Crown-like Structures in Breast Adipose Tissue from Normal Weight Women: Important Impact

Berger, Nathan A.

doi:10.1158/1940-6207.capr-17-0062

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…35,36 Breast adipose tissue inflammation is associated with elevated aromatase levels, the rate-limiting enzyme in estrogen biosynthesis, 37 and similar inflammation has been noted at distant sites. 38,39 Thus increased estrogen production arising from aromatase activity, particularly in the postmenopausal environment, may selectively drive proliferation in estrogen-dependent breast cancer. Biosynthesis of estrogen may also reduce the effectiveness of endocrine therapy among obese women with hormone-positive subtypes.…”

Section: Discussionmentioning

confidence: 99%

Obesity and survival among a cohort of breast cancer patients is partially mediated by tumor characteristics

et al. 2019

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Obesity exerts adverse effects on breast cancer survival, but the means have not been fully elucidated. We evaluated obesity as a contributor to breast cancer survival according to tumor molecular subtypes in a population-based case–cohort study using data from the Surveillance Epidemiology and End Results (SEER) program. We determined whether obese women were more likely to be diagnosed with poor prognosis tumor characteristics and quantified the contribution of obesity to survival. Hazard ratios (HRs) and 95% confidence intervals (CI) were calculated via Cox multivariate models. The effect of obesity on survival was evaluated among 859 incident breast cancers (subcohort; 15% random sample; median survival 7.8 years) and 697 deaths from breast cancer (cases; 100% sample). Obese women had a 1.7- and 1.8-fold increased risk of stage III/IV disease and grade 3/4 tumors, respectively. Obese women with Luminal A- and Luminal B-like breast cancer were 1.8 (95% CI 1.3–2.5) and 2.2 (95% CI 0.9–5.0) times more likely to die from their cancer compared to normal weight women. In mediation analyses, the proportion of excess mortality attributable to tumor characteristics was 36.1% overall and 41% and 38% for Luminal A- and Luminal B-like disease, respectively. Obesity was not associated with breast cancer-specific mortality among women who had Her2-overexpressing or triple-negative tumors. Obesity may influence hormone-positive breast cancer-specific mortality in part through fostering poor prognosis tumors. When tumor biology is considered as part of the causal pathway, the public health impact of obesity on breast cancer survival may be greater than previously estimated.

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Section: Discussionmentioning

confidence: 99%

Obesity and survival among a cohort of breast cancer patients is partially mediated by tumor characteristics

et al. 2019

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“…Crown-like structures (CLSs), composed of macrophages encapsulating dead or dying adipocytes, are a histologic hallmark of the pro-inflammatory process. In this process, adipose tissue contributes to the increased risk and worse prognosis of BC in obese, postmenopausal patients as well as some normal-weight women [ 99 ]. CD68 + and/or CD163 + TAM infiltration, coupled with CLSs, is present in adipose tissue nearby the BC lesion, and is associated with various clinicopathologic parameters of BC [ 17 ].…”

Section: Adipocytes and Breast Cancermentioning

confidence: 99%

Cancer-associated adipocytes: emerging supporters in breast cancer

Zhao

Zeng

et al. 2020

J Exp Clin Cancer Res

120

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Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis and recurrence rate, and adipocytes are the largest components in breast tissue. The aberrant adipocytes, especially the BC-neighbored cancer-associated adipocytes (CAAs), are found in the invasive front of BC. CAAs present a vicious phenotype compared with mature mammary adipocytes and mediate the crosstalk network between adipocytes and BC cells. By releasing multiple adipokines such as leptin, adiponectin, interleukin (IL)-6, chemokine ligand 2 (CCL2) and chemokine ligand 5 (CCL5), CAAs play essential roles in favor of proliferation, angiogenesis, dissemination, invasion and metastasis of BC. This article reviews the recent existing CAAs studies on the functions and mechanisms of adipocytes in the development of BC, including adipokine regulating, metabolic reprogramming, extracellular matrix (ECM) remodeling, microRNAs (miRNAs) and immune cell adjusting. Besides, adipocyte secretome and cellular interactions are implicated in the intervention to BC therapy and autologous fat grafting of breast reconstruction. Therefore, the potential functions and mechanisms of CAAs are very important for unveiling BC oncogenesis and progress. Deciphering the complex network between CAAs and BC is critical for designing therapeutic strategies and achieving the maximum therapeutic effects of BC.

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“…Moreover, inflammatory factors (e.g., IL-6, IL-1β, TNF-α) are found at high levels in obese patients and are associated with poor outcome in BC patients [98]. The presence of CLSs is not limited to obese patients, but it also occurs in BCs from normal weight women [99]. Tumor trace released on adipocytes provides important modifications of fat cell secretome, which, generally speaking, becomes highly inflammatory.…”

Section: Inflammationmentioning

confidence: 99%

Adipocytes in Breast Cancer, the Thick and the Thin

Rybińska

Agresti

Trapani

et al. 2020

Cells

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It is well established that breast cancer development and progression depend not only on tumor-cell intrinsic factors but also on its microenvironment and on the host characteristics. There is growing evidence that adipocytes play a role in breast cancer progression. This is supported by: (i) epidemiological studies reporting the association of obesity with a higher cancer risk and poor prognosis, (ii) recent studies demonstrating the existence of a cross-talk between breast cancer cells and adipocytes locally in the breast that leads to acquisition of an aggressive tumor phenotype, and (iii) evidence showing that cancer cachexia applies also to fat tissue and shares similarities with stromal-carcinoma metabolic synergy. This review summarizes the current knowledge on the epidemiological link between obesity and breast cancer and outlines the results of the tumor-adipocyte crosstalk. We also focus on systemic changes in body fat in patients with cachexia developed in the course of cancer. Moreover, we discuss and compare adipocyte alterations in the three pathological conditions and the mechanisms through which breast cancer progression is induced.

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Crown-like Structures in Breast Adipose Tissue from Normal Weight Women: Important Impact

Cited by 12 publications

References 31 publications

Obesity and survival among a cohort of breast cancer patients is partially mediated by tumor characteristics

Obesity and survival among a cohort of breast cancer patients is partially mediated by tumor characteristics

Cancer-associated adipocytes: emerging supporters in breast cancer

Adipocytes in Breast Cancer, the Thick and the Thin

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