Crosslinked poly-γ-glutamic acid based nanosystem for drug delivery

Csikós, Zsuzsanna; Fazekas, Erika; Rózsa, Dávid; Borbély, János; Kerekes, Krisztina

doi:10.1016/j.jddst.2018.10.026

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Moreover, γ-PGA serves as a good adjuvant by inducing a higher vaccine antigens’ immunogenicity ( Nguyen et al, 2019 ). Γ-PGA is known to protect probiotics and Caco-2 cells against oxidative damage as well ( Csikós et al, 2018 ).…”

Section: Applications Of γ-Pgamentioning

confidence: 99%

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

Elbanna,

Alsulami,

Neyaz

et al. 2024

Front. Microbiol.

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Microbial biopolymers have emerged as promising solutions for environmental pollution-related human health issues. Poly-γ-glutamic acid (γ-PGA), a natural anionic polymeric compound, is composed of highly viscous homo-polyamide of D and L-glutamic acid units. The extracellular water solubility of PGA biopolymer facilitates its complete biodegradation and makes it safe for humans. The unique properties have enabled its applications in healthcare, pharmaceuticals, water treatment, foods, and other domains. It is applied as a thickener, taste-masking agent, stabilizer, texture modifier, moisturizer, bitterness-reducing agent, probiotics cryoprotectant, and protein crystallization agent in food industries. γ-PGA is employed as a biological adhesive, drug carrier, and non-viral vector for safe gene delivery in tissue engineering, pharmaceuticals, and medicine. It is also used as a moisturizer to improve the quality of hair care and skincare cosmetic products. In agriculture, it serves as an ideal stabilizer, environment-friendly fertilizer synergist, plant-growth promoter, metal biosorbent in soil washing, and animal feed additive to reduce body fat and enhance egg-shell strength.

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Section: Applications Of γ-Pgamentioning

confidence: 99%

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

Elbanna,

Alsulami,

Neyaz

et al. 2024

Front. Microbiol.

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“…This approach is successful as long as the selected targets for a specific cancer cell type can be recognized with confidence and are not expressed in considerable amounts elsewhere in the body [ 122 , 123 ]. An investigation elaborated on the synthesis of the active targeted water-soluble delivery of DOX [ 138 ]. This research involved two biodegradable and biocompatible biopolymers, poly-γ-glutamic acid (PGA) and chitosan.…”

Section: Dox–chitosan-mediated Nps For Drug Deliveriesmentioning

confidence: 99%

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Imran,

Tang,

Wang

et al. 2023

Molecules

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Chitosan nanoparticles (NPs) serve as useful multidrug delivery carriers in cancer chemotherapy. Chitosan has considerable potential in drug delivery systems (DDSs) for targeting tumor cells. Doxorubicin (DOX) has limited application due to its resistance and lack of specificity. Chitosan NPs have been used for DOX delivery because of their biocompatibility, biodegradability, drug encapsulation efficiency, and target specificity. In this review, various types of chitosan derivatives are discussed in DDSs to enhance the effectiveness of cancer treatments. Modified chitosan–DOX NP drug deliveries with other compounds also increase the penetration and efficiency of DOX against tumor cells. We also highlight the endogenous stimuli (pH, redox, enzyme) and exogenous stimuli (light, magnetic, ultrasound), and their positive effect on DOX drug delivery via chitosan NPs. Our study sheds light on the importance of chitosan NPs for DOX drug delivery in cancer treatment and may inspire the development of more effective approaches for cancer chemotherapy.

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“…This proposed method has potential advantages over other ADCs because the NPDC can be precisely prefabricated [ 67 , 68 ], and in the final step, it can be conjugated to the mAb, resulting in the appropriate ACNP ( Figure 3 ). It is suspected that these constructions have the benefits of highly targeting cancer cells due to their antibody content, as well as a high efficacy due to the high payload carried by the conjugated nanoparticles.…”

Section: Randd Of Adc Technologiesmentioning

confidence: 99%

Business Risk Mitigation in the Development Process of New Monoclonal Antibody Drug Conjugates for Cancer Treatment

Kiss

Borbély

2023

Pharmaceutics

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Recent developments aim to extend the cytotoxic effect and therapeutic window of mAbs by constructing antibody–drug conjugates (ADCs), in which the targeting moiety is the mAb that is linked to a highly toxic drug. According to a report from mid of last year, the global ADCs market accounted for USD 1387 million in 2016 and was worth USD 7.82 billion in 2022. It is estimated to increase in value to USD 13.15 billion by 2030. One of the critical points is the linkage of any substituent to the functional group of the mAb. Increasing the efficacy against cancer cells’ highly cytotoxic molecules (warheads) are connected biologically. The connections are completed by different types of linkers, or there are efforts to add biopolymer-based nanoparticles, including chemotherapeutic agents. Recently, a combination of ADC technology and nanomedicine opened a new pathway. To fulfill the scientific knowledge for this complex development, our aim is to write an overview article that provides a basic introduction to ADC which describes the current and future opportunities in therapeutic areas and markets. Through this approach, we show which development directions are relevant both in terms of therapeutic area and market potential. Opportunities to reduce business risks are presented as new development principles.

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Crosslinked poly-γ-glutamic acid based nanosystem for drug delivery

Cited by 7 publications

References 25 publications

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Business Risk Mitigation in the Development Process of New Monoclonal Antibody Drug Conjugates for Cancer Treatment

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