Crystal structures, electrochemical properties, antioxidant screening and <i>in vitro</i> cytotoxic studies on four novel Cu(II) complexes of bidentate Schiff base ligands derived from 2-methoxyethylamine

Abbasi, Zeinab; Salehi, Mehdi; Kubicki, Maciej; Khaleghian, Ali

doi:10.1080/00958972.2017.1323082

Cited by 27 publications

(14 citation statements)

References 58 publications

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“…In all complexes and metal nano oxides, the viability of the cancer cells decreased in a dose‐dependent manner. A comparison of Cu(II) complexes with HL 1 ligand with cobalt(III) and V(IV) complexes reported here shows that metal center has a high effect on anticancer activity . It is important to mention that the copper(II) complex presented herein showed a better growth inhibitory effect than the previously reported copper complexes …”

Section: Resultssupporting

confidence: 46%

“…The complexes were synthesized in good yields by reaction between the ligands (HL 1–2 ) and metal salts in methanol following a similar procedure as described elsewhere for the parent complex, Cu(L 2 ) 2. In a typical experiment, a solution of Schiff base ligand (3 mmol, 0.54 g HL 1 and 0.63 g HL 2 ) in 20 mL of methanol was placed in a round bottom flask equipped with a magnetic stirrer and a reflux condenser. This solution was heated to about 70 °C while being stirred and then a solution of appropriate metal salt (1 mmol Co(OAc) 2 .4H 2 O (0.25 g) and 1.5 mmol for VO(acac) 2 (0.39 g) and Cu(OAc) 2 .H 2 O (0.29 g) salt) in MeOH (20 mL) was added drop‐wise.…”

Section: Methodsmentioning

confidence: 99%

“…This study was conducted to investigate the cytotoxicity and ability of nanoparticles to damage cancer cells. Recently, we have reported the synthesis, characterization and in vitro anticancer properties of NO Schiff base complexes . In the present study, we made an effort to design and synthesize new Schiff base complexes to screen the cytotoxic activities using MTT assay.…”

Section: Introductionmentioning

confidence: 99%

“…Herein, we report the synthesis, characterization and crystal structure determination of new Co(III), V(IV) and Cu(II) Schiff base complexes (Scheme ). Schiff base ligands (HL 1 and HL 2 ) and Cu(II) complex ( 3 ) were synthesized and identified as described before . The complexes were then used as a solid precursor to produce pure‐phase nanoparticles by solid‐state thermal decomposition.…”

Section: Introductionmentioning

confidence: 99%

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Co(III), V(IV) and Cu(II) complexes of bidentate N,O‐donor Schiff base ligands: Characterization, anticancer activities and metal oxide nanoparticles preparation via solid state thermal decomposition

Abbasi

Salehi

Khaleghian

et al. 2018

Applied Organom Chemis

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Three new mononuclear Schiff base complexes [Co(L1)3 (1), VO(L1)2 (2) and Cu(L2)2 (3)] were synthesized, characterized and used as a precursor for preparation of metal oxide nanoparticles. The crystal structure of compounds was determined using single crystal X‐ray diffraction. The Co(III) coordination sphere consists of three phenolato oxygens and three imino nitrogen atoms from three Schiff base ligands, thus forming a distorted octahedral geometry. In complex (2), the vanadium(IV) is five‐coordinated in a regular tetragonal pyramid fashion and the Cu(II) ion is four coordinated with a square‐planar geometry in the complex (3). The nanoparticles were characterized by Fourier transform infrared spectroscopy (FT‐IR), X‐ray powder diffraction (XRD) and field emission scanning electron microscopy (FE‐SEM). In vitro cell proliferation via MTT assay was studied to calculate the cytotoxicity of complexes and metal oxide nanoparticles against gastric cancer cell line (MKN‐45). The results showed that all compounds have anticancer activity with dose–response dependency.

