Crucial parameter of the outcome in Crimean Congo hemorrhagic fever: Viral load

Hasanoğlu, İmran; Güner, Rahmet; Çarhan, Ahmet; Tufan, Zeliha Koçak; Yağcı-Çağlayık, Dilek; Güven, Tümer; Yilmaz, Gül Ruhsar; Taşyaran, Mehmet A.

doi:10.1016/j.jcv.2015.12.006

Cited by 31 publications

(38 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Being able to predict the clinical course of the disease makes physicians more prepared for management of the patient, thus, can be lifesaving. However, no other criteria is as correlated with mortality as viral load or viral clearance . Viral load with a cut off value 10 8 copies/mL is found to be a strong predictor of survival with high sensitivity .…”

Section: Discussionmentioning

confidence: 90%

“…Independent from the outcome, worse clinical course such as bleeding, multiorgan failure, seizure, need for hemodialysis were statistically significantly seen more in patients with high viral load. Moreover, it is significantly correlated with routine laboratory parameters of CCHF . Therefore, it is essential to consider viral clearance for predicting the course of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…There are limited studies on viral load in CCHF and all state that high viral load is strongly correlated with fatal outcome. 9,10,17 In our previous study, which has the largest number of patients evaluating viral load in CCHF, the most important prognostic factor was found to be the viral load with a cut-off value of 10 8 copy/mL and it is correlated with severe clinical presentation. 9 inducing coagulopathy, shock, and organ failure.…”

Section: Introductionmentioning

confidence: 87%

“…Most of these are based on clinical features and routine laboratory parameters. However, recent studies revealed that viral load is the most important prognostic factor in CCHF . Immune system and the host response play critical role in determining the course of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…However, recent studies revealed that viral load is the most important prognostic factor in CCHF. [9][10][11] Immune system and the host response play critical role in determining the course of the disease. There are a few studies on the dynamics of viral load in CCHF.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dynamics of viral load in Crimean Congo hemorrhagic fever

Hasanoğlu

Güner

Çarhan

et al. 2017

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

Crimean Congo hemorrhagic fever (CCHF) is a viral zoonotic disease with high mortality rate. There are only a few studies on viral load in CCHF. In our study, we revealed the dynamics of viral load and its relationship with mortality in early phase of the disease. A total of 138 serum samples were collected from 23 patients. All patients had positive PCR for CCHF on admission. Serum samples were obtained daily from all patients for the first 6 days of hospitalization and stored at -80°C for viral load measurement. We found statistically significant difference between mean number of viremic serum samples of fatal and non-fatal patients. Furthermore, non-fatal cases' viral loads demonstrated statistically significant decreases over time; however, we could not observe a similar trend in viral loads of fatal cases. Limited number of studies on CCHF indicate that score of the contest between CCHF virus and immune system determines the survival in CCHF and viral load is found to be the most prognostic factor. In our study, we found that there is a notable decrease trend in viral loads of non-fatal patients over time and this clearance of CCHF virus is significantly related with survival.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dynamics of viral load in Crimean Congo hemorrhagic fever

Hasanoğlu

Güner

Çarhan

et al. 2017

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

show abstract

Investigating the effect of ribavirin treatment on genetic mutations in Crimean–Congo haemorrhagic fever virus (CCHFV) through next‐generation sequencing

D'Addiego

Elaldı

Wand³

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

Crimean-Congo haemorrhagic fever (CCHF) is the most widespread tick-borne viral haemorrhagic fever affecting humans, and yet a licensed drug against the virus (CCHFV) is still not available. While several studies have suggested the efficacy of ribavirin against CCHFV, current literature remains inconclusive. In this study, we have utilised next-generation sequencing to investigate the mutagenic effect of ribavirin on the CCHFV genome during clinical disease. Samples collected from CCHF patients receiving ribavirin treatment or supportive care only at Sivas

show abstract