Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin–induced natural cycle

Fatemi, Human M.; Kyrou, D.; Bourgain, Claire; Abbeel, E. Van den; Griesinger, G.; Devroey, Paul

doi:10.1016/j.fertnstert.2009.11.036

Cited by 132 publications

(104 citation statements)

References 23 publications

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“…In this meta-analysis, tNC and mNC appear to be associated with similar clinical pregnancy and live birth rates. In this comparison, there are two RCTs [33,34], with opposing results. Fatemi et al [33] concluded that tNC is superior to mNC whereas Weissman et al [34] reported a similar pregnancy outcome.…”

Section: Discussionmentioning

confidence: 99%

“…A total of five studies, two RCTs [33,34] and three retrospective cohort studies [35][36][37], making a total of 2081 embryo transfer (ET) cycles, were included.…”

Section: Tnc Versus Mncmentioning

confidence: 99%

“…In two studies, no LPS was employed in both tNC and mNC arms [33,37]. However, LPS was administered to both tNC and mNC arms in another two studies [34,35].…”

Section: Tnc Versus Mncmentioning

confidence: 99%

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Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Yaralı́

Polat

Mümüşoğlu

et al. 2016

J Assist Reprod Genet

109

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Purpose The purpose of this study was to evaluate the best protocol to prepare endometrium for frozen embryo replacement (FER) cycles. Methods This study is a systematic review and meta-analysis. Following PubMed and OvidSP search, a total of 1166 studies published after 1990 were identified following removal of duplicates. Following exclusion of studies not matching our inclusion criteria, a total of 33 studies were analyzed. Primary outcome measure was live birth. The following protocols, including true natural cycle (tNC), modified natural cycle (mNC), artificial cycle (AC) with or without suppression, and mild ovarian stimulation (OS) with gonadotropin (Gn) or aromatase inhibitor (AI), were compared. Results No statistically significant difference for both clinical pregnancy and live birth was noted between tNC and mNC groups. When tNC and AC without suppression groups are compared, there was a statistically significant difference in clinical pregnancy rate in favor of tNC, whereas it failed to reach statistical significance for live birth. When tNC and AC with suppression groups are compared, there was a statistically significant difference in live birth rate favoring the latter. Similar pregnancy outcome was noted among mNC versus AC with or without suppression groups. Similarly, no difference in clinical pregnancy and live birth was noted when ACs with or without suppression groups are compared. Conclusions There is no consistent superiority of any endometrial preparation for FER. However, mNC has several advantages (being patient-friendly; yielding at least equivalent or better pregnancy rates when compared with tNC and AC with or without suppression; may not require LPS). Mild OS with Gn or AI may be promising.

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Section: Discussionmentioning

confidence: 99%

“…A total of five studies, two RCTs [33,34] and three retrospective cohort studies [35][36][37], making a total of 2081 embryo transfer (ET) cycles, were included.…”

Section: Tnc Versus Mncmentioning

confidence: 99%

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Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Yaralı́

Polat

Mümüşoğlu

et al. 2016

J Assist Reprod Genet

109

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“…But as cryopreservation techniques have been refined [8,9], more studies have reported improved outcomes after FET cycles when compared to fresh ET [7,14,15]. Traditionally, embryo cryopreservation was undertaken in patients with surplus embryos or patients with contraindications to transfer such as risk of OHSS or poor endometrial development and in some instances for fertility preservation.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, embryo cryopreservation was undertaken in patients with surplus embryos or patients with contraindications to transfer such as risk of OHSS or poor endometrial development and in some instances for fertility preservation. Recently, several groups have compared PR between embryos transferred during fresh-gonadotropin-stimulated-cycles versus FETs in a subsequent estrogenstimulated (synthetic) cycle [3,16] or under a natural cycle [14,17,18] with comparable conclusions. For example, a meta-analysis by Roque et al [7] included 3 trials accounting for 633 women.…”

Section: Discussionmentioning

confidence: 99%

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Rodriguez-Purata

Lee

Whitehouse

et al. 2016

J Assist Reprod Genet

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Purpose The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium. Material and Methods This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with trophectoderm biopsy from January 2011 to July 2015 were included. Patients were divided into three groups: "Fresh Only," "Frozen Embryo Transfer ('FET) Only," and "Fresh ET then FET." For "Fresh Only" group (n = 345), PGS results were received within 24 h. For "FET Only" group (n = 514), results were expected after 24 h, and embryos were cryopreserved after biopsy; only FET was performed in this group (no fresh transfer). For "FET with a previous fresh ET" (n = 139) group, patients underwent a fresh ET with a subsequent FET, in which the same cohort of embryos was utilized. The main outcome measures were pregnancy rate (PR), clinical PR, implantation rate (IR), LBR, and early pregnancy loss rate. Results IRs were statistically higher in the "FET Only" group when compared to the "Fresh Only" group (59.5 vs. 50.6 %, p < 0.01) and the "FET with a previous fresh ET" (59.5 vs. 50.6 %, p < 0.05). LBR was statistically significant in the "FET Only" group when compared to the "Fresh Only" group (57.6 vs. 46.5 %, p < 0.005) but not when compared to "FET with a previous fresh ET" group (57.6 vs. 47.7 %, p = 0.07). Conclusions This analysis suggests euploid embryos to be more likely to implant and achieve a LBR in a synthetic FET cycle than in a fresh cycle.

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Cycle regimens for frozen-thawed embryo transfer

Ghobara

Gelbaya

Ayeleke

2017

Cochrane Database of Systematic Reviews

267

222

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Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin–induced natural cycle

Cited by 132 publications

References 23 publications

Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Cycle regimens for frozen-thawed embryo transfer

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