Crosstalk between neurons and glia through G-protein coupled receptors: Insights from Caenorhabditis elegans

Pandey, Pallavi; Kaur, Guneet; Babu, Kavita

doi:10.1016/bs.pmbts.2022.06.005

Cited by 2 publications

(3 citation statements)

References 139 publications

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“…It is believed that almost 50% of medicines target GPCRs (Schlyer & Horuk, 2006). Glial GPCRs play key roles in the crosstalk between neurons and glia (Pandey et al., 2022), modulation of synaptic transmission at the neuromuscular junction (Colomar & Robitaille, 2004), adult neurogenesis (Doze & Perez, 2012), astrocyte‐neuron communication (Kofuji & Araque, 2020), and BBB formation (Hatan et al., 2011; Schwabe et al., 2005). In Drosophila , the expression of GPCR Moody in subperineurial glia is critical in order to maintain the integrity of BBB and modulate cocaine, nicotine, and ethanol sensitivity (Bainton et al., 2005; Schirmeier & Klämbt, 2015; Schwabe et al., 2005; Zwarts et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Miao,

Wei,

Lee

et al. 2023

J of Neuroscience Research

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Similar to the human brain, Drosophila glia may well be divided into several subtypes that each carries out specific functions. Glial GPCRs play key roles in crosstalk between neurons and glia. Drosophila Lgr4 (dLgr4) is a human relaxin receptor homolog involved in angiogenesis, cardiovascular regulation, collagen remodeling, and wound healing. A recent study suggests that ilp7 might be the ligand for Lgr4 and regulates escape behavior of Drosophila larvae. Here we demonstrate that Drosophila Lgr4 expression in glial cells, not neurons, is necessary for early development, adult behavior, and lifespan. Reducing the Lgr4 level in glial cells disrupts Drosophila development, while knocking down other LGR family members in glia has no impact. Adult‐specific knockdown of Lgr4 in glia but not neurons reduce locomotion, male reproductive success, and animal longevity. The investigation of how glial expression of Lgr4 contributes to this behavioral alteration will increase our understanding of how insulin signaling via glia selectively modulates neuronal activity and behavior.

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Section: Introductionmentioning

confidence: 99%

Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Miao,

Wei,

Lee

et al. 2023

J of Neuroscience Research

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…It is believed that almost 50% of medicines target GPCRs [10]. Glial GPCRs plays key roles in crosstalk between neurons and glia [11], modulation of synaptic transmission at the neuromuscular junction [12], adult neurogenesis [13], astrocyte-neuron communication [14], and BBB formation [15,16]. In Drosophila , the expression of GPCR Moody in subperineurial glia is critical in order to maintain the integrity of BBB and modulate cocaine, nicotine and ethanol sensitivity [15,17–19].…”

Section: Introductionmentioning

confidence: 99%

Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Lee

Kaur

Miao

et al. 2022

Preprint

View full text Add to dashboard Cite

Similar to the human brain, Drosophila glia may well be divided into several subtypes that each carry out specific functions. Glial GPCRs plays key roles in crosstalk between neurons and glia. Drosophila Lgr4 (dLgr4) is a human relaxin receptor homolog involved in angiogenesis, cardiovascular regulation, collagen remodeling, and wound healing. Recent study suggests that ilp7 might be the ligand for Lgr4 and regulates escape behavior of Drosophila larvae. Here we demonstrate that Drosophila Lgr4 expression in glial cells, not neurons, is necessary for early development, adult behavior, and lifespan. Reducing the Lgr4 level in glial cells, but not neurons, disrupts Drosophila development, although knocking down other LGR family members in glia has no impact. Adult-specific knockdown of Lgr4 in glia but not neurons reduce locomotion, male reproductive success, and animal longevity. The investigation of how glial expression of Lgr4 contributes to this behavioral alteration will increase our understanding of how insulin signaling via glia selectively modulates neuronal activity and behavior.

show abstract

Crosstalk between neurons and glia through G-protein coupled receptors: Insights from Caenorhabditis elegans

Cited by 2 publications

References 139 publications

Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

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