Crosstalks between kisspeptin neurons and somatostatin neurons are not photoperiod dependent in the ewe hypothalamus

Dufourny, Laurence; Lomet, Didier

doi:10.1016/j.ygcen.2017.09.017

Cited by 8 publications

(10 citation statements)

References 33 publications

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“…206 By contrast, infusion of the nitric oxide inhibitor, l-N G -nitro arginine methyl ester, into the lateral ventricle completely blocked the LH surge in ewes, 162 although this study involved a limited number of animals and needs to be confirmed by other approaches. There is strong evidence that KNDy neurons in sheep project to GnRH cell bodies in the MBH and POA, 60,141 GnRH fibers in the median eminence 63 and the POA kisspeptin population, 60 but not to SST-nNOS cells in the VMN, 207 and these SST-nNOS neurons likely project to GnRH neurons, 162,208 as well as both populations of kisspeptin cells. 162,207,208 By contrast, the POA kisspeptin population projects to GnRH cells, 60 but not KNDy 60 or SST-nNOS 207 neurons.…”

Section: Other Spontaneous Ovulatorsmentioning

confidence: 99%

Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion

Goodman

Herbison

Lehman

et al. 2022

J Neuroendocrinology

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The concept that tonic luteinising hormone (LH) secretion and the LH surge are controlled by largely separate mechanisms was first proposed by Everett and Sawyer in 1949 1 and received convincing support from the pioneering work of Halasz and Gorski in the 1960s. 2This model was generally accepted when gonadotropin-releasing hormone (GnRH) was identified as the hypothalamic hormone controlling gonadotropin secretion, and so it is not surprising that it established important parameters for studies of the GnRH neural

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Section: Other Spontaneous Ovulatorsmentioning

confidence: 99%

Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion

Goodman

Herbison

Lehman

et al. 2022

J Neuroendocrinology

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“…GABA is a major inhibitory neurotransmitter in animals, and can inhibit the synthesis of GnRH and regulate HPGA [11,37]. The neurons of Kiss1 are mainly distributed in the anterior ventral ventricular nucleus (AVPV) and ARC of the hypothalamus [38] and ARC is a key site for kisspeptin to regulate the release of GnRH pulse [37,39,40]. Kisspeptin and GABA can provide an excitatory input to GnRH neurons when co-expressed by RP3V neurons [41].…”

Section: Discussionmentioning

confidence: 99%

Effect of GABA-T on Reproductive Function in Female Rats

Kang

et al. 2020

Animals

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This study explored the role of γ-aminobutyric acid transaminase (GABA-T) in the puberty and reproductive performance of female rats. Immunofluorescence technique, quantitative real-time PCR (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA) were used to detect the distribution of GABA-T and the expression of genes and hormones in female rats, respectively. The results showed that GABA-T was mainly distributed in the arcuate nucleus (ARC), paraventricular nucleus (PVN) and periventricular nucleus (PeN) of the hypothalamus, and in the adenohypophysis, ovarian granulosa cells and oocytes. Abat mRNA level at 28 d was lowest in the hypothalamus and the pituitary; at puberty, it was lowest in the ovary. Abat mRNA level was highest in adults in the hypothalamus; at infancy and puberty, it was highest in the pituitary; and at 21 d it was highest in the ovary. After vigabatrin (GABA-T irreversible inhibitor) was added to hypothalamus cells, the levels of Abat mRNA and Rfrp-3 mRNA were significantly reduced, but Gnrh mRNA increased at the dose of 25 and 50 μg/mL; Kiss1 mRNA was significantly increased but Gabbr1 mRNA was reduced at the 50 μg/mL dose. In prepubertal rats injected with vigabatrin, puberty onset was delayed. Abat mRNA, Kiss1 mRNA and Gnrh mRNA levels were significantly reduced, but Rfrp-3 mRNA level increased in the hypothalamus. Vigabatrin reduced the concentrations of GABA-T, luteinizing hormone (LH) and progesterone (P4), and the ovarian index. Lactation performance was reduced in adult rats with vigabatrin treatment. Four hours after vigabatrin injection, the concentrations of GABA-T and LH were significantly reduced in adult and 25 d rats, but follicle-stimulating hormone (FSH) increased in 25 d rats. In conclusion, GABA-T affects the reproductive function of female rats by regulating the levels of Gnrh, Kiss1 and Rfrp-3 in the hypothalamus as well as the concentrations of LH and P4.

