Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

Jones, Luke O.; Williams, Leah; Boam, Tasmin; Kalmet, Martin; Oguike, Chidubem; Hatton, Fiona L.

doi:10.3762/bjoc.17.171

Cited by 35 publications

(23 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interest in porous biomedical materials continues to grow, as evidenced by the number of publications each year [2,[58][59][60]. Cellulose is a promising raw material for the production of cryogels.…”

Section: Concentrated Phosphoric Acidmentioning

confidence: 99%

“…Cryostructuring, including directional The chemical composition of the cryogel is probably the most important factor, since it determines the biocompatibility and degradability of the cryogel and, to some extent, affects the mechanical and thermal properties of the cryogel. The porosity and degree of crosslinking mainly affect the mechanical properties, while crosslinking itself affects the biocompatibility and degradability of the cryogel [2]. The pore size, wall thickness, and density affect the properties of cryogels [64], as thicker and higher-density walls improve their mechanical properties.…”

Section: Advantages Of Freeze-drying and Factors Affecting The Struct...mentioning

confidence: 99%

“…The degree of crosslinking in physically crosslinked cryogels is controlled by changing the number of freeze-thaw cycles [2]. Physical crosslinking does not use any organic solvents or toxic crosslinking agents, thereby eliminating any danger of residues in the final material and making this method very promising for biomedical applications [78].…”

Section: Type and Degree Of Crosslinkingmentioning

confidence: 99%

“…Cryogelation is one of the newly developed protocols for the production of polysaccharide materials for biomedical purposes [1]. Polysaccharide-based cryogels form a spongy super-macroporous structure during freeze-drying, making them highly promising materials for tissue engineering [2]. The production of polysaccharide cryogels has recently become a popular approach for the development of scaffolds [3], and these matrices are readily obtained by dissolving a polysaccharide (usually cellulose) in an appropriate solvent, followed by polymer regeneration from solution (solvent removal), freezing, and freeze-drying.…”

Section: Introductionmentioning

confidence: 99%

“…Other reviews consider cellulose cryogels to be sorbents [12,22]. Reviews that focus on the biomedical applications of cryogels contain information on many polysaccharide cryogels, with little [2,3,23,24] or no mention of cellulose cryogels [1]. A review of nanocellulose sponges and their biomedical applications has been published [25].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Cellulose Cryogels as Promising Materials for Biomedical Applications

Tyshkunova

Poshina

Skorik

2022

IJMS

View full text Add to dashboard Cite

The availability, biocompatibility, non-toxicity, and ease of chemical modification make cellulose a promising natural polymer for the production of biomedical materials. Cryogelation is a relatively new and straightforward technique for producing porous light and super-macroporous cellulose materials. The production stages include dissolution of cellulose in an appropriate solvent, regeneration (coagulation) from the solution, removal of the excessive solvent, and then freezing. Subsequent freeze-drying preserves the micro- and nanostructures of the material formed during the regeneration and freezing steps. Various factors can affect the structure and properties of cellulose cryogels, including the cellulose origin, the dissolution parameters, the solvent type, and the temperature and rate of freezing, as well as the inclusion of different fillers. Adjustment of these parameters can change the morphology and properties of cellulose cryogels to impart the desired characteristics. This review discusses the structure of cellulose and its properties as a biomaterial, the strategies for cellulose dissolution, and the factors affecting the structure and properties of the formed cryogels. We focus on the advantages of the freeze-drying process, highlighting recent studies on the production and application of cellulose cryogels in biomedicine and the main cryogel quality characteristics. Finally, conclusions and prospects are presented regarding the application of cellulose cryogels in wound healing, in the regeneration of various tissues (e.g., damaged cartilage, bone tissue, and nerves), and in controlled-release drug delivery.

show abstract

Section: Concentrated Phosphoric Acidmentioning

confidence: 99%

Section: Advantages Of Freeze-drying and Factors Affecting The Struct...mentioning

confidence: 99%

Section: Type and Degree Of Crosslinkingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cellulose Cryogels as Promising Materials for Biomedical Applications

Tyshkunova

Poshina

Skorik

2022

IJMS

View full text Add to dashboard Cite

show abstract

Phyllanthus emblica‐Loaded Cryogels for Improved Wound Care: Characterization and In Vitro Studies

Canatar,

Özdaş,

Baydemir Peşint

2024

Macro Materials & Eng

View full text Add to dashboard Cite

Wound dressings developed by combining plant extracts with polymers have made a great progress in wound care treatment. One plant with remarkable healing properties is Phyllanthus emblica Linn (P. emblica), which is described as having potent antioxidant, antimicrobial and anti‐inflammatory properties. The aim of this study is to evaluate the biocompatibility of P. emblica‐loaded polyvinyl alcohol/gelatin‐based cryogels (PVA/Gel/P.emblica) through cytotoxicity and proliferation tests in HaCaT cells and examine their potential in wound dressing applications. Accordingly, PVA/Gel/P.emblica cryogels are successfully synthesized and characterization studies and in vitro cell culture studies are performed. The swelling tests and Brunauer–Emmett–Teller analysis results show that swelling and surface area properties of cryogels increase with increasing P. emblica amounts. Morphological results display that the cryogels have a dense, interconnected pore morphology and a macroporous structure. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, trypan blue exclusion, and live–dead assay results reveal that P. emblica enhances cell proliferation, increases cell number, and improves cell viability. Based on the scanning electron microscope, immunofluorescence, and Giemsa staining images, it is observed that P. emblica promotes cell attachment, proliferation, and penetration. These findings confirm that PVA/Gel/P.emblica cryogels are suitable for use as wound dressing materials and can be developed with further studies.

show abstract

Sulfocontaining polyelectrolyte cryogels as metamaterials for energy storage devices

Iakobson,

Shevchenko,

Laishevkina

et al. 2024

Polymer International

View full text Add to dashboard Cite

A set of ionic cryogels based on the biocompatible zwitterionic polyelectrolyte N‐(3‐sulfopropyl)‐N‐(methacryloxyethyl)‐N,N‐dimethylammonium betaine and a second comonomer of a different nature (from the class of acrylates, acetates or sulfonic acids) is successfully synthesized. The variation of the nature of the comonomer used allows a material to be obtained with controlled pore sizes and hierarchical porosity as proved by SEM, optical microscopy and N2 adsorption–desorption experiments. The compositions of cryogels with good adhesive properties to the electrode, as well as effective ion exchange during an electrochemical reaction inside the cryogels, which is shown by reversible copper recharge processes after doping a cryogel with copper ions, are determined. Thus, cryogels that meet the primary requirements for a material for use as polymer electrolytes for batteries are synthesized and characterized. © 2024 Society of Chemical Industry.

show abstract

Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

Cited by 35 publications

References 121 publications

Cellulose Cryogels as Promising Materials for Biomedical Applications

Cellulose Cryogels as Promising Materials for Biomedical Applications

Phyllanthus emblica‐Loaded Cryogels for Improved Wound Care: Characterization and In Vitro Studies

Sulfocontaining polyelectrolyte cryogels as metamaterials for energy storage devices

Contact Info

Product

Resources

About