Crystalline-like Patterns in the Nuclei of Cells infected with an Animal Virus

Kjellén, Lars; Lagermalm, Gösta; Svedmyr, Arne; Thorsson, K. G.

doi:10.1038/175505a0

Cited by 75 publications

(22 citation statements)

References 5 publications

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“…The size of the virus particle reported here agrees well with all previous findings (1)(2)(3)(4)(5) in which material has been examined without air drying and possible accompanying distortion, and the diameter of the inner body or nucleoid also shows good agreement. The apparent structural differentiation observed here in the nucleoid has not previously been described; although so far no information is available concerning the significance of this finding, it is tempting to regard it as a reflection of the presence of more than one component within this region of the viru~ FIc.…”

Section: Discussionsupporting

confidence: 90%

Observations on the Fine Structure of Type 5 Adenovirus

Epstein

1959

The Journal of Cell Biology

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Section: Discussionsupporting

confidence: 90%

Observations on the Fine Structure of Type 5 Adenovirus

Epstein

1959

The Journal of Cell Biology

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“…These findings confirm observations reported by other investigators (2)(3)(4)(5). In order to exclude the possibility that the crystals might have resulted from fixation or other processes involved in preparing the material for light and electron microscope studies, living cultures were examined under the phase and interference microscopes.…”

supporting

confidence: 89%

The Occurrence of Intranuclear Crystals in Living HeLa Cells Infected with Adenoviruses

Leuchtenberger

Boyer

1957

The Journal of Cell Biology

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“…of herpes simplex virus was found to crystallize (4) in a manner analogous to the adenoviruses (5)(6)(7)(8)(9). Moreover, the nuclear membranes of cells infected by this strain frequently showed remarkable proliferation.…”

Section: I~a~s 43 To 61mentioning

confidence: 98%

Electron Microscopic Observations on the Development of Herpes Simplex Virus

Morgan

Rose

Holden

et al. 1959

The Journal of Experimental Medicine

262

108

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Electron microscopic study of the H.R. strain of herpes simplex virus in cells of the chicken chorioallantoic membrane (1) suggested that the virus differentiates within the nucleus, where particles possessing a central core and a single limiting membrane are randomly dispersed. In this earlier work the finding that ruptured nuclei were associated with large numbers of intracytoplasmic particles possessing double membranes appeared to be consistent with the hypothesis that the virus acquired a second membrane in the cytoplasm after release from the nucleus. However, cells in tissue culture infected with the H F E M strain of herpes simplex virus and examined by Stoker, Smith, and Ross (2) and herpes B virus examined by Reissig and Melnick (3) subsequently revealed intranuclear particles with double as well as single membranes, thus raising the possibility that development could be completed in the nucleus.Recently, a strain (J.M.) of herpes simplex virus was found to crystallize (4) in a manner analogous to the adenoviruses (5-9). Moreover, the nuclear membranes of cells infected by this strain frequently showed remarkable proliferation. The purposes of this paper are to illustrate and describe the viral crystals as well as the morphology of the cellular response to infection, and to propose an hypothesis concerning the manner of development and the mechanisms whereby virus may gain egress from intact cells. Materials and MetkodsHeLa cells were cultured in a medium consisting of Earle's balanced salt solution which contained 0.5 per cent lactalbumin hydrolysate, 0.25 per cent glucose, 0.1 per cent yeast extract, 0.3 per cent tris(hydroxymethyl)-aminomethane and 20 per cent horse serum. Stable human amnionic cells were cultivated in Eagle's medium to which 20 per cent horse serum * These studies were

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Crystalline-like Patterns in the Nuclei of Cells infected with an Animal Virus

Cited by 75 publications

References 5 publications

Observations on the Fine Structure of Type 5 Adenovirus

Observations on the Fine Structure of Type 5 Adenovirus

The Occurrence of Intranuclear Crystals in Living HeLa Cells Infected with Adenoviruses

Electron Microscopic Observations on the Development of Herpes Simplex Virus

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