Crystal structure of two new polymeric copper(II) complexes active against Trypanosoma cruzi

Paixão, Drielly A.; Oliveira, Letícia Parreira; Maia, Pedro Ivo da Silva; Deflon, Victor M.; Carneiro, Zumira Aparecida; Almeida, Katia Júlia de; Lopes, Norberto P.; Pivatto, Marcos; Chaves, Joana Darc S.; Albuquerque, Sérgio de; Almeida, Mauro Vieira de; Guilardi, Silvana; Guerra, Wendell

doi:10.1016/j.jscs.2018.01.002

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…Thus, these compounds are candidates for preclinical studies. The study is in agreement with a similar study which showed that organic compounds exhibit enhanced activity upon coordination with metal ions [7,8].…”

Section: Liver Function Indicessupporting

confidence: 93%

“…Research has established significant progress in the exploitation of transition metal complexes as drugs and the efficacy of some therapeutic agents has been reported to have increased upon coordination to transition metal [6][7][8][9]. The development of more potent metalbased drugs has been under investigation over decades, and it has been discovered that inorganic compounds have an enormous impact on medicine [10].…”

Section: Introductionmentioning

confidence: 99%

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Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats

Osunniran¹,

Obaleye²,

Tella³

et al. 2021

Bull. Chem. Soc. Eth.

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Transition metal complexes of Cu(II), Co(II) and Ni(II) with eflornithine hydrochloride hydrate (EFN), an antitrypanosomiasis drug, as ligand have been synthesized and characterized by melting point, elemental analysis, Fourier transform infrared (FTIR), electronic spectra, magnetic susceptibility and electrospray ionization mass spectrometry (ESI-MS). The FTIR spectral data suggested the coordination modes of the ligand to be bidentate, coordinated to the metal ions through its carboxylate oxygen atom and an amino nitrogen atom. From the microanalytical data, the stoichiometry of the metal complexes is 1:2 (metal to ligand). The electronic absorption and magnetic susceptibility studies generally suggested octahedral geometry for the metal complexes. Toxicological evaluation of the ligand (EFN) and complexes were carried out using albino rats. Twenty-five albino rats that were used for the experiment were randomly divided into five groups and animals in group 1 served as a control. All the animals were sacrificed twenty-four hours after completion of their doses. The results revealed a high level of toxicity of EFN than the synthesized metal complexes. KEY WORDS: Eflornithine hydrochloride hydrate, Carboxylate moiety, Antitrypanosomiasis drug, Toxicological evaluation, Albino rats Bull. Chem. Soc. Ethiop. 2020, 34(3), 489-500. DOI: https://dx.doi.org/10.4314/bcse.v34i3.6

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Section: Liver Function Indicessupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats

Osunniran¹,

Obaleye²,

Tella³

et al. 2021

Bull. Chem. Soc. Eth.

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“…In the course of complexation, we note a hypsochromic effect of the band at 280 nm of the thiosemicarbazide group and bathochromic effect of the band at 380 nm of the naphthalene ring. The appearance of two bands, one at 400 nm and the other at 620 nm is attributed to d-d transition which can suggests two geometries: square plane and square pyramidal respectively (Scheme 1a) [41]. In the case of in situ cobalt complexes (Co/L1: 2/1), hypsochromic and bathochromic effects are not appearance (Figure 5b).…”

Section: Uv-visible Studies Of the In Situ Complexesmentioning

confidence: 97%

New thiosemicarbazone Schiff base ligands: Synthesis, characterization, catecholase study and hemolytic activity

Nehar

Mahboub

Louhibi

et al. 2020

Journal of Molecular Structure

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Two novel thiosemicarbazones ligands have been synthesized and characterized by FT-IR, ESI-MS, 1 H NMR, and also by single-crystal X-ray diffraction for L1. The crystal structure shows that L1 molecules are planar and are connected via N-H-S and O-H-S interactions. The catecholase activity of is situ copper and cobalt complexes of this ligands has been investigated against 3,5-di-tert-butylcatechol. The progress of the oxidation reactions was closely monitored over time following the strong peak of 3,5-DTBC using UV-Vis. Oxidation rates were determined from the initial slope of absorbance vs. time plots, then analyzed by Michaelis-Menten equations. Catechol oxidation reactions were realized using different concentrations of copper and cobalt acetate and ligands (L/Cu: 1/1, 1/2, 2/1). The results show that all complexes were able to catalyze the oxidation of 3,5-DTBC. Acetate complexes have the highest activity. CuL1 and CoL1 complexes act as a catalyst and inhibitor. While copper and cobalt complexes obtained from ligand L2 illustrate concentration-independent oxidation activation. The hemolysis study performed by L1 increases as a function of its concentration. However, ligand L2 has no hemolytic effect.

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“…The primary concern is that the two drugs available to treat this illness, nifurtimox and benznidazole, exhibit severe side effects such as neuropathy, anorexia, and weight loss, among others. Add to this the fact that there is no effective treatment for the chronic form of the disease, whose symptoms include mega disease of the esophagus or colon, and cardiomyopathy, the latter being the most common cause of death [111,112]. Furthermore, there is concern that strains resistant to these drugs have already been reported [113].…”

Section: Antiparasitic Activitymentioning

confidence: 99%

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Rosário,

Moreira,

Rosa

et al. 2023

Molecules

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Bismuth-based drugs have been used primarily to treat ulcers caused by Helicobacter pylori and other gastrointestinal ailments. Combined with antibiotics, these drugs also possess synergistic activity, making them ideal for multiple therapy regimens and overcoming bacterial resistance. Compounds based on bismuth have a low cost, are safe for human use, and some of them are also effective against tumoral cells, leishmaniasis, fungi, and viruses. However, these compounds have limited bioavailability in physiological environments. As a result, there is a growing interest in developing new bismuth compounds and approaches to overcome this challenge. Considering the beneficial properties of bismuth and the importance of discovering new drugs, this review focused on the last decade’s updates involving bismuth compounds, especially those with potent activity and low toxicity, desirable characteristics for developing new drugs. In addition, bismuth-based compounds with dual activity were also highlighted, as well as their modes of action and structure–activity relationship, among other relevant discoveries. In this way, we hope this review provides a fertile ground for rationalizing new bismuth-based drugs.

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Crystal structure of two new polymeric copper(II) complexes active against Trypanosoma cruzi

Cited by 9 publications

References 31 publications

Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats

Toxicological assessment of synthesized and characterized transition metal(II) complexes of eflornithine hydrochloride hydrate on albino rats

New thiosemicarbazone Schiff base ligands: Synthesis, characterization, catecholase study and hemolytic activity

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

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