Cryotherapy versus topical nitric‐zinc complex solution for the treatment of plantar warts: A randomized controlled trial

Abstract

BackgroundCryotherapy is commonly regarded as the primary treatment method for plantar warts. A new medical device called Nitric‐zinc complex solution (NZCS) has also emerged as a potential alternative for wart treatment.ObjectiveThe main aim of this study was to analyze and compare the effectiveness of cryotherapy using liquid nitrogen and NZCS in treating plantar warts.MethodsWe conducted a randomized and controlled clinical trial involving patients with plantar warts. A total of 62 patients were enrolled in the study and monitored for 12 weeks or until their warts were completely resolved. The patients received either cryotherapy or NZCS, with a maximum of six treatment applications.ResultsThe cure rate was 65.5% in the group treated with cryotherapy and 56.6% in the group treated with NZCS. The average number of treatment applications required for curing warts was significantly lower in the cured group (3.28 ± 1.63) than in the group with unresolved warts (5.5 ± 1.27) (p<0.01). Moreover, the average number of applications was lower in the cryotherapy group (3.6 ± 1.8) than in the NZCS group (4.8 ± 1.8) (p<0.01).ConclusionsBased on the findings, NZCS could be considered a favorable first‐line treatment option for plantar warts.This article is protected by copyright. All rights reserved.

Efficient Topical Treatment of Canine Nodular Sebaceous Hyperplasia with a Nitric Acid and Zinc Complex Solution

“…The solution with a nitric zinc complex is of great value when dealing with difficult palmoplantar and anogenital warts in human medicine [31][32][33][34][35][36]. This study shows that it can also be of use in veterinary medicine.…”

“…In human medicine, nitric zinc complex solution (Verrutop ® ) has been compared to cryotherapy for treating anogenital warts, with a good effect, better tolerability, and a lower recurrence rate [34]. In plantar warts, other studies show similar results as treatment with cryotherapy [35].…”

“…In human medicine, a nitric zinc complex solution containing nitric acid, zinc, copper, and organic acids (acetic acid, oxalic acid, and lactic acid), with the trade name Verrutop ® , (manufacturer ISDIN, Barcelona, Spain), is used to treat difficult palmoplantar and small anogenital warts propagated by the human papilloma virus [31][32][33][34][35]. Upon application, the proteins are denaturized by nitric acid, and there is mummification of the tissue.…”