Cryptococcal Myositis and Vasculitis: An Unusual Necrotizing Soft Tissue Infection

Gave, Asaf; Torres, Richard; Kaplan, Lewis J.

doi:10.1089/sur.2004.5.309

Cited by 20 publications

(12 citation statements)

References 12 publications

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“…Cryptococcus neoformans infection may rarely present with infectious myositis (78,87,210). Most infections with this organism are asymptomatic; however, after the inhalation of the fungus, pulmonary, skin, or central nervous system (CNS) disease may occur.…”

Section: Cryptococcus Neoformansmentioning

confidence: 99%

“…Most cases occur among immunosuppressed persons; a review of the literature showed that cases have occurred in transplant recipients and patients with leukemia/lymphoma, AIDS, and hepatitis C viral infection (17,78,87,102,116,165,210). Patients often present with lower extremity pain and swelling.…”

Section: Cryptococcus Neoformansmentioning

confidence: 99%

“…Other sites of myositis have included the paraspinal muscles (210). Some cases have involved cellulitis and necrotizing fasciitis in addition to myositis (87). Muscle biopsy demonstrates the presence of the fungus; histopathology may reveal the absence of inflammation but the presence of intracytoplasmic cryptococcal organisms.…”

Section: Cryptococcus Neoformansmentioning

confidence: 99%

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Bacterial, Fungal, Parasitic, and Viral Myositis

2008

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SUMMARY Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection. For example, inciting events, including trauma, surgery, or the presence of foreign bodies or devitalized tissue, are often present in cases of bacterial myositis. Bacterial causes are categorized by clinical presentation, anatomic location, and causative organisms into the categories of pyomyositis, psoas abscess, Staphylococcus aureus myositis, group A streptococcal necrotizing myositis, group B streptococcal myositis, clostridial gas gangrene, and nonclostridial myositis. Fungal myositis is rare and usually occurs among immunocompromised hosts. Parasitic myositis is most commonly a result of trichinosis or cystericercosis, but other protozoa or helminths may be involved. A parasitic cause of myositis is suggested by the travel history and presence of eosinophilia. Viruses may cause diffuse muscle involvement with clinical manifestations, such as benign acute myositis (most commonly due to influenza virus), pleurodynia (coxsackievirus B), acute rhabdomyolysis, or an immune-mediated polymyositis. The diagnosis of myositis is suggested by the clinical picture and radiologic imaging, and the etiologic agent is confirmed by microbiologic or serologic testing. Therapy is based on the clinical presentation and the underlying pathogen.

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Section: Cryptococcus Neoformansmentioning

confidence: 99%

Section: Cryptococcus Neoformansmentioning

confidence: 99%

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Bacterial, Fungal, Parasitic, and Viral Myositis

2008

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“…Cryptococcal soft-tissue infection serves as a marker of disseminated cryptococcosis [13]. In our case, cryptococcal myositis developed in a patient with DM, and disseminated pulmonary infiltration was proven pathologically.…”

Section: Discussionmentioning

confidence: 56%

Myositis due toCryptococcus neoformansin a Diabetic Patient

Heo

Bae

Park

et al. 2009

Korean J Clin Microbiol

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We report a rare case of cryptococcal myositis with dissemination to lung in a 66-year-old diabetic woman who had no apparent risk factors for cryptococcal disease. She visited the hospital with a continuous pain in the right thigh and fever despite of treatment with antibiotics. She developed a localized lung infiltration. Crytococcus neoformans was isolated from the abscess of the right thigh and confirmed by molecular identification with DNA sequence analysis.Biopsy of the involved lung showed numerous budding yeasts consistent with Cryptocococcus species. The patient was successfully treated with surgical drainage and systemic antifungal agents.

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“…32 Despite treatment with anti-fungal therapy, the clinical course may be deleterious with evolution to necrotizing fasciitis. Surgical debridement may be necessary, 33 although it may lead to systemic involvement, as suggested in the present patient report. Overall mortality of cryptococcal cellulitis is high.…”

Section: Discussionmentioning

confidence: 78%