Crustacean molt-inhibiting hormone: Structure, function, and cellular mode of action

Nakatsuji, Teruaki; Lee, Chi Ying; Watson, R. Douglas

doi:10.1016/j.cbpa.2008.10.012

Cited by 116 publications

(88 citation statements)

References 75 publications

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“…The YOs are controlled by inhibitory neuropeptides produced by the X-organ/sinus gland (XO/SG) complex located in the eyestalks of decapod crustaceans (reviewed by Chang and Mykles, 2011;Hopkins, 2012;Lachaise et al, 1993;Skinner, 1985;Webster et al, 2012). Molt-inhibiting hormone (MIH) and crustacean hyperglycemic hormone (CHH) inhibit ecdysteroidogenesis in the YO (reviewed by Chang and Mykles, 2011;Covi et al, 2012;Nakatsuji et al, 2009;Webster et al, 2012). MIH is expressed primarily in the XO/SG complex, but there are reports of MIH mRNA and peptide in extra-eyestalk nervous tissues (Lu et al, 2001;Stewart et al, 2013;Tiu and Chan, 2007;Zhu et al, 2011).…”

Section: Control Of Moltingmentioning

confidence: 99%

“…By contrast, CHH is expressed in a wide variety of tissues including the XO/SG complex (Webster et al, 2012). Both neuropeptides share similar highly conserved motifs (reviewed by Nakatsuji et al, 2009;Webster et al, 2012) and inhibit ecdysteroid synthesis via cGMP-dependent signaling pathways (reviewed by Covi et al, 2009;Mykles et al, 2010). CHH is a pleiotropic neuropeptide that regulates glucose utilization, molting, osmoregulation and metabolism (reviewed by Chung et al, 2010;Fanjul-Moles, 2006;Webster et al, 2012).…”

Section: Control Of Moltingmentioning

confidence: 99%

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Molt regulation in green and red color morphs of the crab,Carcinus maenas: gene expression of molt-inhibiting hormone signaling components

Abuhagr

Blindert

Nimitkul

et al. 2013

Journal of Experimental Biology

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There was an error published in J. Exp. Biol. 217, In Fig. 3, the letters and numbers indicating which means were significantly different are missing from panel A. The correct figure is printed below.We apologise to the authors and readers for this omission. ) characteristic of late premolt animals and animals did not molt by 90 days post-ESA. There was no effect of ESA or MLA on the expression of Cm-elongation factor 2 (EF2), Cm-NOS, the beta subunit of GC-I (Cm-GC-Iβ), a membrane receptor GC (Cm-GC-II) and a soluble NO-insensitive GC (Cm-GC-III) in green morphs. Red morphs were affected by prolonged ESA and MLA treatments, as indicated by large decreases in Cm-EF2, Cm-GC-II and Cm-GC-III mRNA levels. ESA accelerated the transition of green morphs to the red phenotype in intermolt animals. ESA delayed molting in premolt green morphs, whereas intact and MLA animals molted by 30 days post treatment. There were significant effects on YO gene expression in intact animals: Cm-GC-Iβ mRNA increased during premolt and Cm-GC-III mRNA decreased during premolt and increased during postmolt. Cm-MIH transcripts were detected in eyestalk ganglia, the brain and the thoracic ganglion from green intermolt animals, suggesing that MIH in the brain and thoracic ganglion prevents molt induction in green ESA animals.

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Section: Control Of Moltingmentioning

confidence: 99%

Section: Control Of Moltingmentioning

confidence: 99%

Molt regulation in green and red color morphs of the crab,Carcinus maenas: gene expression of molt-inhibiting hormone signaling components

Abuhagr

Blindert

Nimitkul

et al. 2013

Journal of Experimental Biology

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“…Heavy losses have been reported by the shrimp or aquaculture industries due to the outbreak of diseases. Gene structure of gonad inhibiting hormone (GIH) and moult inhibiting hormone (MIH) in case of certain marine shrimps has already been investigated [22][23][24]. This structure of the gene can be altered/edited by using CRISPRCas technology to eliminate the negative impact of these hormones on reproduction and growth processes.…”

Section: Gene Editing Technologymentioning

confidence: 99%

Gene editing (CRISPR-Cas) technology and fisheries sector

Ninawe¹,

Harke²

2017

Can J Biotech

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| P a g e AbstractConsidering the advantages of gene editing technologies, in recent years, emphasis has been given on three main techniques of gene editing i.e. zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the CRISPR/Cas9 RNA-guided endonuclease system. In all of these three technologies one thing is common i.e. the technology utilizes restriction enzymes to break down the double stranded DNA molecule at a targeted location with the help of another molecule of homologous binding protein or RNA, which is also called as a guide RNA molecule. This targeted breaking and repair of the DNA molecule as per our requirement is generally viewed as a great breakthrough in gene therapy methods. In fisheries sector, in order to promote aquaculture/mariculture activities, aquaculture industries are facing number of challenges, particularly in area of quality and demand of seed production, control of health and disease management, production of quality traits with phenotypically improved varieties, and strengthening of immune system. Several efforts are being made both at public and private sectors to develop scientific technologies to meet these challenges and substantial achievements have also been made. But still these challenges remained as major constraints in hampering the growth of this industry as per the demand and expectations. However, with the advent of now recently developed gene editing techniques, we may have to explore and evaluate the possibilities of applications of this technology as a long lasting solution in addressing at least some of the vital issues of the aquaculture industry particularly in those related to altering targeted gene structure in the species for positive impact.

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“…The X-organ-sinus-gland complex is a typical neuro-haemal organ located in the eye stalks, where a series of neuropeptides is produced, including some moult stimulating factors, which are shed into the haemolymph. The mode of action is apparently dependent on a reverse titre of MIH and ecdysone (Nakatsuji et al, 2009). Specific steroid levels control protein and lipid synthesis in relation to complex developmental and internal growth processes.…”

Section: Hormonal and Environmental Controlmentioning

confidence: 99%

“…Environmental cues modify the cycle via hormonal action, most possibly through variation of the MIH (Nakatsuji et al, 2009): crabs can halt ongoing moult processes when predators are present (Adelung, 1971) and low ecdysone levels are associated with diapause in copepods ( Johnson, 2003). The seasonal intensity of metabolic functions in Antarctic krill appear to be controlled by the photoperiod (Teschke et al, 2008) and a light signal may also trigger apolysis, to set off the next pre-moult phase (Seear et al, 2009).…”

Section: Hormonal and Environmental Controlmentioning

confidence: 99%