CRP as an Inflammatory Marker in Oral Rinses

Abstract

Poster Presentations P153 POSTERSexposure, radiologic findings of calcification and increased vascularity, age, and gender.Results: A total of 378 cases were eligible for review. Of these, one-third met inclusion criteria. Cytology characterized as malignant or benign were found to have high concordance with surgical pathology findings. The diagnosis atypia of undetermined significance (AUS) and its malignancy risk were observed 2 to 3 times higher than that prescribed by the Bethesda guidelines. The majority of cases with cytologic features of follicular neoplasm were found to be benign. However, a significant number of incidental cases of papillary microcarcinoma were observed within this group. Papillary thyroid carcinoma was identified in 60% of cases with features suspicious for malignancy. Conclusion:While benign and malignant cytologies are highly predictive, there exists wide variation in the interpretation of uncertain categories. Malignancy risk associated with AUS ranges from 6% to 28% in the literature. These results suggest that trends developed from institution-specific data may be more predictive in guiding post-FNA management. Method: ELISA will be used to measure IL-6 release from MSK-Leuk1 treated with varying concentrations of CRP and pioglitazone. ELISA will be used to measure CRP in oral rinses of control patients. Two-sided t test and ANOVA are used for analysis of results with significance level of 5%. Head and Neck SurgeryResults: When treated with CRP (0.001-10 ug/mL), MSKLeuk1 cells increased IL-6 release in a dose-dependent manner (P < .05). When treated with CRP (0.01-10 ug/mL) and with pioglitazone (10 uM) MSK-Leuk1 cells released a statistically significantly decrease in IL-6 as compared to CRP treatment (P < .05) Oral rinses were easily collected and CRP was measured by ELISA to establish controls for an ongoing study of pioglitazone treatment of leukoplakia and CRP as an affective inflammatory marker. Conclusion:CRP is now shown to play an active roll in increasing the inflammatory cascade in leukoplakia cells, and pioglitazone attenuates this stimulation as measured by IL-6. The next step is to test CRP in already collected oral rinses of leukoplakia patients before and after treatment with pioglitazone. Objective: To analyze the dental health of head and neck cancer patients who received comprehensive dental care before and after radiation. Head and Neck SurgeryMethod: Retrospective study of 282 head and neck cancer patients at a single VA hospital who were treated with radiation between 2000 and 2010 were identified. All patients received conventional radiation therapy (RT) or intensitymodulated radiation therapy (IMRT).Results: A complete dental evaluation was performed prior to radiation treatment, including periodontal probing, tooth profile, cavity check, and mobility. The treatment plan was formulated to eliminate current and potential dental disease, as well as prepare for future dental rehabilitation. The rates of dental extractions, infections, and caries were analyzed ...