Crosstalk between primary and secondary metabolism: Interconnected fatty acid and polyketide biosynthesis in prokaryotes

West, Andrew B.; Bailey, Constance B.

doi:10.1016/j.bmcl.2023.129377

Cited by 4 publications

(2 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, fatty acid synthase (FAS) biosynthesizes fatty acids via Claisen-like condensations of malonyl-CoA, while polyketide synthases (PKS) share a similar biosynthetic pathway with FAS, utilizing the same precursors and cofactors. PKS also plays a pivotal role in the synthesis of secondary metabolites, such as flavonoid [31]. In our current study, we observed lower levels of secondary metabolites in the Jincha 2 cultivar compared with Wuniuzao, suggesting these synthases are more actively involved in fatty acid biosynthesis.…”

Section: Discussionsupporting

confidence: 46%

The Impact of Photosynthetic Characteristics and Metabolomics on the Fatty Acid Biosynthesis in Tea Seeds

Jiang,

Liu,

et al. 2023

Foods

View full text Add to dashboard Cite

The synthesis of tea fatty acids plays a crucial role in determining the oil content of tea seeds and selecting tea tree varieties suitable for harvesting both leaves and fruits. However, there is limited research on fatty acid synthesis in tea trees, and the precise mechanisms influencing tea seed oil content remain elusive. To reveal the fatty acid biosynthesis mechanism, we conducted a photosynthetic characteristic and targeted metabolomics analysis in comparison between Jincha 2 and Wuniuzao cultivars. Our findings revealed that Jincha 2 exhibited significantly higher net photosynthetic rates (Pn), stomatal conductance (Gs), and transpiration rate (Tr) compared with Wuniuzao, indicating the superior photosynthetic capabilities of Jincha 2. Totally, we identified 94 metabolites with significant changes, including key hormone regulators such as gibberellin A1 (GA1) and indole 3-acetic acid (IAA). Additionally, linolenic acid, methyl dihydrojasmonate, and methylthiobutyric acid, precursors required for fatty acid synthesis, were significantly more abundant in Jincha 2 compared with Wuniuzao. In summary, our research suggests that photosynthetic rates and metabolites contribute to the increased yield, fatty acid synthesis, and oil content observed in Jincha 2 when compared with Wuniuzao.

show abstract

Section: Discussionsupporting

confidence: 46%

The Impact of Photosynthetic Characteristics and Metabolomics on the Fatty Acid Biosynthesis in Tea Seeds

Jiang,

Liu,

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…These genes may possess a specialized role in polyketide synthesis. Type I and type II polyketide synthases (PKSs) share significant similarity with fatty acid synthases (FASs) [85][86][87]. This similarity complicates the determination of whether the annotation of these orthologues pertains to PKS domains mistakenly labelled as FAS or truly FAS enzymes, acting either in traditional fatty acid synthesis or in biosynthesis of natural products.…”

Section: Insights Into Actinomycetota Metabolic Adaptationsmentioning

confidence: 99%

Actinomycetota bioprospecting from ore-forming environments

Aguilar,

Alwali,

Mair

et al. 2024

Microbial Genomics

View full text Add to dashboard Cite

Natural products from Actinomycetota have served as inspiration for many clinically relevant therapeutics. Despite early triumphs in natural product discovery, the rate of unearthing new compounds has decreased, necessitating inventive approaches. One promising strategy is to explore environments where survival is challenging. These harsh environments are hypothesized to lead to bacteria developing chemical adaptations (e.g. natural products) to enable their survival. This investigation focuses on ore-forming environments, particularly fluoride mines, which typically have extreme pH, salinity and nutrient scarcity. Herein, we have utilized metagenomics, metabolomics and evolutionary genome mining to dissect the biodiversity and metabolism in these harsh environments. This work has unveiled the promising biosynthetic potential of these bacteria and has demonstrated their ability to produce bioactive secondary metabolites. This research constitutes a pioneering endeavour in bioprospection within fluoride mining regions, providing insights into uncharted microbial ecosystems and their previously unexplored natural products.

show abstract

In-situ treatment of gaseous benzene in fixed-bed biofilter with polyurethane foam: Functional population response and benzene transformation pathway

Wang,

Zhang,

Gao

et al. 2024

Bioresource Technology

View full text Add to dashboard Cite

Crosstalk between primary and secondary metabolism: Interconnected fatty acid and polyketide biosynthesis in prokaryotes

Cited by 4 publications

References 65 publications

The Impact of Photosynthetic Characteristics and Metabolomics on the Fatty Acid Biosynthesis in Tea Seeds

The Impact of Photosynthetic Characteristics and Metabolomics on the Fatty Acid Biosynthesis in Tea Seeds

Actinomycetota bioprospecting from ore-forming environments

In-situ treatment of gaseous benzene in fixed-bed biofilter with polyurethane foam: Functional population response and benzene transformation pathway

Contact Info

Product

Resources

About