Crystal Structure, Magnetic Study, and Antidiabetic Activity of Ni(II) Complex with N,O‐Donors Ligands

Abstract

Coordination chemistry of divalent ions involving multidentate ligands have received limited attention. The present work reports the synthesis of a mixed ligand complex of Ni(II) which is characterized by X-ray single-crystal diffraction, thermal, IR spectroscopy, magnetic, and in vitro antidiabetic activity. The atomic arrangement of the complex consists of two Ni(II) bridged by two ligands of organic molecules 5-(pyridin-2-yl)-1,2,4-triazol-1-ide (Ligand L1) and 2-(4-chlorobenzoyl)benzoate (Ligand L2) which throw their nitrogen and oxygen atoms. The Ni 2+ adopts a distorted octahedral geometry (NiO 2 N 2 (OH 2 ) 2 ). Infrared spectroscopy shows the existence of O─H, C─N, C═O, and absorption bands Ni─ (O,N). The thermal study proves that this compound undergoes dehydration then decomposition over a large domain of temperature. The magnetic properties of the complex demonstrate an antiferromagnetic interaction between two adjacent nickel atoms mediated by throw ligand (L1). The antidiabetic effect of this compound is supported by a biological test in vitro and is confirmed by molecular docking suggesting good inhibitory activity of the prepared complex for 𝜶-amylase.