Crystal regeneration – a unique growth phenomenon observed in organic crystals post breakage

Bade, Isha; Verma, Vivek; Rosbottom, Ian; Heng, Jerry Y. Y.

doi:10.1039/d2mh01180h

Cited by 4 publications

(1 citation statement)

References 34 publications

(50 reference statements)

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“…When studying the re-growth of crystals after fracture, Bade et al [27] used the BFDH model to predict the morphology of the model compound, paracetamol, under equilibrium conditions. The modeling result was consistent with the crystal morphology obtained by the slow evaporation of ethanol under experimental conditions.…”

Section: Bfdh Modelmentioning

confidence: 99%

Crystal Morphology Prediction Models and Regulating Methods

Gao,

Song,

Yang

et al. 2024

Crystals

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Growing high-quality crystals with ideal properties is of great importance. The morphology of crystal is one key factor reflecting product quality, as it can affect the performance of products and downstream operations. In this work, the current state of crystal morphology modification is reviewed from different perspectives. First, the most widely used crystal growth models are discussed. Then, a variety of crystal morphology control methods, which include adjustment of crystallization operation parameters, addition of foreign molecules, change of different solvents, membrane assistance, the addition of external physical fields and the use of ball milling are summarized. As for applications, the control of crystal morphology has application potential in pharmaceutical and material fields, for example, energetic materials and semiconductor materials. Finally, the future development direction of crystal morphology regulation is discussed.

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Section: Bfdh Modelmentioning

confidence: 99%

Crystal Morphology Prediction Models and Regulating Methods

Gao,

Song,

Yang

et al. 2024

Crystals

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Uncovering crystal growth and regeneration mechanism to control crystal morphology: The case study of aceclofenac

Jiang,

Chen,

Zhou

et al. 2024

Separation and Purification Technology

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Growth of broken crystals tracked in 4D using X-ray computed tomography and its influence on impurity incorporation

Schiele,

Haider,

Briesen

2024

Sci Rep

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Crystallization is a commonly used unit operation for separation and purification. During processing, crystals may break due to mechanical stress, e.g., intentionally by milling or unintentionally through collision with stirrers. This study investigates the growth of broken crystals in three dimensions using X-ray micro-computed tomography. The results show that damaged regions of crystals grow faster than faceted regions, and crystals become faceted through growth. Initially, this happens on a microscale, producing faceted but concave regions on the crystal surface. Eventually, crystals become convex. Shape-healing through growth incorporates inclusions in the crystals. These findings have important implications for designing and optimizing crystallization processes in the pharmaceutical, food, and chemical industries, as purity is often a critical quality criterion adversely affected by inclusions. In addition, the kinetics in crystallization processes are likely to be strongly affected by the growth of non-faceted and concave crystals.

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Crystal regeneration – a unique growth phenomenon observed in organic crystals post breakage

Abstract: Crystal regeneration has been observed in macroscopic paracetamol crystals post breakage along their cleavage plane. High resolution imaging confirmed regeneration rates to be 3-fold faster than growth prior to breakage....

Cited by 4 publications

References 34 publications

Crystal Morphology Prediction Models and Regulating Methods

Crystal Morphology Prediction Models and Regulating Methods

Uncovering crystal growth and regeneration mechanism to control crystal morphology: The case study of aceclofenac

Growth of broken crystals tracked in 4D using X-ray computed tomography and its influence on impurity incorporation

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