Crown Ethers

Gokel, George W.; Negin, Saeedeh; Cantwell, Ryan

doi:10.1016/b978-0-12-409547-2.12519-3

Cited by 12 publications

(4 citation statements)

References 180 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of types of neutral fluorescent cyclophanes is considerable. 178 For example, crown ethers 179 bearing aromatic rings, such as the widely known, dibenzo[24]crown-8, are cyclophanes. Thus, emissive crown ether cyclophanes possessing fluorophores in their core 180 or as pendant groups 181 have been designed and applied in the creation of probes 182 and supramolecular polymers.…”

Section: Different Types Of Fluorescent Cyclophanesmentioning

confidence: 99%

Fluorescent cyclophanes and their applications

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Different Types Of Fluorescent Cyclophanesmentioning

confidence: 99%

Fluorescent cyclophanes and their applications

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The field of synthetic enzymes is rapidly growing. Cyclodextrins, 29,41 crown ethers, 42 metalloporphyrins, 43 molecularly imprinted polymers 44,45 and other materials 46–48 have shown enzyme-like activities. These catalysts are generally more stable than natural enzymes and capable of functioning under a wide range of conditions.…”

Section: Introductionmentioning

confidence: 99%

Opportunities and challenges for plastic depolymerization by biomimetic catalysis

Wu,

Hu,

Che

et al. 2024

Chem. Sci.

View full text Add to dashboard Cite

show abstract

“…Owing to these properties, the indicated macrocycles are rather often utilized for targeted delivery of antitumor and antimicrobial agents and polyfunctional molecules exhibiting multitarget properties. Polyether macrocycles can affect the enzymatic activity, interact with DNA, cleave DNA, and also act as antibacterial agents. − …”

Section: Introductionmentioning

confidence: 99%

New Polyether Macrocycles as Promising Antitumor Agents─Targeted Synthesis and Induction of Mitochondrial Apoptosis

Islamov,

Dzhemileva,

Gaisin

et al. 2024

ACS Omega

View full text Add to dashboard Cite

A series of previously unknown aromatic polyether macrodiolides containing a cis,cis-1,5-diene moiety in the molecule were synthesized in 47−74% yields. Macrocycle compounds were first obtained by intermolecular esterification of aromatic polyether diols with α,ω-alka-nZ,(n+4)Z-dienedioic acids mediated by N-(3-(dimethylamino)propyl)-N′-ethylcarbodiimide hydrochloride (EDC•HCl) and 4-(dimethylamino)pyridine (DMAP). For the synthesized compounds, studies of cytotoxicity on tumor (Jurkat, K562, U937), conditionally normal (HEK293) cell lines, and normal fibroblasts were carried out. CC50 was determined, and the therapeutic selectivity index of cytotoxic action (SI) in comparison with normal fibroblasts was evaluated. With the involvement of modern methods of flow cytometry for the most promising macrocycles, their effect on mitochondria and the cell cycle was investigated. It was found that a new macrocycle exhibits pronounced apoptosis-inducing activity toward Jurkat cells and can retard cell division by blocking at the G1/S checkpoint. Also, it was shown that the synthesized macrodiolides influence mitochondria due to their high ability to penetrate the mitochondrial membrane.

show abstract

Crown Ethers

Cited by 12 publications

References 180 publications

Fluorescent cyclophanes and their applications

Fluorescent cyclophanes and their applications

Opportunities and challenges for plastic depolymerization by biomimetic catalysis

New Polyether Macrocycles as Promising Antitumor Agents─Targeted Synthesis and Induction of Mitochondrial Apoptosis

Contact Info

Product

Resources

About