Cryotherapy versus Laser Does Not Influence Anatomic Success after Vitrectomy for Primary Rhegmatogenous Retinal Detachment Repair

Galvin, Justin; Earnest, Arul; Egwunye, Jacob; Essex, Rohan W; Ahern, Susannah; Allen, Philip A.; Chen, Fred K.; Clarke, Ben; Lake, Stuart; Simunovic, Matthew P.; Symonds, Andrew C.; Yap, Joel; Gilhotra, Jolly; Chan, Weng Onn; Fung, Adrian T.

doi:10.1016/j.oret.2022.05.025

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…The postoperative visual outcomes are influenced by various factors, and eventual visual acuity might have further improved over time [16] . Our results align with a large study involving 2413 patients, which reported a visual acuity change of -0.50 logMAR at 3mo postoperatively [17] . Elevated IOP is a common postoperative complication, influenced by various factors including oil tamponade, history of glaucoma or ocular hypertension, and topical corticosteroids as routine postoperative medications following surgery [18][19] .…”

Section: Perfluoro-n-octane In Retinal Detachmentsupporting

confidence: 91%

Pars plana vitrectomy for retinal detachment using perfluoro-n-octane as intraoperative tamponade: a multicenter, randomized, non-inferiority trial

Shi,

Fan,

Liu

et al. 2024

Int J Ophthalmol

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AIM: To evaluate the efficacy and safety of perfluoro-n-octane (PFO) for ophthalmic surgery versus F-Octane as an intraoperative tamponade in pars plana vitrectomy (PPV) in management of retinal detachment. METHODS: This multicenter, prospective, randomized, double-masked, parallel-controlled, non-inferiority trial was conducted in three ophthalmology clinical centers in China. Patients with retinal detachment, who were eligible for PPV were consecutively enrolled. Participants were assigned to PFO for ophthalmic surgery or F-Octane for intraocular tamponade in a 1:1 ratio. Best-corrected visual acuity (BCVA), intraocular pressure (IOP) measurement, and dilated fundus examination were performed preoperatively and at 1, 7±1, 28±3d postoperatively. The primary outcome was complete retinal reattachment rate at postoperative day one. The non-inferiority margin was set at 9.8%. The secondary outcomes included intraoperative retinal reattachment rate, and mean changes in IOP and BCVA from baseline to 1, 7±1, 28±3d postoperatively, respectively. Safety analyses were presented for all randomly assigned participates in this study. RESULTS: Totally 124 eligible patients completed the study between Mar. 14, 2016 and Jun. 7, 2017. Sixty of them were randomly assigned to the PFO for ophthalmic surgery group, and 64 were assigned to the F-Octane group. Baseline characteristics were comparable between the two groups. Both groups achieved 100% retinal reattachment at postoperative day one (difference 0, 95%CI: -6.21% to 5.75%, P=1). The pre-defined noninferiority criterion was met. No significant difference was observed in intraoperative retinal reattachment rate (difference 1.77%, P=0.61), mean changes in IOP (difference 0.36, -0.09, 2.22 mm Hg at 1, 7±1, 28±3d postoperatively, with all P&#x003E;0.05) and BCVA (difference 0.04, -0.02, 0.06 logMAR at 1, 7±1, 28±3d postoperatively, all P&#x003E;0.05) between the two groups. No apparent adverse events related to the utilization of PFO were reported. CONCLUSION: In patients with retinal detachment undergoing PPV, PFO for ophthalmic surgery is non-inferior to F-Octane as an intraocular tamponade, and both are safe and well-tolerated.

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