Crown ether–ionic liquid-based extraction chromatographic resin for separation of 90Y from 90Sr

Zou, Yu; Liang, Juncheng; Chu, Taiwei

doi:10.1007/s10967-016-5142-5

Cited by 14 publications

(1 citation statement)

References 26 publications

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“…The United States-food and drug administration (US-FDA) has accepted Zevalin drug that incorporates 90 Y [ 7 , 8 ]. So, it is essential to the 90 Sr impurity in 90 Y samples owing to the radiotoxicity of 90 Sr [ 9 , 10 ]. 90 Y decays to the stable 90 Zr daughter, thus it is used as a pure β -emitter.…”

Section: Introductionmentioning

confidence: 99%

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

El-Shahawi,

Alwael,

Alsibaai

et al. 2024

International Journal of Analytical Chemistry

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There is growing demand for separation of 90Y carrier free from 90Sr coexisting to produce high purity 90Y essential for radiopharmaceutical uses. Thus, in this context the sorption profiles of Y3+ and Sr2+ from aqueous solutions containing diethylenetriaminepenta acetic acid (DTPA), ethylenediaminetetra-acetic acid (EDTA), acetic acid, citric acid, or NaCl onto Chelex-100 (anion ion exchange) solid sorbent were critically studied for developing an efficient and low-cost methodology for selective separation of Y3+ from Sr2+ ions (1.0 × 10−5 M). Batch experiments displayed relative chemical extraction percentage (98 ± 5.4%) of Y3+ from aqueous acetic acid solution onto Chelex-100 (anion ion exchanger), whereas Sr2+ species showed no sorption. Hence, a selective separation of Y3+ from its parent 90Sr2+ has been established based upon percolation of the aqueous solution of Y3+ and Sr2+ ions containing acetic acid at pH 1-2 through Chelex-100 sorbent packed column at a 2 mL min−1 flow rate. Y3+ species were retained quantitatively while Sr2+ ions were not sorbed and passed through the sorbent packed column without extraction. The sorbed Y3+ species were then recovered from the sorbent packed column with HNO3 (1.0 M) at a 1.0 mL min−1 flow rate. A dual extraction mechanism comprising absorption associated to “weak-base anion exchanger” and “solvent extraction” of Y3+ as (YCl6)3− and an extra part for “surface adsorption” of Y3+ by the sorbent is proposed. The established method was validated by measuring the radiochemical (99.2 ± 2 1%), radionuclide purity and retardation factor (Rf = 10.0 ± 0.1 cm) of 90Y3+ recovered in the eluate. Ultimately, the sorbent packed column also presented high stability for reusing 2-3 cycles without drop in its efficiency (±5%) towards Y3+ uptake and relative chemical recovery. A proposed flow sheet describing the analytical procedures for the separation of 90Y3+ from 90Sr2+ using chelating Chelex 100 (anion exchange) packed column is also included.

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Section: Introductionmentioning

confidence: 99%

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

El-Shahawi,

Alwael,

Alsibaai

et al. 2024

International Journal of Analytical Chemistry

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Cyphos Nitrate Selectively Separates Y(III) from Sr(II) Present in Acidic Feed Solution: An Efficient Ionic Liquid based Extraction Process

Rout,

Sriram,

Ramanathan

2024

ChemistrySelect

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Mutual separation of Y(III) and Sr(II) from their waste solution has been an emerging research domain due to their various industrial applications. In this investigation, we emphasize the feasibility of selective separation of Y(III) from Sr(II) present in nitric acid medium using undiluted cyphos nitrate ionic liquid (IL): trihexyl(tetradecyl)phosphonium nitrate ([P66614][NO3]) as the ligating phase. The set experimental parameters were the feed phase acidity, initial nitrate ion concentration, initial feed metal ion concentration, equilibration time and temperature to unveil the efficacy of the proposed system. Efficient extraction of Y(III) selectively in presence of Sr(II) using only a salting agent in aqueous phase without additional extractant in IL phase was highlighted. A remarkable separation factor (SF) obtained for Y(III) over Sr(II) explored the efficacy of the proposed IL system. Y(III) loading in IL phase both in unirradiated and irradiated conditions was compared to evaluate the coordination behavior of irradiated moieties. In addition, a most important advantage of the proposed system is that it employs Milli‐Q water for the back extraction (stripping) of the loaded Y(III) from IL phase and does not demand any complexing agent (water soluble). This undoubtedly corroborates the economic and environmental benefits of the proposed IL system.

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Radiochemical investigation of 90Y separation from 90Sr and 90Y mixture with D2EHPA-St-DVB extractant polymer resin

Im¹,

Pak²,

Kim³

2021

J Radioanal Nucl Chem

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Crown ether–ionic liquid-based extraction chromatographic resin for separation of 90Y from 90Sr

Cited by 14 publications

References 26 publications

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

Sorption Characteristics and Chromatographic Separation of 90Y3+ from 90Sr2+ from Aqueous Media by Chelex-100 (Anion Ion Exchange) Packed Column

Cyphos Nitrate Selectively Separates Y(III) from Sr(II) Present in Acidic Feed Solution: An Efficient Ionic Liquid based Extraction Process

Radiochemical investigation of 90Y separation from 90Sr and 90Y mixture with D2EHPA-St-DVB extractant polymer resin

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