Crosslinking diversity on network morphology, template binding, and template transport of molecularly imprinted polymers prepared via living radical polymerization

Abstract

The objective of this work is to study the effects of altering the chain building blocks and the reaction on template binding and transport parameters of imprinted polymer gels. The characterization of imprinted poly(diethylaminoethylmethacrylate-cohydroxyethylmethacrylate-co-polyethyleneglycol(n)dimethacrylate) polymer gels prepared via free (FRP) or living (LRP) radical polymerization with varying crosslinking monomer lengths (number of ethylene glycol repeat units of 1, 4.5, 9) and concentrations (1, 5, 10, 50%) is presented. All imprinted networks prepared via LRP exhibited significantly higher template binding affinities and capacities as well as significantly lower template diffusion coefficients compared to those prepared via FRP. Synthesizing imprinted polymers via LRP results in much smaller and relatively constant dispersities of polymer chains compared to imprinted polymers prepared via FRP. Therefore, LRP has a profound structural effect on the imprinted polymer network leading to increased homogeneity in the mesh structure which enhances the molecular imprinting effect.

One Week Sustained In Vivo Therapeutic Release and Safety of Novel Extended‐Wear Silicone Hydrogel Contact Lenses

“…However, there is a synergistic relationship between mesh size and imprinting efficiency as previously studied by our group. [ 36,37 ]…”

“…However, there is a synergistic relationship between mesh size and imprinting efficiency as previously studied by our group. [36,37] As mesh size and the flexibility of the network structure decrease, macromolecular memory increases. To test this hypothesis, we produced lenses with a higher elastic modulus and decreased mesh size by keeping the formulation the same but utilizing macromers of the same chemistry that were ≈13 times lower in molecular weight/smaller in linear size.…”

Desorption of 3,3′-diindolylmethane from imprinted particles: An impact of cross-linker structure on binding capacity and selectivity

“…The highest imprinting effect was noted for the system consisting of up to 50% of cross-linker. The impact of cross-linking structure on the morphology and the template transport into the imprinted gels was investigated by Salian and Byrne [14]. They analyzed the systems that were produced …”