Crystal structure, spectroscopic studies, DFT calculations, cyclic voltammetry and biological activity of a copper (II) Schiff base complex

BENABID, Wafa; Ouari, Kamel; Bendia, Sabrina; Bourzami, Riadh; Ali, Mustapha Ait

doi:10.1016/j.molstruc.2019.127313

Cited by 47 publications

(5 citation statements)

References 58 publications

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“…As seen in Tables 4, 5 and Figure 3, overall, the synthesized compounds were found to have a higher anti-proliferative effect in ECT than the standard chemotherapy. The use of compounds in combination with EP significantly decreased the IC 50 compared to the use of compounds alone (p < 0.05) (Figure 3).…”

Section: Efficacy Of Electroporation (Ep) In the Treatmentmentioning

confidence: 83%

“…[1 -4] Schiff bases and their metal complexes are commonly employed in a variety of applications, including anticancer, anti-HIV (human immunodeficiency virus), antiradical, antibacterial, antifungal, antineoplastic activities, bio-modeling techniques, and DNA cleavage. [5][6][7] Glioblastoma is the most commonly seen primary brain cancer with the highest severity. It has a median survival of about 14-15 months.…”

Section: Introductionmentioning

confidence: 99%

“…Schiff bases are considered promising precursors for the synthesis of new bioactive compounds of medicinal relevance due to their biological and pharmacological importance and ability to form chelates with various transition metals [1–4] . Schiff bases and their metal complexes are commonly employed in a variety of applications, including anticancer, anti‐HIV (human immunodeficiency virus), antiradical, antibacterial, antifungal, antineoplastic activities, bio‐modeling techniques, and DNA cleavage [5–7] …”

Section: Introductionmentioning

confidence: 99%

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Electroporation Enhances the Anticancer Effects of Novel Cu(II) and Fe(II) Complexes in Chemotherapy‐Resistant Glioblastoma Cancer Cells

Alkış

Buldurun

Alan

et al. 2023

Chemistry & Biodiversity

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Schiff base ligand (L) was obtained by condensation reaction between 4-aminopyrimidin-2(1H)-one (cytosine) with 2-hydroxybenzaldehyde. The synthesized Schiff base was used for complexation with Cu(II) and Fe(II) ions used by a molar (2 : 1 mmol ration) in methanol solvent. The structural features of ligand, Cu(II), and Fe(II) metal complexes were determined by standard spectroscopic methods (FT-IR, elemental analysis, proton and carbon NMR spectra, UV/VIS, and mass spectroscopy, magnetic susceptibility, thermal analysis, and powder X-ray diffraction). The synthesized compounds (Schiff base and its metal complexes) were screened in terms of their anti-proliferative activities in U118 and T98G human glioblastoma cell lines alone or in combination with electroporation (EP). Moreover, the human HDF (human dermal fibroblast) cell lines was used to check the biocompatibility of the compounds. Anti-proliferative activities of all compounds were ascertained using an MTT assay. The complexes exhibited a good anti-proliferative effect on U118 and T98G glioblastoma cell lines. In addition, these compounds had a negligible cytotoxic effect on the fibroblast HDF cell lines. The use of compounds in combination with EP significantly decreased the IC 50 values compared to the use of compounds alone (p < 0.05). These results show that newly synthesized Cu(II) and Fe(II) complexes can be developed for use in the treatment of chemotherapy-resistant U118 and T98G glioblastoma cells and that treatment with lower doses can be provided when used in combination with EP.

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Section: Efficacy Of Electroporation (Ep) In the Treatmentmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electroporation Enhances the Anticancer Effects of Novel Cu(II) and Fe(II) Complexes in Chemotherapy‐Resistant Glioblastoma Cancer Cells

Alkış

Buldurun

Alan

et al. 2023

Chemistry & Biodiversity

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“…49,50 Regarding the metal complexes of BTMDs, most displayed new peaks with lower absorbance in their UV-vis spectra at wavelengths greater than 360 nm. These peaks can be associated with ligand-to-metal charge transfer (LMCT) transitions 51,52 and d-d transition. 53,54 Almost all the metal complexes displayed shifts in their UV-vis spectra upon complexation, with some peaks showing a redshift (bathochromic shift) and others a blueshift (hypsochromic shift).…”

Section: View Article Onlinementioning

confidence: 99%

Synthesis and characterization of N,N′-bis(2-thienylmethylene)-1,X-diaminobenzene isomers (X = 2, 3, 4) and their metal complexes

Vahdatiyekta,

Zniber,

Nikiforow

et al. 2024

Mater. Adv.

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“…HOMO is the highest energy filled molecular orbital and LUMO is the lowest energy vacant molecular orbital. HOMO represents the desire to donate an electron while LUMO represents the desire to gain an electron (Fleming, 2010;Benabid et al, 2020). HOMO and LUMO have been carefully evaluated to understand the ligand reaction and to specify the reactive sites.…”

Section: Figure 4 Percentage Of Inhibition Of 5-clpah and Streptomyci...mentioning

confidence: 99%

Design, DFT Calculations and Antimicrobial Activity of New Synthesized Piperazine Derivative

MUHAMMET>

2023

Gazi University Journal of Science Part A: Engineering and Innovation

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The title compound (2,2'-(piperazine-1,4-diyl)bis(N'-((E)-5-chloro-2-hydroxybenzylidene) acetohydrazide) (5-ClPAH) was synthesized by reacting 1,4-Piperazinediacetic acid, 1,4-dihydrazide and 5 -Chloro-2-hydroxybenzaldehyde. Mass spectrometry, 1H, 13C-NMR, IR results of the synthesized compound were examined. Many information about physical and chemical properties of 5-ClPAH can be obtained by theoretical calculations. Density functional theory (DFT) is widely used theoretical method for predicting of chemical structures. The structure was optimized using DFT/6311G method with GAUSSIAN09. Frontier Molecular Orbitls (HOMO and LUMO) energies were calculated. Global reactivity descriptors and also electrophilic and nucleophilic regions were defined by molecular electrostatic potential surface. Antibacterial and fungal activity were evaluated.

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Crystal structure, spectroscopic studies, DFT calculations, cyclic voltammetry and biological activity of a copper (II) Schiff base complex

Cited by 47 publications

References 58 publications

Electroporation Enhances the Anticancer Effects of Novel Cu(II) and Fe(II) Complexes in Chemotherapy‐Resistant Glioblastoma Cancer Cells

Electroporation Enhances the Anticancer Effects of Novel Cu(II) and Fe(II) Complexes in Chemotherapy‐Resistant Glioblastoma Cancer Cells

Synthesis and characterization of N,N′-bis(2-thienylmethylene)-1,X-diaminobenzene isomers (X = 2, 3, 4) and their metal complexes

Design, DFT Calculations and Antimicrobial Activity of New Synthesized Piperazine Derivative

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