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Section: Resultssupporting

confidence: 46%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Co(III), V(IV) and Cu(II) complexes of bidentate N,O‐donor Schiff base ligands: Characterization, anticancer activities and metal oxide nanoparticles preparation via solid state thermal decomposition

Abbasi

Salehi

Khaleghian

et al. 2018

Applied Organom Chemis

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“…Vanadium complexes have been reported to have interesting antibacterial activities [17][18][19][20]. It has been reported that V(IV) complexes high effect on anticancer activity [21].…”

Section: Introductionmentioning

confidence: 99%

Stability of Vanadium Chalcone Complexes

Borge¹,

Patil²

2020

Stability and Applications of Coordination Compounds

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The vanadyl(IV) complexes of substituted chalcones were prepared by refluxing vanadyl sulphate with different substituted chalcones in ethanoic medium. The chalcones were prepared with different aromatic aldehydes like benzaldehyde, hydroxy benzaldehyde, nitro benzaldehyde and chloro benzaldehyde. The synthesized Vanadium complexes were characterized by different spectral techniques. The IR spectral studies revealed that the chalcone derivatives are bidentate ligand. Magnetic studies, electron spin resonance and UV studies suggest that the complexes are in square pyramidal geometry. Conductance measurements suggest that all complexes are non-electrolyte in DMF. The thermal study explained the stability of complex and its decomposition. The synthesized ligand and metal complexes were screened for their antibacterial activity against E. coli and Staphylococcus aureus bacterial strains and for antifungal activity against P. notatum.

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Synthesis, characterization, spectral studies two new transition metal complexes derived from pyrazolone by theoretical studies, and investigate anti‐proliferative activity

Parvarinezhad

Salehi

Malekshah

et al. 2022

Applied Organom Chemis

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Metal (II) complexes of Cu (II) (1), and Ni (II) (2) with Schiff base derived from 4‐amino‐antipyrine were synthesized. These complexes were fully characterized by FTIR, and UV–Vis spectroscopies, crystallography, and cyclic voltammetry. Crystal structures of these two complexes were mononuclear. Furthermore, complex Cu (II) (1), of [CuII(H2L1)(NO3)] composition, is 4‐coordinated in a square‐planar environment. Complex Ni (II) (2) is six‐coordinated in an octahedral geometry and can be described as [NiII (H2L2)2]; this crystal structure additionally contains solvent—DMSO molecule. The experimental structural models are interpreted by Hirshfeld surface analysis, density functional theory calculations, Molecular Electrostatic Potential, and the atoms in molecules method. Density functional theory calculations support all experimental results, as well as predict the correct structure of complexes. In addition, the types of interactions in the structure of the complexes were identified by Hirshfeld surface analysis, and molecular electrostatic potential was used to confirm the formation of these interactions, and the results of these studies are consistent. Then the theory of atom in molecule was performed, which predicts the type of interaction of the ligand metal non‐covalently with ionic nature. To determine the mechanism of adsorption of complexes on chitosan, a Monte Carlo adsorption locator was utilized. The adsorption process of complex [CuII (H2L1)NO3]and [NiII(H2L2)2(C2H6SO)] in the aqueous phase on CS was calculated by Monte Carlo adsorption locator. The results showed complex [NiII(H2L2)2(C2H6SO)] had a high binding efficiency on CS compared with complex [CuII (H2L1)NO3]. Moreover, the anticancer effects of ligands and complexes toward MTT assay against SW480 cancer cell lines were investigated. The biological activity results illustrate that the ligands and complexes have anticancer activity. Molecular docking studies were also carried out for both complexes to find their binding affinity with protein B‐cell lymphorna (BCL‐2, PDB ID: 4LXD).

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Crystal structures, electrochemical properties, antioxidant screening and in vitro cytotoxic studies on four novel Cu(II) complexes of bidentate Schiff base ligands derived from 2-methoxyethylamine

Cited by 27 publications

References 58 publications

Co(III), V(IV) and Cu(II) complexes of bidentate N,O‐donor Schiff base ligands: Characterization, anticancer activities and metal oxide nanoparticles preparation via solid state thermal decomposition

Co(III), V(IV) and Cu(II) complexes of bidentate N,O‐donor Schiff base ligands: Characterization, anticancer activities and metal oxide nanoparticles preparation via solid state thermal decomposition

Stability of Vanadium Chalcone Complexes

Synthesis, characterization, spectral studies two new transition metal complexes derived from pyrazolone by theoretical studies, and investigate anti‐proliferative activity

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