Crystal structure, antibacterial activity and nanoparticles of Cd(II) complex derived from dithiophosphonate ligand

Banaei, Alireza; Saadat, Afshin; McArdle, Patrick; Goli, Mina Mohammad

doi:10.1080/10426507.2018.1424158

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…Investigations are also underway to design molecular complexes of radioactive transition metal cations to introduce into the human body for medical imaging (19)(20)(21). Some of tin DTPOA complexes are effective in chemotherapy (22) while some cadmium DTPOA complexes show antibacterial effect (23).…”

Section: Dithiophosphatementioning

confidence: 99%

New Homodinuclear Alkyl and Aryl Dithiophosphonato Cd(II) and Hg(II) complexes: Syntheses and Characterizations

Sağlam¹,

Bulat

Acar

et al. 2020

Journal of the Turkish Chemical Society Section A: Chemistry

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New Cd(II) and Hg(II) complexes of five previously known dithiophosphonic acids ((p-MeO-C6H4)PS(SH)(OR), HL n , (n= 1-5); R= 3-pentyl-, HL 1 ; R=1-phenyl-1-propyl-, HL 2 ; R= 4-tertbutylbenzyl-, HL 3 ; R= diphenylmethyl-, HL 4 ; R= 4-tert-butylcyclohexyl-, HL 5 ) were prepared and characterized. To do this, the dithiophosphonic acids involved were treated with stoichiometric amount of the corresponding metal salts in methyl alcohol. The complexes came of as powdery crystals and were recrystallized from chloroform. The pure complexes were characterized by using elemental analyses as well as mass-(ESI), FTIR-, Raman-, NMR-( 1 H, 13 C, 31 P) spectroscopies.

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Section: Dithiophosphatementioning

confidence: 99%

New Homodinuclear Alkyl and Aryl Dithiophosphonato Cd(II) and Hg(II) complexes: Syntheses and Characterizations

Sağlam¹,

Bulat

Acar

et al. 2020

Journal of the Turkish Chemical Society Section A: Chemistry

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“…Phosphorus-1,1-dithiolates obtained from a PTPA and a nucleophile are soft base-type, bidentate ligands, and they find some use in industry (12,13), agriculture (14), biochemistry (15), and metallurgy (16). The metal-complexing ability of phosphorus-1,1-dithiolates are based on sulfur donor groups that form four-membered chelate rings with metal cations (17).…”

Section: Introductionmentioning

confidence: 99%

The Syntheses and Characterization of New Dithiophosphonates derived from Novel 2,4-Bis(methoxytolyl)-1,3-dithia-2,4-diphosphetane 2,4- disulfides and Their Ni(II) Complexes

Sağlam¹,

Bulat²,

Yılmaz³

2020

Journal of the Turkish Chemical Society Section A: Chemistry

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Two novel perthiophosphonic acid anhydrides, 2,4-bis(R x,y)-1,3-dithia-2,4-diphosphetane 2,4disulfide [(R x,y-P(S)S)2; R x =3-methoxytolyl (SAV-B1) and R y =2-methoxytolyl (SAV-B2)] were synthesized. From the reaction of SAV-B1 and SAV-B2 with alcohols, four new dithiophosphonic acids [HS2P(R x,y)(ORn)] (Rn; R1=ethyl R2=2-propyl) were prepared. These acids were converted to corresponding ammonium salts, [NH4][S2P(R x,y)(ORn)]. The ammonium salts were further reacted with NiCl2.6H2O to prepare four new dithiophosphonato nickel(II) complexes, [Ni(S2P(R x,y)(ORn))2]. The ligands and complexes were characterized by elemental analyses, IR, ESI-MS, 1D 1 H, 13 C, 31 P NMR and 2D HSQC techniques. Complementary structural information was provided by the HSQC spectrum of the [NH4][S2P(R x,y)(OR2)]. The structure of the perthiophosphonic acid anhydrides was deduced from the structures of dithiophosphonates thereof.

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New Heterobimetallic Ferrocenyl Dithiophosphonato Cd(II) and Hg(II) Complexes: DNA Interactions, Antimicrobial and Anticancer Activity Studies of the Cd(II) Complexes

et al. 2021

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A series of new ferrocenyldithiophosphonato complexes of Cd(II) and Hg(II) ions were synthesized and characterized by spectroscopic methods. The antiproliferative activities of the ligands and their Cd(II) complexes were screened against four human cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. While the ligands were inactive in the three cancer cell lines screened, their Cd(II) complexes showed a very toxic effect against all cell lines. The complexes especially demonstrated the highest efficacy in the breast cancer cell line among the others. They were found to have higher cytotoxic activity compared to positive controls used in all cell lines. Furthermore, the ligands and their Cd(II) complexes were tested for antimicrobial activity against some pathogen bacteria and yeast strains. The minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), values were found to be in the ranges of 39.06-612 μM and 39.06-1250 μM, respectively. Besides, interactions between the compounds and plasmid DNA were studied by agarose gel electrophoresis. All of these cleaved double-strand supercoiled plasmid DNA at the highest concentration indicating DNA cleavage activity. The restriction enzyme digestion of the compound-DNA mixtures showed that compounds bind to A/A and G/G nucleotides.

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Crystal structure, antibacterial activity and nanoparticles of Cd(II) complex derived from dithiophosphonate ligand

Cited by 7 publications

References 38 publications

New Homodinuclear Alkyl and Aryl Dithiophosphonato Cd(II) and Hg(II) complexes: Syntheses and Characterizations

New Homodinuclear Alkyl and Aryl Dithiophosphonato Cd(II) and Hg(II) complexes: Syntheses and Characterizations

The Syntheses and Characterization of New Dithiophosphonates derived from Novel 2,4-Bis(methoxytolyl)-1,3-dithia-2,4-diphosphetane 2,4- disulfides and Their Ni(II) Complexes

New Heterobimetallic Ferrocenyl Dithiophosphonato Cd(II) and Hg(II) Complexes: DNA Interactions, Antimicrobial and Anticancer Activity Studies of the Cd(II) Complexes

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