Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model

Schwarz, Agatha; Philippsen, Rebecca; Piticchio, Serena G.; Hartmann, Jan N.; Häsler, Robert; Rose-John, Stefan; Schwarz, Thomas

doi:10.3389/fimmu.2023.1038689

Cited by 4 publications

(2 citation statements)

References 69 publications

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“…SCFAs have been extensively studied for their role in modulating Treg and Th17 differentiation [128][129][130][131][132]. Through various pathways including G-protein-coupled receptor signaling and histone deacetylase (HDAC) modulation, SCFAs can induce Treg differentiation while inhibiting Th17 differentiation [133][134][135]. Furthermore, gut microbiota impacts Treg and Th17 differentiation by modulating bile acid metabolism, a subject extensively reviewed by Su et al in the latest publication in Frontiers in Immunology 2023 [125].…”

Section: Multiple Roles Of Gut Microbiota In Regulating Il-17-produci...mentioning

confidence: 99%

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

Cui,

Wang,

et al. 2024

Cell Commun Signal

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The changes in T regulatory cell (Treg) and T helper cell (Th) 17 ratios holds paramount importance in ensuring internal homeostasis and disease progression. Recently, novel subsets of Treg and Th17, namely IL-17-producing Treg and IL-10-producing Th17 have been identified. IL-17-producing Treg and IL-10-producing Th17 are widely considered as the intermediates during Treg/Th17 transformation. These “bi-functional” cells exhibit plasticity and have been demonstrated with important roles in multiple physiological functions and disease processes. Yin and Yang represent opposing aspects of phenomena according to the ancient Chinese philosophy “Yin-Yang” theory. Furthermore, Yin can transform into Yang, and vice versa, under specific conditions. This theory has been widely used to describe the contrasting functions of immune cells and molecules. Therefore, immune-activating populations (Th17, M1 macrophage, etc.) and immune overreaction (inflammation, autoimmunity) can be considered Yang, while immunosuppressive populations (Treg, M2 macrophage, etc.) and immunosuppression (tumor, immunodeficiency) can be considered Yin. However, another important connotation of “Yin-Yang” theory, the conversion between Yin and Yang, has been rarely documented in immune studies. The discovery of IL-17-producing Treg and IL-10-producing Th17 enriches the meaning of “Yin-Yang” theory and further promotes the relationship between ancient “Yin-Yang” theory and modern immunology. Besides, illustrating the functions of IL-17-producing Treg and IL-10-producing Th17 and mechanisms governing their differentiation provides valuable insights into the mechanisms underlying the dynamically changing statement of immune statement in health and diseases.

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Section: Multiple Roles Of Gut Microbiota In Regulating Il-17-produci...mentioning

confidence: 99%

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

Cui,

Wang,

et al. 2024

Cell Commun Signal

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“…Interactions between SCFAs and their receptor HCA2 are noteworthy, especially given that HCA2 expression is downregulated in lesions of psoriatic skin. In exploratory studies utilizing mice with HCA2 gene knockout (HCA2-KO), the severity of the inflammatory response to IMQ was found to be elevated, implicating a probable dysfunction in Treg cells ( 58 ). SCFAs appear to facilitate both the genesis and functional activity of Tregs.…”

Section: Regulation Of Lipid Metabolism On T Cell In Psoriasismentioning

confidence: 99%

Metabolic influences on T cell in psoriasis: a literature review

Su,

Zhao,

Zhang

et al. 2023

Front. Immunol.

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Psoriasis is a systemic inflammatory disease that frequently coexists with various other conditions, such as essential hypertension, diabetes, metabolic syndrome, and inflammatory bowel disease. The association between these diseases may be attributed to shared inflammatory pathways and abnormal immunomodulatory mechanisms. Furthermore, metabolites also play a regulatory role in the function of different immune cells involved in psoriasis pathogenesis, particularly T lymphocytes. In this review, we have summarized the current research progress on T cell metabolism in psoriasis, encompassing the regulation of metabolites in glucose metabolism, lipid metabolism, amino acid metabolism, and other pathways within T cells affected by psoriasis. We will also explore the interaction and mechanism between psoriatic metabolites and immune cells. Moreover, we further discussed the research progress of metabolomics in psoriasis to gain a deeper understanding of its pathogenesis and identify potential new therapeutic targets through identification of metabolic biomarkers associated with this condition.

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Advances in the mechanism of action of short-chain fatty acids in psoriasis

Zhang,

Zhao,

et al. 2024

International Immunopharmacology

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Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model

Cited by 4 publications

References 69 publications

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

Metabolic influences on T cell in psoriasis: a literature review

Advances in the mechanism of action of short-chain fatty acids in psoriasis

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