Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases

Ahmad, Ajmal; Braden, Anneliesse; Khan, Sazzad; Xiao, Jianfeng; Khan, Mohammad Moshahid

doi:10.1007/s00281-024-01016-7

Semin Immunopathol

2024

DOI: 10.1007/s00281-024-01016-7

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Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases

Ajmal Ahmad,

Anneliesse Braden,

Sazzad Khan

et al.

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Cited by 2 publications

References 149 publications

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The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases

Zhang,

Zou,

et al. 2024

Neurobiology of Disease

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The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases

Zhang,

Zou,

et al. 2024

Neurobiology of Disease

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From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Saliev,

Singh

2024

Cells

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Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, and cellular senescence—these therapies aim to restore youthful functionality to cells and tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased a range of strategies, including epigenetic reprogramming, senolytic interventions, mitochondrial restoration, stem cell-based approaches, and gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential in preclinical models and is now being cautiously explored in early-stage clinical trials. However, translating these therapies from the laboratory to clinical practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, and high costs impede widespread adoption. This review examines the current landscape of cellular rejuvenation, highlighting key advancements, potential risks, and the strategies needed to overcome these hurdles.

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Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases

Cited by 2 publications

References 149 publications

The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases

The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases

From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

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