Crown years for non-invasive cardiovascular imaging (Part IV): 30 years of cardiac computed tomography

Wall, Ernst E. van der

doi:10.1007/s12471-013-0427-6

Cited by 8 publications

(6 citation statements)

References 58 publications

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“…In particular, when the ascending aorta appears large at echocardiography, it is important to evaluate progression of the aortic diameters with CMR as standard care [ 7 , 8 ]. At present, multi-slice computed tomography (MSCT) is increasingly used for sizing TAV and BAV through noninvasive evaluation of the aortic root [ 9 – 11 ]. However, the true gold standard for assessing these stenotic valves appears to be the appraisal of the surgeon.…”

Section: Optimal Diagnosismentioning

confidence: 99%

Bicuspid aortic valve; optimal diagnosis and latest interventional treatment

Wall

2015

Neth Heart J

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Section: Optimal Diagnosismentioning

confidence: 99%

Bicuspid aortic valve; optimal diagnosis and latest interventional treatment

Wall

2015

Neth Heart J

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“…Quantification of coronary artery calcium by computed tomography represents a reliable estimate of atherosclerotic plaque burden and the prognostic value of the coronary artery calcium score (CACS) is well established [ 1 , 2 ]. Recently, coronary computed tomographic angiography (CCTA) has emerged as an important imaging tool to detect the presence and extent of coronary artery disease (CAD) [ 3 , 4 ]. Several large prospective trials have demonstrated the prognostic value of CCTA, with a high negative predictive value for the occurrence of major adverse cardiac events (MACE) [ 5 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Independent prognostic value of coronary artery calcium score and coronary computed tomography angiography in an outpatient cohort of low to intermediate risk chest pain patients

et al. 2016

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BackgroundLimited studies report on the additional prognostic value of coronary computed tomography angiography (CCTA) and the coronary artery calcium score (CACS).MethodsFor a median of 637 days, 1551 outpatients with chest pain, without known coronary artery disease (CAD) and low or intermediate pre-test probability of CAD, were followed for major adverse cardiac events (MACE), defined as death, myocardial infarction or late revascularisation. Cox proportional hazard regression was used to evaluate the independent prognostic value of CCTA and CACS.ResultsMACE occurred in 23 patients (1.5 %): death (3, 0.2 %), myocardial infarction (4, 0.3 %) and late revascularisation (16, 1.3 %). Multivariate analysis showed an independent prognostic value of CCTA (p < 0.001), CACS of 100–400 (p = 0.035) and CACS of > 400 (p = 0.021). CCTA showed obstructive CAD in 3.1 % of patients with CACS = 0. No events occurred in patients with CACS = 0 without obstructive CAD at CCTA, whereas 2/23 patients (9 %) with CACS = 0 with obstructive CAD had a MACE.ConclusionsOur study shows that both CCTA and higher CACS categories have independent prognostic value in chest pain patients with low to intermediate pre-test probability of obstructive CAD, in which CCTA is appropriate. Furthermore a non-negligible amount of patients with CACS = 0 have obstructive CAD at CCTA. CCTA can be used in these patients to identify those at risk for MACE.

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“…Coronary CT (CCT) can be of added value by providing a minimally invasive opportunity to image the coronary arteries for coronary artery calcium (CAC), atherosclerotic burden and coronary stenosis [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Rationale and design of the Measuring Athlete’s Risk of Cardiovascular events (MARC) study

et al. 2014

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BackgroundMore than 90 % of exercise-related cardiac arrests occur in men, predominantly those aged 45 years and older with coronary artery disease (CAD) as the main cause. The current sports medical evaluation (SME) of middle-aged recreational athletes consists of a medical history, physical examination, and resting and exercise electrocardiography. Coronary CT (CCT) provides a minimally invasive low radiation dose opportunity to image the coronary arteries. We present the study protocol of the Measuring Athlete’s Risk of Cardiovascular events (MARC) study. MARC aims to assess the additional value of CCT to a routine SME in asymptomatic sportsmen ≥45 years without known CAD.DesignMARC is a prospective study of 300 asymptomatic sportsmen ≥45 years who will undergo CCT if the SME does not reveal any cardiac abnormalities. The prevalence and determinants of CAD (coronary artery calcium score ≥100 Agatston Units (AU) or ≥50 % luminal stenosis) will be reported. The number needed to screen to prevent the occurrence of one cardiovascular event in the next 5 years, conditional to adequate treatment, will be estimated.DiscussionWe aim to determine the prevalence and severity of CAD and the additional value of CCT in asymptomatic middle-aged (≥45 years) sportsmen whose routine SME revealed no cardiac abnormalities.Electronic supplementary materialThe online version of this article (doi:10.1007/s12471-014-0630-0) contains supplementary material, which is available to authorized users.

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Crown years for non-invasive cardiovascular imaging (Part IV): 30 years of cardiac computed tomography

Cited by 8 publications

References 58 publications

Bicuspid aortic valve; optimal diagnosis and latest interventional treatment

Bicuspid aortic valve; optimal diagnosis and latest interventional treatment

Independent prognostic value of coronary artery calcium score and coronary computed tomography angiography in an outpatient cohort of low to intermediate risk chest pain patients

Rationale and design of the Measuring Athlete’s Risk of Cardiovascular events (MARC) study

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