2023
DOI: 10.21203/rs.3.rs-3045457/v1
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Cryo-EM reveals variation in structural motifs within animal SARS-related coronavirus spike proteins

Abstract: SARS-CoV-2 is the third known coronavirus (CoV) that has crossed the animal-human barrier in the last two decades. However, little structural information exists related to the close genetic species within the SARS-related coronaviruses. Here, we present three novel SARS-related CoV spike protein structures solved by single particle cryo-electron microscopy analysis derived from bat (SL-CoV WIV1) and civet (CoV-SZ3, CoV-007) hosts. We report complex glycan trees that decorate the glycoproteins and density for w… Show more

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