Cryptococcus neoformans in Association with Dermatophagoides pteronyssinus has Pro- (IL-6/STAT3 Overproduction) and Anti-inflammatory (CCL2/ERK1/2 Downregulation) Effects on Human Bronchial Epithelial Cells

Souza, Henrique Ismarsi de; Pereira, Aline Beatriz Mahler; Oliveira, Jhony Robison de; Silva, Paulo Roberto da; Teixeira, David Nascimento Silva; Silva‐Vergara, Mario León; Rogério, Alexandre de Paula

doi:10.1007/s10753-021-01619-4

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“…In the setting of Aspergillus infection, Dectin-1 and CR3 mediated release of IL-8 and MCP-1 through induction of NFκB [ 127 ]. The pro-inflammatory signal transducer and activator of transcription 3 (STAT3)-mediated IL-6 stimulation and anti-inflammatory response (e.g., chemokines C-C motif chemokine ligand 2 [CCL2]/extracellular signal regulated kinase ½ [ERK1/2] and IL-10) have been demonstrated in cryptococcal infections in vitro in combination with either cigarette smoke or Dermatophagoides pteronyssinus (a trigger for allergic asthma) [ 117 , 128 ]. While many of these studies provide a window into the human lung, they primarily utilize immortalized and oncologic cell lines and need to be validated in primary ALI systems.…”

Section: The Human Airway Epithelium Is a Key Player In The Host-fung...mentioning

confidence: 99%

Human Airway Epithelium Responses to Invasive Fungal Infections: A Critical Partner in Innate Immunity

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et al. 2022

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The lung epithelial lining serves as the primary barrier to inhaled environmental toxins, allergens, and invading pathogens. Pulmonary fungal infections are devastating and carry high mortality rates, particularly in those with compromised immune systems. While opportunistic fungi infect primarily immunocompromised individuals, endemic fungi cause disease in immune competent and compromised individuals. Unfortunately, in the case of inhaled fungal pathogens, the airway epithelial host response is vastly understudied. Furthering our lack of understanding, very few studies utilize primary human models displaying pseudostratified layers of various epithelial cell types at air-liquid interface. In this review, we focus on the diversity of the human airway epithelium and discuss the advantages and disadvantages of oncological cell lines, immortalized epithelial cells, and primary epithelial cell models. Additionally, the responses by human respiratory epithelial cells to invading fungal pathogens will be explored. Future investigations leveraging current human in vitro model systems will enable identification of the critical pathways that will inform the development of novel vaccines and therapeutics for pulmonary fungal infections.

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Section: The Human Airway Epithelium Is a Key Player In The Host-fung...mentioning

confidence: 99%

Human Airway Epithelium Responses to Invasive Fungal Infections: A Critical Partner in Innate Immunity

Crossen

Ward

Reedy

et al. 2022

JoF

View full text Add to dashboard Cite

show abstract

Cryptococcus neoformans in Association with Dermatophagoides pteronyssinus has Pro- (IL-6/STAT3 Overproduction) and Anti-inflammatory (CCL2/ERK1/2 Downregulation) Effects on Human Bronchial Epithelial Cells

Cited by 1 publication

References 74 publications

Human Airway Epithelium Responses to Invasive Fungal Infections: A Critical Partner in Innate Immunity

Human Airway Epithelium Responses to Invasive Fungal Infections: A Critical Partner in Innate Immunity

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