Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2

Abstract

The crystal structure of a transplatin-derived complex, trans-[Pt(NH 3 ) 2 (dmtu) 2 ]Cl 2 (dmtu = N,N ' -dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH 3 ) 2 (dmtu) 2 ] 2? cation and two chloride ions. In trans-[Pt(NH 3 ) 2 (dmtu) 2 ] 2? , the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1 H and 13 C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract