Crystallization-driven assembly of fully degradable, natural product-based poly(l-lactide)-block-poly(α-d-glucose carbonate)s in aqueous solution

Song, Yue; Chen, Yingchao; Su, Lu; Li, Richen; Letteri, Rachel A.; Wooley, Karen L.

doi:10.1016/j.polymer.2017.06.065

Cited by 42 publications

(46 citation statements)

References 59 publications

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“…Recently, Wooley and co-workers showed the assembly of cylinders and bundled cylinders using CDSA approaches. 63 Cheng and co-workers also fabricated 2D alternating rings of block copolymer and homopolymer, initially using block copolymer seeds to initiate homopolymer growth and afford 2D PLLA materials. 64 , 65 We have previously shown that CDSA is possible for various PLLA-containing block copolymers with exclusively cylindrical morphologies obtained with varying block compositions.…”

Section: Introductionmentioning

confidence: 99%

Controlling the Size of Two-Dimensional Polymer Platelets for Water-in-Water Emulsifiers

et al. 2017

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A wide range of biorelevant applications, particularly in pharmaceutical formulations and the food and cosmetic industries, require the stabilization of two water-soluble blended components which would otherwise form incompatible biphasic mixtures. Such water-in-water emulsions can be achieved using Pickering stabilization, where two-dimensional (2D) nanomaterials are particularly effective due to their high surface area. However, control over the shape and size of the 2D nanomaterials is challenging, where it has not yet been possible to examine chemically identical nanostructures with the same thickness but different surface areas to probe the size-effect on emulsion stabilization ability. Hence, the rationale design and realization of the full potential of Pickering water-in-water emulsion stabilization have not yet been achieved. Herein, we report for the first time 2D poly(lactide) platelets with tunable sizes (with varying coronal chemistry) and of uniform shape using a crystallization-driven self-assembly methodology. We have used this series of nanostructures to explore the effect of 2D platelet size and chemistry on the stabilization of a water-in-water emulsion of a poly(ethylene glycol) (PEG)/dextran mixture. We have demonstrated that cationic, zwitterionic, and neutral large platelets (ca. 3.7 × 106 nm2) all attain smaller droplet sizes and more stable emulsions than their respective smaller platelets (ca. 1.2 × 105 nm2). This series of 2D platelets of controlled dimensions provides an excellent exemplar system for the investigation of the effect of just the surface area on the potential effectiveness in a particular application.

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Section: Introductionmentioning

confidence: 99%

Controlling the Size of Two-Dimensional Polymer Platelets for Water-in-Water Emulsifiers

et al. 2017

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“…(PEO), 20,21 polyacrylonitrile, 22 poly(ε-caprolactone), [23][24][25][26][27] polylactide, [28][29][30][31][32][33][34] polythiophene (PTH), [35][36][37] poly(hedral oligomeric silsesquioxane) (POSS) 38,39 and polyethylene (PE) [40][41][42][43][44][45][46][47] as the crystallizable core-forming block. The term "crystallization-driven self-assembly" (CDSA) has been used to describe cases in which crystallization of the core-forming block dominates the self-assembly process.…”

mentioning

confidence: 99%

Self-Seeding of Block Copolymers with a π-Conjugated Oligo(p-phenylenevinylene) Segment: A Versatile Route toward Monodisperse Fiber-like Nanostructures

et al. 2018

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Three well-defined crystalline-coil diblock copolymers of oligo(p-phenylene vinylene)-b-poly(N-isopropyl acrylamide) (OPV5-b-PNIPAM18, OPV5-b-PNIPAM49 and OPV5-b-PNIPAM75, the subscripts represent the number of repeat units of each block) with the same crystallizable core-forming OPV segment but different corona-forming PNIPAM blocks of various chain lengths were synthesized. Their solution self-assembly behavior was examined in methanol, ethanol and isopropanol. Both the solvent and the length of the PNIPAM block were found to affect the self-assembly of the block copolymers. In methanol, OPV5-b-PNIPAM18 formed a mixture of fiber-like micelles of uniform width and complex two-dimensional platelet-like structures with fiber-like micelles protruding from the ends. In ethanol and in isopropanol, this polymer only formed long fiber-like micelles of uniform width. OPV5-b-PNIPAM49 formed long fiber-like micelles (several micrometers) of uniform width in all three solvents, but under the same self-assembly conditions, OPV5-b-PNIPAM75 only formed short fiber-like micelles with lengths of several hundred nanometers. We examined systematically the temperature-induced self-seeding behavior of all three block copolymers, exploring the influence of PNIPAM chain length, solvent, annealing time and concentration of copolymer. The most remarkable result of these experiments is our finding that fiber-like micelles of uniform length, with controlled lengths up to 1 μm can be easily prepared from all three block copolymers, even from OPV5-b-PNIPAM75 that formed only much shorter micelles under self-nucleated self-assembly. We also showed that the self-seeding strategy can be extended to other OPV-containing diblock copolymer such as Commented [F1]: delete 3 OPV5-b-poly(2-(diethylamino)ethyl methacrylate) for preparing monodisperse fiber-like micelles of controllable length. These results show that the self-seeding approach to crystallization-driven self-assembly can be a versatile route to prepare uniform fiber-like micelles with controllable lengths for OPV-containing block copolymers.

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“…Other unique chemistries of interest include biopolymer conjugates and supramolecular pseudoblock copolymers (SPBCPs) . Biopolymer conjugates include traditional synthetic polymers with a biopolymer block or polypeptoids, which are comb‐like, glycine‐backbone polymers with substituents on the nitrogen of the glycine monomer . SPBCPs do not have a covalent bond between the two blocks.…”

Section: Unique Block Copolymers and Their Assembliesmentioning

confidence: 99%

“…As with most studies in this section, the crystalline block may be the nonunique block or the chemically unique, in this case, biopolymer, block. A study by Song et al . focused on PLLA‐ b ‐poly(α‐ d ‐glucose carbonate) (PDGC) copolymers where the PDGC block was subsequently functionalized with cysteine side groups (PLLA‐ b ‐PDGC‐cys).…”

Section: Unique Block Copolymers and Their Assembliesmentioning

confidence: 99%

Recent progress in block copolymer crystallization

Horn

Steffen

O'Connor

2018

Polymer Crystallization

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Block copolymers (BCPs) are important for technological advances in numerous industries, including but not limited to, electronics, biomedical, optics, environmental, and infrastructure. Because of their ubiquity, it is important to understand their hierarchical phase behavior to tune their macroscopic properties for efficient use. These macroscopic properties are derived from the microscopic self‐assembled structures. One unique form of hierarchical assembly exists when one or more of the polymeric blocks form lamellar crystals. These crystals are integral to understanding and predicting the macroscopic behavior. This review reports on recent advances in crystallization of BCPs, including bulk and solution assembly. Reports highlighting development in fundamental processes regarding crystallization mechanisms and behavior as well as for the design of practical applications are included.

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Crystallization-driven assembly of fully degradable, natural product-based poly(l-lactide)-block-poly(α-d-glucose carbonate)s in aqueous solution

Cited by 42 publications

References 59 publications

Controlling the Size of Two-Dimensional Polymer Platelets for Water-in-Water Emulsifiers

Controlling the Size of Two-Dimensional Polymer Platelets for Water-in-Water Emulsifiers

Self-Seeding of Block Copolymers with a π-Conjugated Oligo(p-phenylenevinylene) Segment: A Versatile Route toward Monodisperse Fiber-like Nanostructures

Recent progress in block copolymer crystallization

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