Crystal structure, in vitro cytotoxicity, DNA binding and DFT calculations of new copper (II) complexes with coumarin-amide ligand

Lu, Weiying; Tang, Jiongya; Gu, Zhenzhen; Sun, Lu; Wei, Haimeng; Wang, Yanqin; Yang, Shilong; Chi, Xingwei; Xu, Li

doi:10.1016/j.jinorgbio.2022.112030

Cited by 12 publications

(7 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Copper based anticancer agents are so promising that some of them are in the preclinical and clinical trial phase. 12 It is worth emphasizing the key work of L. Ruiz-Azuara and co-workers that had reported a Cu( ii ) compound: [Cu( ii )(4,4′-dimethyl-2,2′-bipyridine)(acetylacetone)(NO 3 )(H 2 O)]. This work is in clinical trials (Phase I) in Mexico.…”

Section: Introductionmentioning

confidence: 93%

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties

Mandal,

Nandi,

Benmansour

et al. 2024

New J. Chem.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 93%

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties

Mandal,

Nandi,

Benmansour

et al. 2024

New J. Chem.

View full text Add to dashboard Cite

show abstract

“…Lu et al synthesized coumarin-3-formyl-(3-aminomethylpyridine) in order to utilize it as a ligand to generate three different Cu(II) complexes - a binuclear Cu(II) acetate complex, a mononuclear Cu(II) nitrate complex, and a binuclear Cu(II) nitrate complex ( Lu et al, 2023 )–compounds 48–50 respectively. The ligand and the complexes were tested against HeLa, HepG2, MCF-7, and A549 human cancer cell lines and the normal HUVEC cell line using the MTT assay.…”

Section: Coumarin Complexes With Anticancer Activitymentioning

confidence: 99%

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Todorov,

Kostova

2024

Front. Chem.

View full text Add to dashboard Cite

Coumarin (2H-1-benzopyran-2-one) presents the fundamental structure of an enormous class of biologically active compounds of natural, semi-synthetic, and synthetic origin. Extensive efforts are continually being put into the research and development of coumarin derivatives with medicinal properties by the broad scientific community. Transition metal coordination compounds with potential biological activity are a “hot topic” in the modern search for novel drugs. Complexation with transition metals can enhance the physiological effect of a molecule, modify its safety profile, and even imbue it with novel attributes of interest in the fields of medicine and pharmacy. The present review aims to inform the reader of the latest developments in the search for coumarin transition metal complexes with biological activity, their potential applications, and structure-activity relationships, where such can be elucidated. Each section of the present review addresses a certain kind of biological activity (antiproliferative, antioxidant, antimicrobial, etc.), explores the most recent discoveries in the field, and, at the same time, tries to offer useful perspectives for potential future investigations.

show abstract

“…These compounds have anti-inflammatory, antioxidant, and antitumor activities [366]. A coumarin-Cu complex [367,368] and a coumarin-Cu-thiosemicarbazone hybrid have been effective antiproliferative agents in cell lines of different types of cancer [369], and a coumarin-amide-Cu complex was shown to have greater antitumor capacity than CDDP in a breast cancer cell line [370]. Two studies in OC cells have demonstrated the antitumor effect of two natural derivatives of coumarin, 4-methylumbelliferone, and Osthole.…”

Section: Coumarinsmentioning

confidence: 99%

Copper in Gynecological Diseases

Conforti,

Delsouc,

Zorychta

et al. 2023

IJMS

View full text Add to dashboard Cite

Copper (Cu) is an essential micronutrient for the correct development of eukaryotic organisms. This metal plays a key role in many cellular and physiological activities, including enzymatic activity, oxygen transport, and cell signaling. Although the redox activity of Cu is crucial for enzymatic reactions, this property also makes it potentially toxic when found at high levels. Due to this dual action of Cu, highly regulated mechanisms are necessary to prevent both the deficiency and the accumulation of this metal since its dyshomeostasis may favor the development of multiple diseases, such as Menkes’ and Wilson’s diseases, neurodegenerative diseases, diabetes mellitus, and cancer. As the relationship between Cu and cancer has been the most studied, we analyze how this metal can affect three fundamental processes for tumor progression: cell proliferation, angiogenesis, and metastasis. Gynecological diseases are characterized by high prevalence, morbidity, and mortality, depending on the case, and mainly include benign and malignant tumors. The cellular processes that promote their progression are affected by Cu, and the mechanisms that occur may be similar. We analyze the crosstalk between Cu deregulation and gynecological diseases, focusing on therapeutic strategies derived from this metal.

show abstract

Crystal structure, in vitro cytotoxicity, DNA binding and DFT calculations of new copper (II) complexes with coumarin-amide ligand

Cited by 12 publications

References 72 publications

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Copper in Gynecological Diseases

Contact Info

Product

Resources

About

Crystal structure, in vitro cytotoxicity, DNA binding and DFT calculations of new copper (II) complexes with coumarin-amide ligand

Cited by 12 publications

References 72 publications

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu3OH core with regard to aspects of antiproliferative activity and magnetic properties

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu3OH core with regard to aspects of antiproliferative activity and magnetic properties

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Copper in Gynecological Diseases

Contact Info

Product

Resources

About

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties