2024
DOI: 10.1002/alz.13864
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Crosstalk between bone and brain in Alzheimer's disease: Mechanisms, applications, and perspectives

Zhuo‐Ting Liu,
Ming‐Han Liu,
Yan Xiong
et al.

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease that involves multiple systems in the body. Numerous recent studies have revealed bidirectional crosstalk between the brain and bone, but the interaction between bone and brain in AD remains unclear. In this review, we summarize human studies of the association between bone and brain and provide an overview of their interactions and the underlying mechanisms in AD. We review the effects of AD on bone from the aspects of AD pathogenic proteins, AD risk gen… Show more

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