Crosstalk between microwave ablation and ferroptosis: The next hot topic?

Lei, Yu; Cheng, Min; Liu, Jie; Ye, Xin; Wei, Zhigang; Xu, Jing; Xie, Qi; Liang, Jing

doi:10.3389/fonc.2023.1099731

Cited by 6 publications

(5 citation statements)

References 102 publications

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“…This mechanism could play a role in the tumor-killing effects of MWA ( Bozaykut et al, 2016 ). Research indicates that inducing ferroptosis is a promising therapy for cancer treatment, suggesting that combining MWA with ferroptosis inducers could be a novel approach in tumor therapy ( Gai et al, 2020 ; Yu et al, 2023 ). In conclusion, the specific ablation of TAU, Shank3, and GPX4, along with utilizing MWA technology, presents new opportunities for studying ND and cancer induced by ferroptosis.…”

Section: Discussionmentioning

confidence: 99%

The research landscape of ferroptosis in neurodegenerative disease: a bibliometric analysis

Liu,

Feng,

Shui

et al. 2024

Front. Aging Neurosci.

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BackgroundFerroptosis, a newly proposed concept of programmed cell death, has garnered significant attention in research across different diseases in the last decade. Despite thorough citation analyses in neuroscience, there is a scarcity of information on ferroptosis research specifically related to neurodegenerative diseases.MethodThe Web of Science Core Collection database retrieved relevant articles and reviews. Data on publications, countries, institutions, authors, journals, citations, and keywords in the included studies were systematically analyzed using Microsoft Excel 2019 and CiteSpace 6.2.R7 software.ResultA comprehensive analysis and visualization of 563 research papers on ferroptosis in neurodegenerative diseases from 2014 to 2023 revealed emerging research hotspots and trends. The number of annual publications in this field of study has displayed a pattern of stabilization in the early years of the decade, followed by a notable increase in the later years and peaking in 2023 with 196 publications. Regarding publication volume and total citations, notable research contributions were observed from countries, institutions, and authors in North America, Western Europe, and China. Current research endeavors primarily focus on understanding the intervention mechanisms of neurodegenerative diseases through the ferroptosis pathway and exploring and identifying potential therapeutic targets.ConclusionThe study highlights key areas of interest and emerging trends in ferroptosis research on neurodegenerative diseases, offering valuable insights for further exploration and potential directions for diagnosing and treating such conditions.

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Section: Discussionmentioning

confidence: 99%

The research landscape of ferroptosis in neurodegenerative disease: a bibliometric analysis

Liu,

Feng,

Shui

et al. 2024

Front. Aging Neurosci.

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“…When local tissues are damaged, hyaluronic acid and markers of endothelial damage become exposed. This stimulates the production of chemokines and vascular adhesion molecules, which in turn recruit immune cells to the affected site ( 35 ). In a clinical study on breast cancer patients, MWA was found to significantly induce increased levels of ICOS+ activated CD4 + T cells and serum IFN-γ, indicating a multifaceted impact on the local and systemic levels beyond coagulation necrosis and protein degeneration ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer

et al. 2023

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BackgroundThermal ablation is the primary procedure for the local treatment of lung metastases. It is known that radiotherapy and cryoablation can stimulate an abscopal effect, while the occurrence of abscopal effect induced by microwave ablation is less; the cellular and molecular mechanisms involved in the abscopal effect after microwave ablation should be further elucidated.MethodsCT26 tumor-bearing Balb/c mice were treated with microwave ablation with several combinations of ablation power and time duration. The growth of primary or abscopal tumors and the survival of mice were both monitored; moreover, immune profiles in abscopal tumors, spleens, and lymph nodes were examined by flow cytometry.ResultsMicrowave ablation suppressed tumor growth in both primary and abscopal tumors. Both local and systemic T-cell responses were induced by microwave ablation. Furthermore, the mice exhibiting significant abscopal effect after microwave ablation markedly elevated Th1 cell proportion both in the abscopal tumors and spleens.ConclusionsMicrowave ablation at 3 w–3 min not only suppressed tumor growth in the primary tumors but also stimulated an abscopal effect in the CT26-bearing mice via the improvement of systemic and intratumoral antitumor immunity.

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“…In addition to heat-induced apoptosis and necrosis, Yu et al speculated that MWA might induce ferroptosis, a newly proposed type of cell death, through the induction of reactive oxygen species, p53, the heat-shock protein, and NF-E2 related factor 2 (NRF2) [49]. Accumulating evidence suggests that ferroptotic cells attract and activate innate immune cells, such as neutrophils, and are efficiently engulfed by phagocytes [50].…”

Section: Mwamentioning

confidence: 99%

Combination Therapy of Immune Checkpoint Inhibitors with Locoregional Therapy for Hepatocellular Carcinoma

Tamai,

Fujiwara,

Tanaka

et al. 2023

Cancers

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Hepatocellular carcinoma (HCC) is estimated to be the fourth leading cause of cancer-related deaths globally, and its overall prognosis is dismal because most cases are diagnosed at a late stage and are unamenable to curative treatment. The emergence of immune checkpoint inhibitors (ICIs) has dramatically improved the therapeutic efficacy for advanced hepatocellular carcinoma; however, their response rates remain unsatisfactory, partly because >50% of HCC exhibit an ICI-nonresponsive tumor microenvironment characterized by a paucity of cytotoxic T cells (immune-cold), as well as difficulty in their infiltration into tumor sites (immune excluded). To overcome this limitation, combination therapies with locoregional therapies, including ablation, transarterial embolization, and radiotherapy, which are usually used for early stage HCCs, have been actively explored to enhance ICI efficacy by promoting the release of tumor-associated antigens and cytokines, and eventually accelerating the so-called cancer–immunity cycle. Various combination therapies have been investigated in early- to late-phase clinical trials, and some have shown promising results. This comprehensive article provides an overview of the immune landscape for HCC to understand ICI efficacy and its limitations and, subsequently, reviews the status of combinatorial therapies of ICIs with locoregional therapy for HCC.

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Crosstalk between microwave ablation and ferroptosis: The next hot topic?

Cited by 6 publications

References 102 publications

The research landscape of ferroptosis in neurodegenerative disease: a bibliometric analysis

The research landscape of ferroptosis in neurodegenerative disease: a bibliometric analysis

Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer

Combination Therapy of Immune Checkpoint Inhibitors with Locoregional Therapy for Hepatocellular Carcinoma

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