Cryosurgery: A simple tool to address oral lesions

Asrani, Sumit; Reddy, Praveen B; Dhirawani, Rajesh B; Jain, Sanchit; Pathak, Sanyog; Asati, Pranav

doi:10.4103/ccd.ccd_708_17

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…It is noteworthy that aggressive tendencies or malignant transformations of PGCG have never been reported in the current literature [14,15]. Nevertheless, in our case, the lesion was aggressive in nature with a rapid and high recurrence rate; hence, it is fundamental to control the disease progression by reducing the pathogen via a thorough decontamination of the affected region.…”

Section: Pgcg Excision With Surgical Lasers Vs Conventional Surgical ...mentioning

confidence: 61%

10,600 nm High Level-Laser Therapy Dosimetry in Management of Unresponsive Persistent Peripheral Giant Cell Granuloma to Standard Surgical Approach: A Case Report with 6-Month Follow-Up

Hanna,

Benedicenti

2023

JPM

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Peripheral giant cell granuloma (PGCG) is a non-neoplastic, tumour-like reactive lesion that exclusively involves the gingiva and/or the alveolar crest. The surgical approach with a scalpel has been the golden standard of treatment for PGCG, but the scientific literature reports a high rate of lesion recurrence. Hence, this unique case report aimed to evaluate the efficacy of λ 10,600 nm high-level laser therapy (HLLT) in eradicating persistent, aggressive, and recurrent PGCG that failed to respond to standard surgical treatment. A fit and healthy thirty-four-year-old Caucasian male presented with a two-month history of recurrent episodes of an oral mucosal lesion involving the buccal and lingual interdental papillae between the lower right second premolar (LR5) and lower right first molar (LR6), which was surgically excised with a scalpel three times previously. A λ 10,600 nm-induced HLLT was chosen as a treatment modality at a lower peak power of 1.62 W, measured with a power metre, emitted in gated emission mode (50% duty cycle), whereby the average output power reaching the target tissue was 0.81 W. The spot size was 0.8 mm. Ninety seconds was the total treatment duration, and the total energy density was 7934.78 J/cm2. Patient self-reporting outcomes revealed minimal to no post-operative complications. Initial healing was observed on the 4th day of the post-laser treatment, and a complete healing occurred at two-weeks post-operatively. The histological analysis revealed PGCG. This unique case report study demonstrated the efficacy of λ 10,600 nm-induced HLLT and its superiority to eradicate persistent aggressive PGCG over the standard surgical approach with minimal to no post-operative complications, accelerating wound healing beyond the physiological healing time associated with no evidence of PGCG recurrence at the six-month follow-up timepoint. Based on the significant findings of this unique study and the results of our previous clinical studies, we can confirm the validity and effectiveness of our standardised λ 10,600 nm laser dosimetry-induced HLLT and treatment protocol in achieving optimal outcomes. Randomised controlled clinical trials with large data comparing λ 10,600 nm with our dosimetry protocol to the standard surgical treatment modality at long follow-up timepoints are warranted.

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Section: Pgcg Excision With Surgical Lasers Vs Conventional Surgical ...mentioning

confidence: 61%

10,600 nm High Level-Laser Therapy Dosimetry in Management of Unresponsive Persistent Peripheral Giant Cell Granuloma to Standard Surgical Approach: A Case Report with 6-Month Follow-Up

Hanna,

Benedicenti

2023

JPM

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“…The lethal effect of thawing suggests that repeated cycles of freezing and thawing are potentially more destructive than single long-time freezing 18. Cryotherapy using a closed system has very few side effects including unpredictable rate of swelling, uncontrolled depth and area of freezing and high operator dependency 19…”

Section: Discussionmentioning

confidence: 99%

Cryosurgery of multiple haemangiomas of oral cavity

et al. 2022

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Haemangiomas of the oral cavity are common benign vascular tumours of infancy. Several treatment modalities are described for haemangiomas, including sclerotherapy, embolisation, laser surgery and cryotherapy. Cryotherapy is the application of varying extremes of low temperatures to destroy abnormal tissue. Since cryosurgery is effective, simple and easy to perform, it is used in the treatment of lesions in both medicine and dentistry. Cryosurgery provides many advantages such as easy operation, absence of intraoperative bleeding and low infection rate. In this case, the cryosurgical treatment of a young patient who suffered from multiple haemangiomas of the oral cavity that was refractory to medical treatment is presented.

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“…Liquid nitrogen cryosurgery in the management of oral mucosal lesions 1: The study with 30 patients was evaluated for the efficacy of cryosurgery in the management of oral mucosal lesions (mucocele, fibroma, leukoplakia, erythroplakia, and lichen planus). Time taken for healing, postoperative pain, secondary infection, and recurrence of lesion was calibrated.…”

mentioning

confidence: 99%

Cryogens in dentistry

Shamim¹

2019

Med Gas Res

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Cryosurgery: A simple tool to address oral lesions

Cited by 9 publications

References 13 publications

10,600 nm High Level-Laser Therapy Dosimetry in Management of Unresponsive Persistent Peripheral Giant Cell Granuloma to Standard Surgical Approach: A Case Report with 6-Month Follow-Up

10,600 nm High Level-Laser Therapy Dosimetry in Management of Unresponsive Persistent Peripheral Giant Cell Granuloma to Standard Surgical Approach: A Case Report with 6-Month Follow-Up

Cryosurgery of multiple haemangiomas of oral cavity

Cryogens in dentistry

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