Crosstalk between SOX Genes and Long Non-Coding RNAs in Glioblastoma

Abstract

Glioblastoma (GBM) continues to be the most devastating primary brain malignancy. Despite significant advancements in understanding basic GBM biology and enormous efforts in developing new therapeutic approaches, the prognosis for most GBM patients remains poor with a median survival time of 15 months. Recently, the interplay between the SOX (SRY-related HMG-box) genes and lncRNAs (long non-coding RNAs) has become the focus of GBM research. Both classes of molecules have an aberrant expression in GBM and play essential roles in tumor initiation, progression, therapy resistance, and recurrence. In GBM, SOX and lncRNAs crosstalk through numerous functional axes, some of which are part of the complex transcriptional and epigenetic regulatory mechanisms. This review provides a systematic summary of current literature data on the complex interplay between SOX genes and lncRNAs and represents an effort to underscore the effects of SOX/lncRNA crosstalk on the malignant properties of GBM cells. Furthermore, we highlight the significance of this crosstalk in searching for new biomarkers and therapeutic approaches in GBM treatment.

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

“…The scientists discovered that SOX2-OT comprises a minimum of five exons (latest investigations estimate it possibly includes hundreds of exons) and produces an mRNA-like transcript on the same strand as SOX2. (Fantes et al, 2003b) (Stevanovic et al, 2023). The corresponding transcript is evolutionarily preserved, with the human SOX2-OT transcripts accessible through mouse expression sequence tags sharing 80% nucleotide identity.…”

“…(Fantes et al, 2003b). Furthermore, the genomic region encompassing the SOX2-OT transcription unit (about 40 kb) is highly conserved across vertebrates (Fantes et al, 2003b) (Stevanovic et al, 2023). Currently, there are only a few investigations on SOX2OT genomic mutations.…”