2022
DOI: 10.1101/2022.07.29.502035
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Crowding-induced phase separation and solidification by co-condensation of PEG in NPM1-rRNA condensates

Abstract: The crowdedness of the cell calls for adequate intracellular organization. Biomolecular condensates, formed by liquid-liquid phase separation of intrinsically disordered proteins and nucleic acids, are important organizers of cellular fluids. To underpin the molecular mechanisms of protein condensation, cell-free studies are often used where the role of crowding is not investigated in detail. Here, we investigate the effects of macromolecular crowding on the formation and material properties of a model heterot… Show more

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