Cryosurgery as primary treatment for localized prostate cancer

Lian, Huibo; Guo, Hongqian; Gan, Weidong; Li, Xiaogong; Xiang, Yan; Wang, Wei; Yang, Rong; Qu, Feng; Ji, Changwei

doi:10.1007/s11255-011-9952-7

Cited by 15 publications

(5 citation statements)

References 20 publications

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“…Lian et al addressed the preliminary results of 102 patients underwent primary cryoablation for clinically localized PCa from January 2006 to December 2009 in Nanjing Drum Tower Hospital. The early results of their study suggest that cryoablation offers a safe and effective alternative for the primary treatment of localized prostate cancer [ 24 ]. Recently, Zhou et al analysed the results of a study of 23 patients with metastatic BC under percutaneous cryosurgery.…”

Section: Discussionmentioning

confidence: 99%

Transperineal cryotherapy for unresectable muscle invasive bladder cancer: preliminary experience with 7 male patients

Zhang

et al. 2017

BMC Urol

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BackgroundRadical cystectomy (RC) with pelvic lymph node dissection (PLND) and urinary diversion (UD) is considered the standard treatment for muscle invasive bladder cancer (MIBC). In a part of patients, RC procedure is aborted due to unresectable disease, other followed treatment like systemic chemotherapy, radiotherapy or cryotherapy may be a better option. The aim of present study was to report the preliminary results of transperineal cryotherapy for unresectable muscle invasive bladder cancer.MethodsFrom January 2011 to August 2013, 7 male patients with pT4b unresectable bladder cancer underwent bilateral ureterocutaneostomy. Two performed a pelvic lymph node dissection (PLND). Then primary transperineal cryosurgery for preserved bladder at the guidance of transrectal ultrasound (TRUS) was performed. All patients underwent a dual freeze-thaw cycle using third-generation cryotechnology with ultrathin 17-gauge cryoneedles. Computer tomography (CT) and/or magnetic resonance image (MRI)were performed at 3 month intervals after cryosurgery to determine whether progression or recurrence occurred.ResultsAll cryosurgery was performed successfully, mean operation time was 76.43 ± 25.12 min (range 50-120 min), mean blood loss was 19.29 ± 15.92 ml (range 5-50 ml). Mean hospital stay was 3.86 ± 1.68 day (range 2-7 days). No operative related deaths occurred. Four patients dead due to the metastasis disease at the follow up time of 8, 15, 18 and 37 months, respectively. Six patients received postoperative therapy, of whom 5 patients were treated with combined chemoradiation, and the other one received chemotherapy alone. The progression free survival (PFS) of the 7 patients was 22.00 ± 14.61 months (range 3-40 months). The one, two and three year overall survival (OS) was 85.7%, 57.1% and 42.9%, respectively.ConclusionOur results suggest that cryosurgery combination with chemoradiotherapy provide a safe and effective alternative method for unresectable pT4b bladder cancer. Longer follow-up is necessary to determine the sustained efficacy.

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Section: Discussionmentioning

confidence: 99%

Transperineal cryotherapy for unresectable muscle invasive bladder cancer: preliminary experience with 7 male patients

Zhang

et al. 2017

BMC Urol

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“…This method stems from similar minimally invasive ablation techniques pioneered by general surgeons. 19,35,40,68 Stereotactic laser ablation produces high temperatures that lead to tissue coagulation, necrosis, and cellular apoptosis. [2][3][4]7,32,60,73 Research in animals has shown that ablation produces a histologically proven immediate disruption of the blood-brain barrier (BBB) and subsequent neovascularization, which can be observed as enhancement on MRI sequences.…”

Section: Stereotactic Littmentioning

confidence: 99%

Stereotactic laser ablation of high-grade gliomas

Hawasli¹,

Kim

Dunn

et al. 2014

FOC

116

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Evolving research has demonstrated that surgical cytoreduction of a high-grade glial neoplasm is an important factor in improving the prognosis of these difficult tumors. Recent advances in intraoperative imaging have spurred the use of stereotactic laser ablation (laser interstitial thermal therapy [LITT]) for intracranial lesions. Among other targets, laser ablation has been used in the focal treatment of high-grade gliomas (HGGs). The revived application of laser ablation for gliomas parallels major advancements in intraoperative adjuvants and groundbreaking molecular advances in neuro-oncology. The authors review the research on stereotactic LITT for the treatment of HGGs and provide a potential management algorithm for HGGs that incorporates LITT in clinical practice.

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“…Repeating the freeze-thaw cycle leads to remarkable cell killing due to recrystallisation, cellular swelling and bursting [30]. Some authors have reported that they use this third-generation prostate cryotherapy as the primary treatment for low-risk and localised prostate cancers and achieve satisfactory early clinical outcomes [31]. Nerve-sparing cryotherapy is expected to decrease the high erectile dysfunction (ED) rates, while use of a urethral warming device can protect the urethra from damage due to over-freezing [32].…”

Section: Advances In Imaging-guided Interventions Of Prostate Cancersmentioning

confidence: 99%

Recent advances in imaging-guided interventions for prostate cancers

Wu¹,

Zhang²,

Chen³

et al. 2014

Cancer Letters

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The numbers of patients diagnosed with prostate cancers is increasing due to the widespread application of prostate-specific antigen screening and subsequent prostate biopsies. The methods of systemic administration of therapeutics are not target-specific and thus cannot efficiently destroy prostate tumour cells while simultaneously sparing the surrounding normal tissues and organs. Recent advances in imaging-guided minimally invasive therapeutic techniques offer considerable potential for the effective management of prostate cancers. An objective understanding of the feasibility, effectiveness, morbidity, and deficiencies of these interventional techniques is essential for both clinical practice and scientific progress. This review presents the recent advances in imaging-guided interventional techniques for the diagnosis and treatment of prostate cancers.

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Cryosurgery as primary treatment for localized prostate cancer

Abstract: Early results suggest that cryotherapy offers a safe and effective alternative for the primary treatment of localized prostate cancer. Additional studies with longer follow-up are necessary to determine the sustained efficacy of this procedure.

Cited by 15 publications

References 20 publications

Transperineal cryotherapy for unresectable muscle invasive bladder cancer: preliminary experience with 7 male patients

Transperineal cryotherapy for unresectable muscle invasive bladder cancer: preliminary experience with 7 male patients

Stereotactic laser ablation of high-grade gliomas

Recent advances in imaging-guided interventions for prostate cancers

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