: Sem/edx Analysis Sem Analysis Was Performed To Determine Momentioning

confidence: 95%

“…Then, they were placed into the same medium and the weighing was continued at regular intervals until hydrogel completely degraded. The degradation was determined in terms of weight loss (%) from [26,27].…”

Section: Degradation Test Degradation Tests Of Hydrogel Beadsmentioning

confidence: 99%

Preparation and Characterization of Nanoporous Sodium Carboxymethyl Cellulose Hydrogel Beads

Akalın

Pulat

2018

Journal of Nanomaterials

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“…Specifically, an HA and Fe + complex assembled hydrogel was able to inhibit microbial infections [ 83 ]. HA and sodium alginate hydrogel were favorable to keratinocytes anchoring [ 84 ], while methacrylhydrazide-HA gel and HA-collagen-sericin gel were tested with human fibroblasts showing good cell viability [ 85 , 86 ]. A polycaprolactone-HA-epidermal growth factor nanofibrous scaffold with high bioactivity was proposed for wound healing applications [ 87 ].…”

Section: Medical Applications Of Ha and Its Derivativesmentioning

confidence: 99%

Hyaluronic Acid: Redefining Its Role

Abatangelo

Vindigni

Avruscio

et al. 2020

Cells

319

166

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The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has promoted new research impetus for biologists and, the clinical interest in several fields of medicine, such as ophthalmology, articular pathologies, cutaneous repair, skin remodeling, vascular prosthesis, adipose tissue engineering, nerve reconstruction and cancer therapy. In addition, the great potential of HA in medicine has stimulated the interest of pharmaceutical companies which, by means of new technologies can produce HA and several new derivatives in order to increase both the residence time in a variety of human tissues and the anti-inflammatory properties. Minor chemical modifications of the molecule, such as the esterification with benzyl alcohol (Hyaff-11® biomaterials), have made possible the production of water-insoluble polymers that have been manufactured in various forms: membranes, gauzes, nonwoven meshes, gels, tubes. All these biomaterials are used as wound-covering, anti-adhesive devices and as scaffolds for tissue engineering, such as epidermis, dermis, micro-vascularized skin, cartilage and bone. In this review, the essential biological functions of HA and the applications of its derivatives for pharmaceutical and tissue regeneration purposes are reviewed.

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“…The last one is attributed to the cleavage of ester bonds in hybrid, which required higher degradation temperatures (350-450°C) (14). Also, the copolymers have lower onset temperature values than their precursors (15). Because of the amphiphilicity of the prepared hybrid, the fraction of P(3HB) was kept up to 13±2 % to allow the derivative to be fully soluble in water.…”

Section: Effect Of the Covalent Bonding Of Ha And Poly(3-hydroxybutyrmentioning

confidence: 99%

Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications

Huerta-Ángeles

Knotková

Knotek

et al. 2018

J Mater Sci: Mater Med

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In this work, a hybrid copolymer consisting of poly(3-hydroxybutyrate) grafted to hyaluronic acid (HA) was synthesised and characterised. Once formed, the P(3HB)-g-HA copolymer was soluble in water allowing a green electrospinning process. The diameters of nanofibres can be tailored by simply varying the M of polymer. The optimization of the process allowed to produce fibres of average diameter in the range of 100-150 nm and low polydispersity. The hydrophobic modification has not only increased the fibre diameter, but also the obtained layers were homogenous. At the nanoscale, the hybrid copolymer exhibited an unusual hairy topography. Moreover, the hardness and tensile properties of the hybrid were found to be superior compared to fibres made of unmodified HA. Particularly, this reinforcement was achieved at the longitudinal direction. Additionally, this work reports the use in the composition of a water-soluble copolymer containing photo cross-linkable moieties to produce insoluble materials post-electrospinning. The derivatives as well as their nanofibrous mats retain the biocompatibility of the natural polymers used for the fabrication.

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Crosslinked hydrogels based on biological macromolecules with potential use in skin tissue engineering

Cited by 38 publications

References 36 publications

Preparation and Characterization of Nanoporous Sodium Carboxymethyl Cellulose Hydrogel Beads

Preparation and Characterization of Nanoporous Sodium Carboxymethyl Cellulose Hydrogel Beads

Hyaluronic Acid: Redefining Its Role

Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications

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