Cryotherapy for low rectal and anal cancer: recommendation and indications

Jiang, Xuejun; Ji, Zujin; Lei, Xinyi; He, Yue; Yuan, Fangjun

doi:10.3389/fonc.2023.984145

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…In addition to the efficacy of CA alone, the use of adjuvants to increase the lethality of freezing has been well documented in many cancer types, including prostate [ 28 , 29 , 30 , 31 ], kidney [ 32 , 33 , 34 ], breast [ 35 , 36 , 37 ], lung [ 38 , 39 , 40 , 41 ], among others [ 17 , 19 , 42 , 43 , 44 ]. Adjuvants can include traditional chemotherapeutic agents (drugs), other thermal ablation strategies, small molecules or immunotherapies, to name a few [ 17 , 38 , 42 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Lung Cancer Cell Response to Cryoablation and Adjunctive Gemcitabine-Based Cryo-Chemotherapy Using the A549 Cell Line

Santucci,

Snyder,

Van Buskirk

et al. 2024

Biomedicines

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Due to the rising annual incidence of lung cancer (LC), new treatment strategies are needed. While various options exist, many, if not all, remain suboptimal. Several studies have shown cryoablation to be a promising approach. Yet, a lack of basic information pertaining to LC response to freezing and requirement for percutaneous access has limited clinical use. In this study, we investigated the A549 lung carcinoma cell line response to freezing. The data show that a single 5 min freeze to −15 °C did not affect cell viability, whereas −20 °C and −25 °C result in a significant reduction in viability 1 day post freeze to <10%. These populations, however, were able to recover in culture. Application of a repeat (double) freeze resulted in complete cell death at −25 °C. Studies investigating the impact of adjunctive gemcitabine (75 nM) pretreatment in combination with freezing were then conducted. Exposure to gemcitabine alone resulted in minimal cell death. The combination of gemcitabine pretreatment and a −20 °C single freeze as well as combination treatment with a −15 °C repeat freeze both resulted in complete cell death. This suggests that gemcitabine pretreatment may be synergistically effective when combined with freezing. Studies into the modes of cell death associated with the increased cell death revealed the increased involvement of necroptosis in combination treatment. In summary, these results suggest that repeat freezing to −20 °C to −25 °C results in a high degree of LC destruction. Further, the data suggest that the combination of gemcitabine pretreatment and freezing resulted in a shift of the minimum lethal temperature for LC from −25 °C to −15 °C. These findings, in combination with previous reports, suggest that cryoablation alone or in combination with chemotherapy may provide an improved path for the treatment of LC.

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Section: Introductionmentioning

confidence: 99%

Investigation of Lung Cancer Cell Response to Cryoablation and Adjunctive Gemcitabine-Based Cryo-Chemotherapy Using the A549 Cell Line

Santucci,

Snyder,

Van Buskirk

et al. 2024

Biomedicines

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Knowledge and Attitude Towards Traditional, Complementary and Alternative Medicine on Colorectal Cancer Among Northern Malaysians

Ashruf,

Seng,

Ismail

et al. 2024

Journal of Pharmacology and Pharmacotherapeutics

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Background: Colorectal cancer (CRC) is the third most common cancer worldwide causing approximately 10% of all cancer cases and is the second most frequent disease which is one of the leading causes of cancer-related fatalities. Traditional, complementary and alternative medicine (TCAM) refers to a broad range of health practices, therapies and products typically not part of the ‘conventional medicine’ system, and its use is substantial among the general population. The knowledge and awareness levels about TCAM and the use of allopathic medications for the treatment of cancer are varied among individuals. The studies were conducted on the knowledge and awareness of the public on cancer, however, no studies specifically addressing the knowledge, attitude and practice of TCAM about CRC were found in Malaysia. Purpose: The present study aims to assess the knowledge of CRC and attitude towards TCAM in terms of CRC among a representative sample in Malaysia and identifying the sources of information about CRC and gauging the satisfaction levels with the services of a traditional medicine practitioner. Methods: A validated self-administered questionnaire and educational brochure were utilized for this study. Convenience sampling was employed to recruit respondents ( n = 548) from Kedah and Penang. The calculated sample size was 500. SPSS v25 was used to analyse the data. Results: The demographic data were statistically significant ( p < .05), the inference could be the sampling technique. Of the 548 respondents, 50.7% ( n = 278) of them were CRC survivors. About 96.2% ( n = 527) understood that CRC occurs in the colon or rectum. The majority were aware that rectal bleeding (75.4%) and blood in the stool (80.7%), are CRC’s signs and symptoms, while only 24.6% identified weakness and fatigue as CRC’s signs and symptoms. The respondents had poor knowledge scores (13.72 out of 31.00) as per Bloom’s cut-off scoring system. In terms of attitude towards TCAM, the majority had a ‘neutral’ (neither agree nor disagree) opinion for all the statements, meaning that the respondents surveyed were very undecided (neither positive nor negative opinion). Conclusion: Knowledge of CRC was poor for the cohort, while the attitude towards TCAMs was neutral. The average ‘neutral’ response in the attitude domain could indicate that the respondents had minimal understanding of TCAM about CRC. Further, longitudinal studies can be conducted to better gauge the public’s knowledge, attitude and practice (KAP) towards CRC and TCAM. This highlights the importance of educational interventions which may help to improve the public’s KAP towards CRC and TCAM.

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Cryotherapy for low rectal and anal cancer: recommendation and indications

Cited by 2 publications

References 17 publications

Investigation of Lung Cancer Cell Response to Cryoablation and Adjunctive Gemcitabine-Based Cryo-Chemotherapy Using the A549 Cell Line

Investigation of Lung Cancer Cell Response to Cryoablation and Adjunctive Gemcitabine-Based Cryo-Chemotherapy Using the A549 Cell Line

Knowledge and Attitude Towards Traditional, Complementary and Alternative Medicine on Colorectal Cancer Among Northern Malaysians

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