Cryptococcosis caused by cryptococcus gattii

Xue, Xinying; Deng, Hui; Zhao, Longting; Zang, Xuelei; Asuquo, Idorenyin Polycarp; Meng, Minghui; Ma, Xidong; Chong, Qin; Meng, Yan; Wu, Chongchong; Gao, Jie; Pan, Lei

doi:10.1097/md.0000000000023213

Cited by 6 publications

(1 citation statement)

References 55 publications

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“…C. gattii is an encapsulated yeast that has traditionally been found in tropical and subtropical regions. Outbreaks have been recorded in temperate regions such as the Pacific Northwest of the United States, [5,6] but there have been few reported cases of C. gattii in China. [7] C. neoformans is found worldwide.…”

Section: Discussionmentioning

confidence: 99%

Disseminated cryptococcosis mimicking malignant lymphoma on 18F-FDG PET/CT: A case report

Zhang

Tian

et al. 2022

Medicine

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Rationale: Disseminated cryptococcosis is extremely rare and is easily misdiagnosed as a malignant lymphoma. 18 F-Fluorodeoxyglucose Positron Emission Tomography (PET)/ computed tomography (CT) may be useful to assess the involvement of disseminated cryptococcosis and to evaluate residual disease after treatment.Patient Concerns: A 21-years-old man presented with fever and cough for a month, with multiple red nodules scattered on the skin. 18 F-Fluorodeoxyglucose PET/CT revealed multiple hypermetabolic lymph nodes in the upper and lower parts of the diaphragmatic region and hypermetabolic nodules in the skin. According to the PET/CT results, malignant lymphoma was considered a possibility, especially T-cell lymphoma involving the skin.Diagnosis: Cryptococcosis was diagnosed using inguinal lymph node biopsy and blood culture. Interventions:The patient received two months of amphotericin B, fluconazole, and half a month of meropenem.Outcomes: The patient's body temperature returned to normal and the red nodules on the skin disappeared. Most of the hypermetabolic enlarged lymph nodes disappeared, which was confirmed by reexamination with PET/CT.Lessons: Disseminated cryptococcosis is easily misdiagnosed as malignant lymphoma, especially when the lymph nodes are more involved. When multiple hypermetabolic enlarged lymph nodes appear on PET/CT, except for lymphoma, specific infections should also be considered.

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Section: Discussionmentioning

confidence: 99%

Disseminated cryptococcosis mimicking malignant lymphoma on 18F-FDG PET/CT: A case report

Zhang

Tian

et al. 2022

Medicine

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Deep learning‐enhanced microwell array biochip for rapid and precise quantification of Cryptococcus subtypes

Tong,

Zeng,

et al. 2024

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Cryptococcus is a family of strongly infectious pathogens that results in a wide variety of symptoms, particularly threatening the patients undergoing the immune‐deficiency or medical treatment. Rapidly identifying Cryptococcus subtypes and accurately quantifying their contents remain urgent needs for infection control and timely therapy. However, traditional detection techniques heavily rely on expensive, specialized instruments, significantly compromising their applicability for large‐scale population screening. In this work, we report a portable microwell array chip platform integrated with a deep learning‐based image recognition program, which enables rapid, precise quantification of the specific subtypes of Cryptococcus. The platform features four zones of microwell arrays preloaded with the subtype‐targeted CRISPR–Cas12a system that avoid dependence on slow, instrumental‐mediated target amplification, achieving rapid (10 min), high specificity for identifying the sequence of Cryptococcus. The deep learning‐based image recognition program utilizing segment anything model (SAM) significantly enhances automation and accuracy in identifying target concentrations, which eventually achieves ultra‐low limit of detection (0.5 pM) by personal smartphones. This platform can be further customized to adapt to various scenarios in clinical settings.

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