Crystal Structures, Interactions with Biomacromolecules and Anticancer Activities of Mn(II), Ni(II), Cu(II) Complexes of Demethylcantharate and 2-Aminopyridine

Abstract

Three novel transition metal complexes (Hapy)(2)[M(DCA)(2)]·6H(2)O (M = Mn(II) (1), Ni(II) (2), Cu(II) (3); DCA = demethylcantharate, 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate, C(8)H(8)O(5); Hapy = 2-aminopyridine acid, C(5)H(7)N(2)) were synthesized and characterized by elemental analysis, infrared spectra, thermogravimetric analysis and X-ray diffraction. DNA binding properties of the complexes were investigated by electronic absorption spectra, fluorescence spectra and viscosity measurements. Results indicated the complexes could bind to DNA through partial intercalation mode with binding constants K ( b )/(L·mol(-1)) of 1.91 × 10(4) (1), 5.13 × 10(4) (2) and 1.12 × 10(5) (3) at 298 K. Meanwhile, the interactions of the complexes with BSA were also studied by fluorescence spectra. The results suggested that the complexes could quench the fluorescence of BSA through static quenching with the binding constants K ( A )/(L·mol(-1)) of 1.44 × 10(6) (1), 1.14 × 10(7) (2) and 2.98 × 10(4) (3). And the main contribution was tryptophan residues of BSA. The antiproliferative activity test revealed that complexes showed more intense inhibition ratios against human hepatoma cells lines and human gastric cancer cells lines in vitro. Copper(II) complex (3) possesses the strongest inhibition ratio against human hepatoma cells.

Copper(II), nickel(II), and ruthenium(III) complexes of an oxopyrrolidine-based heterocyclic ligand as anticancer agents

“…urease, Oxopyrrolidine heterocyclic ligand 2111 carbon monoxide dehydrogenase and hydrogenase [18]. Many articles have reported DNA binding and anticancer potentials of nickel complexes owing to good affinity of Ni(II) for DNA and some DNA binding proteins [19][20][21][22][23]. Ruthenium complexes have been known for their anticancer potential [24][25][26].…”

Characterisation of a unique manganese-containing biosurfactant produced from Pseudomonas aeruginosa strain S16, isolated from soil found in a mixed farm, located in Ibadan, Oyo State, Nigeria

“…The activities of certain man-made Manganese (III) compounds against the reactive peroxynitrite ion, have also been documented in the research by Carballal et al (2018). In addition, the anticancer properties of one of the Manganese (II) arti cially-made compounds by Zhang et al(2012) have been documented in their research. These studies bring to light the diverse, bioactivities of manganese-containing compounds.…”

A family of manganese complexes containing heterocyclic-based ligands with cytotoxic properties

“…scarcely studied for such purpose. [18][19][20][21][22][23][24] For metal-based drugs, the ligands may play important roles in target site recognition; the presence of a chelating ligand may control the reactivity toward different biomolecules (DNA, enzymes) and play a key role in the interaction with them through hydrogen bonding or intercalation. In addition, hydrophobicity may enhance cellular uptake.…”