Crystallization behaviour and drug release from bacterial polyhydroxyalkanoates

Akhtar, Saghir; Pouton, Colin W.; Notarianni, L. J.

doi:10.1016/0032-3861(92)90570-m

Cited by 55 publications

(35 citation statements)

References 17 publications

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“…It is 16 important that although the melting temperature and the thermal degradation temperature 17 decreased in all PHA specimens, the interval between these two parameters remained almost 18 the same. A decrease in the melting temperature (to 53-54°C) was also observed for PHA 19 tetrapolymers with another composition, which contained medium-chain-length monomers 20 with even numbers of carbon atoms (C 6 , C 8 , C 10 , C 12 , C 14 ) [7]. Thus, the PHA tetrapolymers 21…”

mentioning

confidence: 74%

Properties of a novel quaterpolymer P(3HB/4HB/3HV/3HHx)

Volova

Vinogradova

Zhila

et al. 2016

Polymer

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11Cupriavidus eutrophus В10646 was used to synthesize a series of polyhydroxyalkanoates 12 (PHA) tetrapolymers composed of the short-chain-length 3-hydroxybutyrate (3HB), 4-13 hydroxybutyrate (4HB), and 3-hydroxyvalerate (3HV) and the medium-chain-length 3-14 hydroxyhexanoate (3HHx). The molar fraction of 3HB in the copolymers varied between 63.5 15 and 93.1 mol.%, 3HV -between 1.1 and 24.6 mol.%, 4HB -between 2.4 and 15.6 mol.%, and 16 3HHx -between 0.4 and 4.8 mol.%. The properties of PHA tetrapolymers were significantly 17 different from those of the P(3HB) homopolymer: they had much lower degrees of crystallinity 18 (reaching 30-45%), and lower melting points and thermal decomposition temperatures, with the 19 interval between these temperatures remaining practically unchanged. Films prepared from PHA 20 tetrapolymers were rougher and more porous than P(3HB) films; they showed higher values of 21 elongation at break (up to 100-200%), i.e. were more elastic. Films prepared from PHA 22 tetrapolymers were biocompatible and had no toxic effect on mouse fibroblast NIH 3T3 cells. 23 24

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mentioning

confidence: 74%

Properties of a novel quaterpolymer P(3HB/4HB/3HV/3HHx)

Volova

Vinogradova

Zhila

et al. 2016

Polymer

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“…Широкий спектр лекарственных веществ используется в качестве активного начала вводимого в ПОБ его производные. Во-первых, это класс модельных соединений, используемых для изучения механизма контролируемого высвобождения таких как 2,7-дихлорфлуоресцеин [61], декстран-ФИТЦ [62], метиловый красный [63], 7-оксиэтилтеофиллин [64], кумарин [65]. Во-вторых, это лекарственные вещества, используемые в терапевтической практике: антибиотики и антибактериальные соединения (рифампицин [18,66], тетрациклин [67], цефоперазон и гентамицин [68], сульперазон и дуоцид [69], сульбактам [70], левофлоксацин, метронидазол [18]), противоопухолевые препараты (5-фторурацил [71], 2',3'-диацил-5-фтор-2'-деоксиуридин [30], паклитаксел, дексаметазон, хлорамбуцил, доксорубицин, этопозид [34,65]), противовоспалительные агенты (индометацин [72]), анальгетики (трамадол [73]), вазодилататоры и антитромбогенные препараты (дипиридамол [18,72,74]).…”

Section: поли-3-оксибутират и биополимерные системы на его основеunclassified

“…Помимо исследования кинетического профиля, для большинства из этих систем проведены испытания биосовместимости и фармакологической активности [18,30,34,66,69,70,73]. Отметим также, что в чистом виде (как гомополимер) ПОБ используется реже [30,63,64,66,72,73], чем когда в качестве биоразлагаемой матрицы (микросфер) используются полиоксиалканоаты, т.е. его гомологи.…”

Section: поли-3-оксибутират и биополимерные системы на его основеunclassified

“…Удержание и десорбция модельного соединения (метилового красного) из матрицы ПОБ, сформированной в результате кристаллизации из расплава, здесь зависели от кинетики кристаллизации и морфологии кристаллической фазы [63]. Удивительно, что общая величина степени кристаллизации не влияла на скорость высвобождения.…”

Section: рисунокunclassified

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Poly(3-hydroxybutyrate) and biopolymer systems on the basis of this polyester

et al. 2011

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Biodegradable biopolymers attract much attention in biology and medicine due to its wide application. The present review is designed to be a comprehensive source for research of biodegradable and biocompatible bacterial polymer, poly(3-hydroxybutyrate). This paper focuses on basic properties of biopolymer: biodegradability and biocompatibility, as well as on biopolymer systems: various materials, devices and compositions on the basis of biopolymer. Application of biopolymer systems based on poly(3-hydroxybutyrate) in medicine as surgical implants, in bioengineering as scaffold for cell cultures, and in pharmacy as drug dosage forms and drug systems is observed in the present review.

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“…11 The crystallization kinetics and morphology of P(HB-HV) polyesters both with and without the incorporation of a model drug, methyl red, had been investigated to influence drug release characteristics. 12 The release rate of the drug could be controlled over a wide range by proper choice of the kind and amount of additive in the preparation of the PHB microspheres.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of poly(3‐hydroxybutyrate) microspheres containing bovine serum albumin for controlled release

Zhao

Tian

Liu

et al. 2008

J of Applied Polymer Sci

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The utility of the Poly(3-hydroxybutyrate) (PHB) to encapsulate and control the release of bovine serum albumin (BSA), via microspheres, was investigated. Various preparing parameters, including polymer concentration in oil phase, emulsification concentration in external water phase, volume ratio of inner water phase to oil phase, and volume ratio of primary emulsion to external water phase were altered during the microspheres production. The effects of these changes on the morphological characteristics of the microspheres, size of the microspheres, drug loading, encapsulation efficiency, and drug release rates were examined. The diameter of the microspheres ranged from 6.9 to 20.3 lm and showed different degrees of porous structure depending on the different preparation parameters. The maximum and minimum BSA encapsulation efficiency within the polymeric microspheres were 69.8 and 7.5%, respectively, varying with preparation conditions. The controlled release characteristics of the microspheres for BSA were investigated in pH 7.4 media. The initial BSA burst release from 8.9 to 63.1% followed by constant slow release for 28 days was observed for BSA from BSA-loaded microspheres and followed the Higuchi matrix model. So, the release behavior of microspheres showed the feasibility of BSA-loaded microspheres as controlled release devices. Pristine BSA, pristine PHB microspheres, and BSA-loaded microspheres were analyzed by Fourier transform infrared spectrophotometer, which indicated no interaction between BSA and PHB. Differential scanning calorimetry on BSAloaded microspheres indicated a molecular level dispersion of BSA in the microspheres.

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Crystallization behaviour and drug release from bacterial polyhydroxyalkanoates

Cited by 55 publications

References 17 publications

Properties of a novel quaterpolymer P(3HB/4HB/3HV/3HHx)

Properties of a novel quaterpolymer P(3HB/4HB/3HV/3HHx)

Poly(3-hydroxybutyrate) and biopolymer systems on the basis of this polyester

Preparation and evaluation of poly(3‐hydroxybutyrate) microspheres containing bovine serum albumin for controlled release

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