“…Recent studies have revealed that translation strongly affects mRNA stability in cis in a codon-dependent manner in vertebrates (Bazzini et al, 2016;Mishima & Tomari, 2016; as well as in other species (Boël et al, 2016;Burow et al, 2018;de Freitas Nascimento et al, 2018;Harigaya & Parker, 2016;Jeacock, Faria, & Horn, 2018;Presnyak et al, 2015;Radhakrishnan et al, 2016), a process referred as codon optimality (Presnyak et al, 2015). Codon optimality is the most pervasive mechanism underlying mRNA stability in yeast (Cheng, Maier, Avsec, Rus, & Gagneur, 2017) and vertebrates (Medina-Muñoz et al, 2021). Specifically, to determine the regulatory strength of codon optimality in vertebrates, we have recently developed a machine learning model that predicts mRNA stability based on codon composition (Medina-Muñoz et al, 2021).…”