Cryoprobe biopsy increases the diagnostic yield in endobronchial tumor lesions

Schümann, Christian; Hetzel, Juergen; Babiak, Anna; Merk, T; Wibmer, Thomas; Möller, Peter; Lepper, Philipp M.; Hetzel, M

doi:10.1016/j.jtcvs.2009.12.028

Cited by 106 publications

(93 citation statements)

References 10 publications

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“…Schumann et al [7] examined a total number of 296 patients with visible endoluminal tumor. The final included group consisted of 55 patients, where both cryobiopsy and forceps biopies were done in the same patient.…”

Section: Discussionmentioning

confidence: 99%

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Cryobiopsy versus Forceps Biopsy in Endobronchial Lesions, Diagnostic Yield and Safety

Ehab

El-Badrawy

Moawad

et al. 2017

Advances in Respiratory Medicine

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Introduction: This study aimed to evaluate the safety and diagnostic yield of cryobiopsy (CB) in comparison to forceps biopsy in endobronchial lesions. Material and methods:Patients with suspected endobronchial lesions were enrolled. Two forceps biopsies and one cryobiopsy were done in the same patient with randomized sequence. The largest diameter of the samples was measured in mm by electronic caliper. Diagnostic yield of each technique and postbronchoscopy bleeding were evaluated. Results: Samples obtained by CB was significantly larger than that of the forceps biopsy (5.9 ± 2.3 vs 2.5 ± 0.8, p = 0.001). Diagnostic yield of CB was significantly higher than forceps biopsy 74.5% versus 51.1% (p = 0.001). Mild and moderate bleeding grades were reported in both techniques with no significant difference (p = 0.063, p = 0.5), respectively. Severe bleeding was not recorded in both techniques. Conclusions: CB represents a safe and effective tool to obtain a larger tissue samples of a good quality with higher diagnostic yield in comparison to standard forceps samples. On the other hand, bleeding occurred more frequently after CB than forceps biopsy. However, without severe adverse effects.

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Section: Discussionmentioning

confidence: 99%

“…It is used www.journals.viamedica.pl primarily for debulking and cryoextraction of malignant airway stenosis [7,8]. With this technique, the sample is collected while still being frozen, with the tissue attached on the frozen tip of the probe.…”

Section: Introductionmentioning

confidence: 99%

Cryobiopsy versus Forceps Biopsy in Endobronchial Lesions, Diagnostic Yield and Safety

Ehab

El-Badrawy

Moawad

et al. 2017

Advances in Respiratory Medicine

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“…Endobronchial CB is safe and increases the diagnostic yield in comparison with conventional FB [11,30,31]. e overall superiority of CB is most likely due to the higher quality of the samples from their signi cantly larger biopsies regarding size and artifact-free tissue sections, which has been shown in previous studies [14,28,31,32]. e cryotherapy probe also facilitates sampling of target lesions positioned tangentially to the instrument, which are di cult than samples from exible forceps, especially in narrow airway.…”

Section: Discussionmentioning

confidence: 99%

Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study

Chen

Cheng

et al. 2017

Interventional Pulmonology

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Background. e aim of this study was thus to evaluate the feasibility and safety of taking biopsy specimens by cryoprobe from the parietal pleura during semirigid pleuroscope. Methods. In a single-center, observational, prospective study, patients with exudative pleural e usion (EPE) were evaluated with a semirigid pleuroscope between January 2015 and July 2017. Each patient underwent pleural biopsy using exible forceps and exible cryoprobe through pleuroscope following diagnostic thoracentesis and closed pleural biopsy (CPB). Results. A total of 92 patients (median age 64 years) were included in the study, most of whom were men (65.2%). Cytological cell block (CCB) and CPB made de nitive diagnoses in 32/92 (34.8%) and 25/92 (27.5%), respectively; exible forceps biopsy (FFB) and cryoprobe biopsy (CB) established de nitive diagnoses in 84/92 (91.3%) and 91/92 (98.9%), respectively. e sample obtained by CB (9.4 ± 4.9 mm) was signi cantly larger than the other two methods: FFB (4.2 ± 2.3 mm) or CPB (1.9 ± 1.0 mm) (P < 0.0001).e immunohistochemical (IHC) staining was more easily performed with CB (98.9%) compared to either FFB (87.0%) or CPB (13.0%).ere were no signi cant complications or procedure-related deaths. Conclusions. Based on these results, CB during semirigid pleuroscope has a high diagnostic yield, di erentiating EPE of unknown etiology with satisfactory e ectiveness and safety.

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“…28 In addition, cytological methods such as protected specimen brush, bronchial washing, or bronchoalveolar lavage tend to increase the diagnostic yield. Conventional mediastinoscopy is limited to paratracheal lymph nodes (2R, 2L, 4R, and 4L), pretracheal nodes (stations 1 and 3), and anterior subcarinal nodes (station 7).…”

Section: Biopsy and Stagingmentioning

confidence: 99%

Superior Vena Cava Syndrome in Thoracic Malignancies

et al. 2011

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The superior vena cava syndrome (SVCS) comprises various symptoms due to occlusion of the SVC, which can be easily obstructed by pathological conditions (eg, lung cancer, due to the low internal venous pressure within rigid structures of the thorax [trachea, right bronchus, aorta]). The resulting increased venous pressure in the upper body may cause edema of the head, neck, and upper extremities, often associated with cyanosis, plethora, and distended subcutaneous vessels. Despite the often striking clinical presentation, SVCS itself is usually not a life-threatening condition. Currently, randomized controlled trials on many clinically important aspects of SVCS are lacking. This review gives an interdisciplinary overview of the pathophysiology, etiology, clinical manifestations, diagnosis, and treatment of malignant SVCS.

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Cryoprobe biopsy increases the diagnostic yield in endobronchial tumor lesions

Abstract: Cryobiopsy is safe and increases the diagnostic yield in endobronchial tumor lesions. The method also is feasible under routine conditions.

Cited by 106 publications

References 10 publications

Cryobiopsy versus Forceps Biopsy in Endobronchial Lesions, Diagnostic Yield and Safety

Cryobiopsy versus Forceps Biopsy in Endobronchial Lesions, Diagnostic Yield and Safety

Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study

Superior Vena Cava Syndrome in Thoracic Malignancies

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