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“…Recently, a study demonstrated that E2 has a conspicuous influence on a population of neurons expressing SOM in three diencephalic areas involved in the central control of sexual behavior: the ARC, the POA, and the ventrolateral part of the VMHvl, (Dufourny & Lomet, 2017). Despite how E2 affects GH secretion is unclear and data demonstrating the effect of E2 in the fetal hypothalamus are missing, these finding could be of economic importance in domestic cetartiodactyl species, particularly during early pregnancy when the embryonic loss may reach 25-40% of cattle, sheep, and swine pregnancies, and up to 50% of alpaca pregnancies (Bravo, Diaz, Alarcón, & Ordoñez, 2010).…”

Section: Distribution Of P450arom-ir During Early Morphogenesis and In The Newborn Alpaca Hypothalamusmentioning

confidence: 99%

“…Recently, a study demonstrated that E2 has a conspicuous influence on a population of neurons expressing the peptide hormone somatostatin (SOM) in three diencephalic areas involved in the central control of sexual behavior: the arcuate nucleus (ARC), the preoptic area (POA) and the ventrolateral part of the ventromedial hypothalamus (VMHvl; Dufourny & Lomet, 2017).…”

Section: Introductionmentioning

confidence: 99%

Neurochemical characterization of the hypothalamus of the early fetal and newborn alpaca Vicugna pacos

Montelli

Graïc

Ruiz

et al. 2019

The Anatomical Record

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In this study we performed a neurochemical characterization of the hypothalamus in the developing alpaca (Vicugna pacos) with the aim of revealing the distributions of immunoreactive (-ir) cells containing parvalbumin (PV), calbindin (CB), calretinin (CR), the somatostatin (SOM), the enzyme aromatase P450 (P450Arom), the estrogen receptor α (ER-α), and estrogen receptor β (ER-β) in embryonal stages, early fetal age, and in the newborn. This analysis has been carried out on embryos at 20, 30, 45 days, fetuses at 90 days, and newborn alpaca. Our immunohistochemical results revealed no cells-ir throughout the embryonic hypothalami of 20, 30, and 45 days. On the fetal stage of 90 days, SOM-ir cells were observed in the lateral hypothalamus and the ventromedial nuclei of the tuberal region. We checked for the presence of P450Arom-ir cells in the periventricular area and dorsomedial hypothalamic nucleus of the tuberal region. In these fetal stages, no PV-ir, CB-ir, CR-ir or ERs-ir cells were identified. In the newborn, the PV-ir, CB-ir, CR-ir, and SOMir cells were detected in both the anterior and tuberal hypothalamic area. The P450Arom-ir cells the ER-α-ir and ER-β-ir cells were found in the anterior hypothalamus. Our results offer a contribution in the future purpose to obtain a time-expression pattern of the considered markers in alpaca during gestation and represents a foundation for future investigations on the alpaca brain to define the cross talk between PV, CB, CR, P450Arom, SOM, and ERs in the hypothalamus, the strategic region for the control of the reproductive behavior.

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Crosstalks between kisspeptin neurons and somatostatin neurons are not photoperiod dependent in the ewe hypothalamus

Cited by 8 publications

References 33 publications

Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion

Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion

Effect of GABA-T on Reproductive Function in Female Rats

Neurochemical characterization of the hypothalamus of the early fetal and newborn alpaca Vicugna pacos

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